Global Respiratory Complications Therapeutics Market to 2022 - Innovative Pneumonia and Pulmonary Arterial Hypertension Therapies Dominate Varied Disease Market

  • ID: 4191093
  • Report
  • Region: Global
  • 197 Pages
  • GBI Research
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Respiratory Complications Market Forecast to Grow Moderately, from a Value of $21.8 Billion in 2015 to $30.2 Billion in 2022, at a CAGR of 4.7%

FEATURED COMPANIES

  • Actelion
  • Bayer
  • Bristol-Myers Squibb
  • GlaxoSmithKline
  • Medimmune
  • Pfizer
  • MORE

Respiratory complications are a diverse set of indications that include respiratory disorders, cardiovascular disorders and infectious diseases. They are therefore associated with a broad range of underlying pathophysiology, which is reflected in the range of therapies in development in the pipeline. Overall, there are 843 products in active development in the respiratory complications pipeline. However, this constitutes numerous individual indications, each of which is typically relatively small in terms of the number of pipeline products in development.

The most prominent individual indications in terms of respiratory complications therapeutics development are Pneumonia, Tuberculosis (TB), Respiratory Syncytial Virus (RSV) and Pulmonary Arterial Hypertension (PAH), which reflects the active nature of these indications in terms of overall product development.

In spite of a small late-stage pipeline, the respiratory complications market is forecast to grow moderately over the forecast period, from a value of $21.8 Billion in 2015 to $30.2 Billion in 2022, at a compound annual growth rate (CAGR) of 4.7%. This growth will be predominantly driven by already marketed products, rather than the approval of pipeline products, which are expected to have a limited impact on the market. Furthermore, generic impact on the market will be limited in terms of value, given the very low cost of generics typically used.

There are few drugs that generate substantial revenue in the current respiratory complications market, with only one generating over $1 Billion from revenues specific to these complications. This is the Prevnar family pneumococcal disease vaccine, which has been approved for a broad spectrum of patients, ranging from six-week-old infants to adults of 50 and over. In 2015 the vaccine family generated $6.3 Billion, and this level of revenue is expected to remain relatively stable over the forecast period.

Pfizer is expected to maintain its position as market leader throughout the entire forecast period. Although the company has a large number of drugs active in this area, spread across pneumonia and pulmonary embolism, it is predominantly the pneumonia vaccine Prevnar that drives its revenue derived from respiratory complications. Pfizer is expected to generate $7.3 Billion by 2022, rising from $6.9 Billion in 2015 at a CAGR of 0.8%. This marginal growth is attributed to the limited revenue growth of Prevnar, as well as some revenue growth for the anticoagulant Eliquis (apixaban), which is expected to generate $642.8m from respiratory complications by 2022.

The report "Global Respiratory Complications Therapeutics Market to 2022 - Innovative Pneumonia and Pulmonary Arterial Hypertension Therapies Dominate Varied Disease Market" provides an introduction to the respiratory complications therapeutics market, including disease epidemiology, symptoms, etiology, pathophysiology, co-morbidities and complications, diagnosis and prognosis.

In depth, it provides the following:

  • Provides an overview of the landscape for marketed products for respiratory complications, including product profiles of key marketed products and revenue projections for each of these drugs.
  • Analyzes the respiratory complication therapeutics pipeline, detailing, among other parameters, drug distribution by stage of development, molecule type and mechanism of action, plus an analysis of the key indications in the pipeline: pneumonia, TB, RSV and PAH.
  • Provides forecast projections to 2022 on a global level, with forecasts also provided for the US, plus aggregate revenue forecasts of the top five EU markets (the UK, France, Germany, Italy and Spain) and Japan.
  • Provides the company landscape in the respiratory complications therapeutics market, with an analysis of the key players, the types of company involved in this disease cluster, whether this disease cluster comprises a large proportion of each company’s pipeline portfolio, and total revenue.
  • Analyzes trends in co-development and licensing deals relating to respiratory complications therapeutics.

Scope

The respiratory complications market already contains commercially successful products.

  • Which classes of drug dominate the market?
  • What additional benefits have newly approved therapies brought to the market?

The respiratory complications pipeline is large, with significant diversity in terms of molecule types and targets.

  • Which molecular targets appear most frequently in the pipeline?
  • What are the commercial prospects for the most promising late-stage pipeline products?

The respiratory complications market is forecast to grow from $21.8 billion in 2015 to $30.2 billion in 2022, at a compound annual growth rate of 4.7%.

  • Which products are forecast to drive this substantial growth?
  • Will generic competition have a significant impact on the market over the forecast period?

The company landscape is becoming increasingly competitive.

  • What are the leading companies in terms of market share?
  • Which companies are forecast to experience the greatest growth in market share?
  • What are the drivers of growth for key companies in the market?
  • How dependent are the key companies on this disease cluster for revenue?

Reasons to buy

This report will allow you to:

  • Understand the current clinical and commercial landscape through a comprehensive study of disease epidemiology, pathogenesis, symptoms, diagnosis and prognosis for the key indications covered in the report, which include pneumonia, TB, RSV and PAH.
  • Assess the current treatment landscape, with product profiles covering prominent marketed therapies, including revenue forecasts.
  • Analyze the respiratory complications pipeline and stratify by stage of development, molecule type, and molecular target. The most promising late-stage therapies are profiled and assessed in terms of clinical performance and competitiveness, alongside a single-product forecast.
  • Predict growth in market size, with in-depth market forecasting from 2015 to 2022. The forecasts will provide an understanding of how epidemiology trends, new drug entries, and patent expirations will influence market value.
  • Identify the leading companies in the market, in terms of market share and growth. Company analysis determines how dependent the key companies in the market are on revenue derived from respiratory complications products. In addition, analysis determines the primary factors that will drive market growth for the key companies in the market.
  • Identify commercial opportunities in the respiratory complications deals landscape by analyzing trends in licensing and co-development deals.
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FEATURED COMPANIES

  • Actelion
  • Bayer
  • Bristol-Myers Squibb
  • GlaxoSmithKline
  • Medimmune
  • Pfizer
  • MORE

1 Introduction

2 Therapy Area Introduction
2.1 Symptoms
2.1.1 Pneumonia
2.1.2 RSV
2.1.3 PAH
2.1.4 Tuberculosis
2.2 Diagnosis
2.2.1 Pneumonia
2.2.2 RSV
2.2.3 PAH
2.2.4 Tuberculosis
2.3 Etiology and Pathophysiology
2.3.1 Pneumonia
2.3.2 RSV
2.3.3 PAH
2.3.4 Tuberculosis
2.4 Epidemiology
2.4.1 Pneumonia
2.4.2 RSV
2.4.3 PAH
2.4.4 Tuberculosis
2.5 Comorbidities and Complications
2.5.1 Pneumonia
2.5.2 RSV
2.5.3 PAH
2.5.4 Tuberculosis
2.6 Prognosis
2.6.1 Pneumonia
2.6.2 RSV
2.6.3 PAH
2.6.4 Tuberculosis
2.7 Treatment
2.7.1 Antibiotics
2.7.2 Antiviral Drugs
2.7.3 Vaccines
2.7.4 Antihypertensive drugs
2.7.5 Anticoagulants
2.7.6 Non-Pharmacological Treatments

3 Marketed Products
3.1 Overview
3.2 Prevnar 13 - Pfizer
3.3 Synflorix - GlaxoSmithKline
3.4 Uptravi - Actelion
3.5 Opsumit - Actelion
3.6 Eliquis - Bristol-Myers Squibb and Pfizer
3.7 Xarelto - Bayer
3.8 Synagis - Medimmune
3.9 Ventolin - GlaxoSmithKline
3.10 Infanrix and Boostrix - GlaxoSmithKline

4 Pipeline Landscape Assessment
4.1 Overview
4.2 Pipeline Development Landscape
4.3 Molecular Targets in the Pipeline
4.4 Clinical Trials
4.4.1 Failure Rate by Stage of Development, Indication, Molecule Type and Molecular Target
4.4.2 Clinical Trial Duration by Stage of Development, Indication, Molecule Type and Molecular Target
4.4.3 Clinical Trial Size by Stage of Development, Indication, Molecule Type and Molecular Target
4.4.4 Aggregate Clinical Program Size by Stage of Development, Indication, Molecule Type and Molecular Target
4.4.5 Conclusion
4.5 Assessment of Key Pipeline Products
4.5.1 Solithera - Cempra
4.5.2 Carbavance (meropenem and vaborbactam) -The Medicines Company
4.5.3 Respiratory Syncytial Virus Vaccine - Novavax
4.5.4 Conclusion

5 Multi-scenario Market Forecast to 2022
5.1 Overall Market Size
5.2 Generic Penetration
5.3 Revenue Forecast by Molecular Target and Drug Category
5.3.1 Vaccines
5.3.2 G-Protein Coupled Receptors
5.3.3 Enzyme Targets
5.3.4 Bacterial and Viral Targets
5.4 Revenue and Market Share Analysis by Company
5.4.1 Pfizer - Prevnar Dominates Respiratory Complications Revenue
5.4.2 Actelion - Rapid Growth of PAH Therapies to Create a Strong Market Position
5.4.3 GSK - Vast Product Portfolio Will Help Maintain a Strong Market Position
5.4.4 Bayer - Despite Limited Portfolio, Xarelto Performance Sufficient to Establish Strong Market Position
5.4.5 Bristol-Myers Squibb - Growing Eliquis Revenue to Improve Respiratory Complications Market Position
5.4.6 Novavax - Approval of RSV Vaccine Will Help Establish Market Presence
5.4.7 United Therapeutics - Variant Treprostinil Formulation to Form Cornerstone of Market Presence

6 Company Analysis and Positioning
6.1 Company Landscape
6.2 Marketed and Pipeline Portfolio Analysis

7 Strategic Consolidations
7.1 Licensing Deals
7.1.1 Deals by Region, Value and Year
7.1.2 Deals by Stage of Development and Value
7.1.3 Deals by Molecule Type, Mechanism of Action and Value
7.1.4 Licensing Deals Valued Above $100m
7.2 Co-development Deals
7.2.1 Deals by Region, Value and Year
7.2.2 Deals by Stage of Development and Value
7.2.3 Deals by Molecule Type and Value
7.2.4 Co-development Deals Valued Above $100m

8 Appendix
8.1 Bibliography
8.2 All Pipeline Drugs by Phase of Development
8.2.1 Discovery
8.2.2 Preclinical
8.2.3 IND/CTA-filed
8.2.4 Phase I
8.2.5 Phase II
8.2.6 Phase III
8.2.7 Pre-registration
8.2.8 Unknown
8.3 Abbreviations
8.4 Methodology
8.4.1 Coverage
8.4.2 Secondary Research
8.4.3 Market Size and Revenue Forecasts
8.4.4 Pipeline Analysis
8.4.5 Competitive Landscape

List of Tables
Table 1: Respiratory Complications Therapeutics Market, Global, Key Marketed Products and Approved Indications, 2017
Table 2: Respiratory Complications Therapeutics Market, Global, Prevnar 13 Indications, 2017
Table 3: Respiratory Complications Therapeutics Market, Global, Synflorix Indications, 2017
Table 4: Respiratory Complications Therapeutics Market, Global, Uptravi Indications, 2017
Table 5: Respiratory Complications Therapeutics Market, Global, Opsumit Indications, 2017
Table 6: Respiratory Complications Therapeutics Market, Global, Eliquis Indications, 2017
Table 7: Respiratory Complications Therapeutics Market, Global, Xarelto Indications, 2017
Table 8: Respiratory Complications Therapeutics Market, Global, Synagis Indications, 2017
Table 9: Respiratory Complications Therapeutics Market, Global, Ventolin Indications, 2017
Table 10: Respiratory Complications Therapeutics Market, Global, Infanrix Indications, 2017
Table 11: Respiratory Complications Therapeutics Market, Global, Annual Revenue Forecast for Key Products ($m), 2015-2022
Table 12: Respiratory Complications Therapeutics Market, Global, Forecast Revenue by Company, 2015-2022
Table 13: Respiratory Complications Therapeutics Market, Global, Licensing Deals Valued above $100m, 2006-2017
Table 14: Respiratory Complications Therapeutics Market, Global, Co-development Deals above $100m, 2006-2017
Table 15: Respiratory Complications Therapeutics Market, Global, Pipeline Products, Discovery, 2017
Table 16: Respiratory Complications Therapeutics Market, Global, Pipeline Products, Preclinical, 2017
Table 17: Respiratory Complications Therapeutics Market, Global, Pipeline Products, IND/CTA-Filed, 2017
Table 18: Respiratory Complications Therapeutics Market, Global, Pipeline Products, Phase I, 2017
Table 19: Respiratory Complications Therapeutics Market, Global, Pipeline Products, Phase II, 2017
Table 20: Respiratory Complications Therapeutics Market, Global, Pipeline Products, Phase III, 2017
Table 21: Respiratory Complications Therapeutics Market, Global, Pipeline Products, Pre-Registration, 2017
Table 22: Respiratory Complications Therapeutics Market, Global, Pipeline Products, Unknown, 2017

List of Figures
Figure 1: Respiratory Complications Therapeutics Market, Global, Epidemiology Patterns for Pneumonia Incidence, 2015-2022
Figure 2: Respiratory Complications Therapeutics Market, Global, Epidemiology Patterns for Pneumococcal Vaccinations (million), 2015-2022
Figure 3: Respiratory Complications Therapeutics Market, Global, Epidemiology Patterns for PAH, 2015-2022
Figure 4: Respiratory Complications Therapeutics Market, Global, Epidemiology Patterns for Tuberculosis, 2015-2022
Figure 5: Respiratory Complications Therapeutics Market, Global, Prevnar 13 Revenue Forecast, 2015-2022
Figure 6: Respiratory Complications Therapeutics Market, Global, Synflorix Revenue Forecast, 2015-2022
Figure 7: Respiratory Complications Therapeutics Market, Global, Uptravi Revenue Forecast, 2016-2022
Figure 8: Respiratory Complications Therapeutics Market, Global, Opsumit Revenue Forecast, 2015-2022
Figure 9: Respiratory Complications Therapeutics Market, Global, Eliquis Revenue Forecast, 2015-2022
Figure 10: Respiratory Complications Therapeutics Market, Global, Xarelto Revenue Forecast, 2015-2022
Figure 11: Respiratory Complications Therapeutics Market, Global, Synagis Revenue Forecast, 2015-2022
Figure 12: Respiratory Complications Therapeutics Market, Global, Ventolin Revenue Forecast, 2015-2022
Figure 13: Respiratory Complications Therapeutics Market, Global, Infanrix Revenue Forecast, 2015-2022
Figure 14: Respiratory Complications Therapeutics Market, Global, Boostrix Revenue Forecast, 2015-2022
Figure 15: Respiratory Complications Therapeutics Market, Global, Pipeline by Stage of Development, Molecule Type and Program Type, 2017
Figure 16: Respiratory Complications Therapeutics Market, Global, Pipeline for Key Indications by Stage of Development, 2017
Figure 17: Respiratory Complications Therapeutics Market, Global, Pipeline for Key Indications by Molecule Type, 2017
Figure 18: Respiratory Complications Therapeutics Market, Global, Pipeline by Molecular Target, 2017
Figure 19: Respiratory Complications Therapeutics Market, Global, Pipeline for Key Indications by Molecular Target, 2017
Figure 20: Respiratory Complications Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development (%), 2006-2017
Figure 21: Respiratory Complications Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Indication (%), 2006-2017
Figure 22: Respiratory Complications Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Molecule Type (%), 2006-2017
Figure 23: Respiratory Complications Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Molecular Target (%), 2006-2017
Figure 24: Respiratory Complications Therapeutics Market, Global, Clinical Trial Duration by Stage of Development (months), 2006-2017
Figure 25: Respiratory Complications Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Indication (months), 2006-2017
Figure 26: Respiratory Complications Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Molecule Type (months), 2006-2017
Figure 27: Respiratory Complications Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Molecular Target (months), 2006-2017
Figure 28: Respiratory Complications Therapeutics Market, Global, Clinical Trial Size by Stage of Development (participants), 2006-2017
Figure 29: Respiratory Complications Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Indication (participants), 2006-2017
Figure 30: Respiratory Complications Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Molecule Type (participants), 2006-2017
Figure 31: Respiratory Complications Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Molecular Target (participants), 2006-2017
Figure 32: Respiratory Complications Therapeutics Market, Global, Clinical Program Size by Stage of Development (participants), 2006-2017
Figure 33: Respiratory Complications Therapeutics Market, Global, Clinical Program Size by Stage of Development and Indication (participants), 2006-2017
Figure 34: Respiratory Complications Therapeutics Market, Global, Clinical Program Size by Stage of Development and Molecule Type (participants), 2006-2017
Figure 35: Respiratory Complications Therapeutics Market, Global, Clinical Program Size by Stage of Development and Molecular Target (participants), 2006-2017
Figure 36: Respiratory Complications Therapeutics Market, Global, Revenue Forecast for Solithera ($m), 2017-2022
Figure 37: Respiratory Complications Therapeutics Market, Global, Revenue Forecast for Carbavance ($m), 2017-2022
Figure 38: Respiratory Complications Therapeutics Market, Global, Revenue for Respiratory Syncytial Virus Vaccine ($m), 2018-2022
Figure 39: Respiratory Complications Therapeutics Market, Global, Market Size ($bn), 2015-2022
Figure 40: Respiratory Complications Therapeutics Market, Global, Annual Revenue by Generic Products ($m), 2015-2022
Figure 41: Respiratory Complications Therapeutics Market, Global, Annual Revenue Forecast for Vaccines ($bn), 2015-2022
Figure 42: Respiratory Complications Therapeutics Market, Global, Annual Revenue Forecast for Drugs Targeting G-Protein Coupled Receptors ($bn), 2015-2022
Figure 43: Respiratory Complications Therapeutics Market, Global, Annual Revenue Forecast for Drugs Targeting Enzymes ($bn), 2015-2022
Figure 44: Respiratory Complications Therapeutics Market, Global, Annual Revenue Forecast for Drugs with Bacterial/Viral Targets ($bn), 2015-2022
Figure 45: Respiratory Complications Therapeutics Market, Global, Company Analysis Matrix, 2015-2022
Figure 46: Respiratory Complications Therapeutics Market, Global, Forecast Market Share by Company (%), 2015-2022
Figure 47: Respiratory Complications Therapeutics Market, Global, Companies by Compound Annual Growth Rate (%), Base Year-2022
Figure 48: Respiratory Complications Therapeutics Market, Global, Pfizer Annual Revenue Forecast ($bn), 2015-2022
Figure 49: Respiratory Complications Therapeutics Market, Global, Actelion Annual Revenue ($bn), 2015-2022
Figure 50: Respiratory Complications Therapeutics Market, Global, GSK Annual Revenue ($bn), 2015-2022
Figure 51: Respiratory Complications Therapeutics Market, Global, Bayer Annual Revenue ($bn), 2015-2022
Figure 52: Respiratory Complications Therapeutics Market, Global, Bristol-Myers Squibb Annual Revenue ($bn), 2015-2022
Figure 53: Respiratory Complications Therapeutics Market, Global, Novavax Annual Revenue ($m), 2018-2022
Figure 54: Respiratory Complications Therapeutics Market, Global, United Therapeutics Annual Revenue ($bn), 2015-2022
Figure 55: Respiratory Complications Therapeutics Market, Global, Cluster by Growth and Market Share, 2015-2022
Figure 56: Respiratory Complications Therapeutics Market, Global, Companies by Type, 2017
Figure 57: Respiratory Complications Therapeutics Market, Global, High-Activity and Late-Stage Developers by Level of Specialization, 2017
Figure 58: Respiratory Complications Therapeutics Market, Global, Proportion of Total Company Revenue Attributed to Respiratory Complications, 2015-2022

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  • Actelion
  • Bayer
  • Bristol-Myers Squibb
  • GlaxoSmithKline
  • Medimmune
  • Pfizer
Note: Product cover images may vary from those shown
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Note: Product cover images may vary from those shown
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