Long Noncoding RNAs: Basic Science to Disease Biology provides an overview of the state-of-the-art methods in the field that have created an understanding of the sequence, structure, function and disease associations of lncRNAs. The decade following the availability of the reference human genome has seen tremendous advancements in the scale and throughput of nucleotide sequencing and its widespread application. This sequencing technology has allowed for rapid, advanced study of the functionalities of lncRNAs and has revealed their intricate and important roles in a variety of biological processes and pathophysiology of diseases.
- Features approaches to characterize the function of lncRNA
- Presents information on high-throughput functional screening and imaging
- Includes a chapter on RNA-Capture Seq for the annotation of lncRNAs
1. Introduction 2. Methods for discovery and annotation of long noncoding RNA 3. Long noncoding RNAs in model organisms 4. Databases and resources of long noncoding RNAs 5. Conservation and variation in lncRNAs 6. Disease associations of lncRNAs 7. Molecular dissection of lncRNA function 8. Methods to understand lncRNA function 9. LncRNAs as potential disease biomarkers and drug targets
Vinod Scaria is a medico turned bioinformatician, interested in genome analysis. He is involved in the development of bioinformatics tools and their application in several areas spanning his research interests in the prediction and design of miRNDAs, genome assembly and annotation, and the integration of genome-scale data for systems biology.