Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches.
This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.
- Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics
- Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis
- Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies
- Features contributions by leading experts in the field
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SECTION I: NON-CODING RNAs: FINE-TUNING CANCER
2. miRNA and Cancer: A Deadly Liaison?
3. Alteration of MicroRNA Biogenesis Pathways in Cancers
4. MicroRNAs In Exosomes in Cancer
5. Circulating miRNAs Incresaing the Risk of Cancer
6. Long Noncoding RNAs as Cancer Biomarkers
7. The Balancing Act: Understanding MicroRNA and Competing Endogenous RNA Regulation in Cancer
8. PIWI-Interacting RNAs (piRNAs) and Cancer
9. Transfer RNA in Cancer
10. Dynamic Regulation of tRNA Modifications in Cancer
11. Circular RNA: A Novel Noncoding RNA in Cancer
12. Antisense RNA and Cancer
13. Implication of Other Noncoding RNAs in Cancer
SECTION 2: GENETIC DYSREGULATION OF NON-CODING RNA IN CANCER
14. Noncoding RNA Alterations in Cancer Molecular Pathways
15. Genetic Alteration of MicroRNA Affecting Cancer Pathways
16. Genetic Variations of Long Noncoding RNAs in Cancer
SECTION 3: EPIGENETIC EFFECT ON CANCER THROUGH NON-CODING RNAs
17. Cross Talk Between Noncoding RNAs and DNA Methylation and Demethylation in Cancer
18. Noncoding RNAs Act as a Chromatin Scaffold of Histone Modification Complexes in Cancer
19. Heterochromatin Modulation and PcG Control of Gene Expression Medicated by Noncoding RNA in Cancer
20. Epigenetic Control of MicroRNA Expression and Cancer
21. Implications of Long Noncoding RNAs in Cancer Epigenetics
SECTION 4: THERAPEUTIC IMPLICATIONS OF NON-CODING RNA IN CANCER
22. Long Noncoding RNAs: Insight Into Their Roles in Normal and Cancer Stem Cells
23. Clinical Relevance, Prognostic Potential, and Therapeutic Strategies of Noncoding RNAs in Cancer
24. Noncoding RNAs: Novel Targets in Anticancer Drug Development
SECTION 5: BIOINFORMATICS' DETECTION OF NON-CODING RNA IN CANCER
25. Cancer Noncoding RNA Discovery Through High-Throughput Sequencing
26. Noncoding RNAs as a Cauce of Cancer: Evidence From Genome-Wide Association Studies and Reverse Genetics
27. A Comparative Evaluation of Emerging Databases and Tools for Cancer Noncoding RNAs
28. Future Directions and Challenges Involved in Cancer Noncoding RNomics
Dr. Chakrabarti earned his PhD from the City University of New York. He conducted postdoctoral training at University of Rochester, New York; the Institute of Theoretical Science in Eugene, Oregon; and the University of Bielefeld, Germany. Currently he is a Senior Lecturer at the Indian Association for the Cultivation of Science (IACS) in Kolkata, India and a Principle Investigator at Gyanxet-Beta, a commercial lab which develops tools and resources for RNA bioinformatics. Dr. Chakrabarti's research areas include the role of noncoding RNAs in human disease, specifically in viral infections and head and neck cancer, as well as stem cells and pluripotency and the development of bioinformatics tools for analyzing noncoding RNAs. He has more than fifteen years of research experience in epigenetics, focusing on noncoding RNAs, and more than twenty-five years teaching experience at IACS. In addition to his teaching and research, Dr. Chakrabarti has published more than fifty scientific papers in peer reviewed journals and has served on the editorial boards of Scientific Reports, Bioinformatics, Journal of Biomolecular Structure and Dynamics, Nucleic Acids Research, DNA Research, Human Mutations, PLOS Computational Biology, and BMC Genomics. His lab at IACS has collaborated on epigenetic research with labs at the Massachusetts Institute of Technology, University of Georgia, Stanford University, and the University of Bielefeld, among others.
Since 2010 Sanga Mitra has served as a Senior Research Fellow at the Indian Association for the Cultivation of Science (IACS) in Kolkata, India, under the mentorship of her PhD advisor, Jayprokas Chakrabarti. Her research areas within the Computational Biology group at IACS include microarray and RNA-Sequencing data analysis, histone modifications, head and neck cancer, and tRNA gene annotation. She holds an M.S. in Bioinformatics and has recently submitted her PhD dissertation, "Computational Genomics and miRNomics of Cancer. Sanga Mitra has also presented on her research at genomics, cancer, and bioinformatics conferences around the world, most notably at BIT's 3rd World DNA and Genome Day, New Horizons in Cancer Research, and the International Conference on Stem Cells and Cancer. She has published eight scientific papers to-date in peer reviewed journals including RNA and Transcription, Journal of Biomolecular Structure and Dynamics, Scientific Reports, Genomic Medicine, and Cancer Biomarkers.