Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury - from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies.
The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.
- Offers descriptions of the normal structure/function of mammalian skin, exposure to clinical problems, and more
- Presents coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) that extends to clinical requirements and skin diseases in vitro models
- Addresses legal requirements and ethical concerns in drugs and cosmetics in vitro testing
- Edited and authored by internationally renowned group of researchers, presenting the broadest coverage possible
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Therapeutic Molecules and Cosmetics Testing 1. Cosmetic industry requirements regarding skin models for cosmetic testing Christian Pellevoisin, Charbel Bouez, José Cotovio 2. Overall perspective on the clinical importance of skin models Yusef Yousuf, Saeid Amini-Nik, Marc G. Jeschke,
Skin Diseases: clinical demands and diseased-skin in vitro models 3. In vitro models of Melanoma Dagmar Kulms, Friedegund Meier 4. Organotypic and humanized animal models of genodermatoses Esteban Chacón-Solan, Sara Guerrero-Aspizua, Lucía Martínez-Santamaría, Marcela Del Rio, Fernando Larcher 5. In vitro models of Psoriasis Bryan Roy, Mélissa Simard, Isabelle Lorthois, Audrey Bélanger, Maxim Maheux, Alexandra Duque-Fernandez, Geneviève Rioux, Philippe Simard, Marianne Deslauriers, Louis-Charles Masson, Alexandre Morin and Roxane Pouliot 6. In vitro models of Vitiligo Muriel Cario-André, Katia Boniface, François-Xavier Bernard, Alain Taieb, Maria Lucia Dell'Anna, Julien Seneschal 7. In vitro models of squamous cell carcinoma Elizabeth Pavez Loriè, Hans-Jürgen Stark, Manuel Berning, Petra Boukamp
Skin Substitutes: Clinical demands and skin tissue equivalents 8. Strategies to promote the vascularization of skin substitutes after transplantation Jennifer Bourland, Julie Fradette 9. On the path to scarring-free skin regeneration approaches Mohammed Ashrafi, Adam Hague, Mohamed Baguneid, Teresa Alonso-Rasgado, Ardeshir Bayat 10. Pre-clinical Models for Wound Healing Studies Irena Pastar, Liang Liang, Andrew P Sawaya, Tongyu Cao Wikramanayake, George D Glinos, Stephan Drakulich, Vivien Chen, Olivera Stojadinovic, Stephen C Davis, and Marjana Tomic-Canic 11. The importance of targeting inflammation in skin regeneration Megan Schrementi, Lin Chen, Luisa Ann DiPietro
In Vitro Models as study platforms of skin Biology 12. In Vitro Models to study hair follicles generation Ana Korosec, Beate Maria Lichtenberger 13. In Vitro Models to study cutaneous innervation mechanisms Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Jérémy Chéret, Raphaël Leschiera, Matthieu Talagas, Raphaële Le Garrec, Virginie Buhé, Killian L'herondelle, Olivier Gouin, Mehdi Sakka, Nicholas Boulais, Ulysse Pereira, Jean-Luc Carré, Laurent Misery 14. Skin in vitro models to study dermal white adipose tissue role in skin healing Manuela E. L. Lago, Mariana T. Cerqueira, Rogério P. Pirraco, Rui L. Reis, Alexandra P. Marques 15. Immunocompetent in vitro skin models Victoria Hutter, Stewart B Kirton, David YS Chau
Emerging technologies for the development of 3D skin models 16. Additive manufacturing in the development of 3D skin models Kelsey Retting, Deborah G. Nguyen 17. Induced Pluripotent Stem Cells Potential to generate skin tissue models Olga Kashpur, Avi Smith, Nailia Mukhamedshina, Jeremy Baskin, Yulia Shamis, Kyle Hewitt, Behzad Gerami-Naini, Jonathan A. Garlick 18. Requirements of skin tissue models for high throughput screening Stephanie H. Mathes, Christian N. Parker
Alexandra Pinto Marques graduated in Biochemistry (1997) in the Faculty of Sciences of the University of Porto, Portugal, attended a one year specialisation course as part of the Biomedical Engineering Master/Doctoral Programme at the Faculty of Engineering of the University of Porto (1998) and obtained a PhD in Materials Science and Technology - Biomaterials in the University of Minho, Portugal and in cooperation with the University of Liverpool, UK (2004). She is Principal Investigator, a founder member and Vice-Director of the 3B's Research Group, a Research Unit of the University of Minho, Portugal, where she has been build her career in the field of skin tissue engineering. She has been integrating stem cells and biomaterials knowledge into tissue engineering as a way to define innovative strategies to improve the functionality of skin tissue engineered constructs. The establishment of in vitro 3D culture platforms to understand cellular crosstalk as well to be able to modulate the engineered constructs outcome has been the focus of her work. She has been awarded successive career grants among which a Consolidator Grant from the European Research Council (2016).
Reis, Rui L
Rui L. Reis, PhD, DSc, Hon. Causa MD, FBSE, FTERM, member of NAE, is the Director of the 3B's Research Group and of the ICVS/3B´s Associate Laboratory of the University of Minho. He is also the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Global President of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He is a recognized World expert, with almost a 1000 published works and more than 25000 citations to his work, in the development of biomaterials from natural origin polymers and their use in tissue engineering and regenerative medicine, and in controlled drug delivery, in many cases in combination with different types of stem cells. He has been awarded many international prizes and is the PI of projects with a budget totalizing more than 40 million Euros.
Pirraco, Rogério P.
Rogério P. Pirraco (born 1982 Porto, Portugal) concluded his four year-graduation in Applied Biology in 2005, at the University of Minho and his PhD at the same university in 2011. During his PhD, he spent a total of one year at Professor Teruo Okano's Institute of Advanced Biomedical Engineering and Science of the Tokyo's Women Medical University in Tokyo, Japan, where he acquired knowledge in cell sheet engineering and its application in animal models. In 2016, Rogério got a 5 year FCT IF contract (career development grant from the Portuguese Science and Technology Agency) that will allow him to pursue his research interests in an independent way. Currently, his research interests are focused on the use of cell sheet engineering, stem cells and hypoxia for Tissue Engineering strategies.
Mariana T. Cerqueira (born in 1983 in Porto, Portugal) concluded four years graduation in Biology (2006), in the Faculty of Sciences of the University of Porto, performing a final work thesis at Stem Cell Laboratory, King's College London, UK, where she got the opportunity of the first contact with the latest cutting edge research. She carried out her academic career by joining 3B's Research Group, University of Minho, where she concluded a PhD in Tissue Engineering, Regenerative Medicine and Stem Cells (2013), as the first graduated student in the field of Skin Regeneration in the group and where she has been working since then. After concluding a Post-Doctoral fellowship awarded by Portuguese Foundation of Science and Technology, Mariana currently works as an Invited Assistant Researcher. By taking advantage of the knowledge acquainted during graduate studies and novel collaborations established, she has been focused on the development of different skin tissue engineering strategies by exploring mainly stem cell-based approaches to fine tune their role in different types of wounds. She has been publishing several works in refereed journals, awarded two front covers in international journals, and in international conference proceedings.