Milestones in Immunology: Based on Collected Papers contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers working in the field of immunology. As the science of immunology grew from knowledge that survivors of common infectious diseases rarely contracted them again, the book uses this as a central thesis, helping readers understand how the adaptive immune system aids in defense against pathogens. In addition, the book covers special fields, such as immunohistochemistry, immunogenetics and immunopathology.
For the past century, immunology has fascinated and inspired some of the greatest scientists of our time. Numerous Nobel Prizes have been awarded for fundamental discoveries in immunology, from Paul Ehrlich' work on antibodies (1908) to the studies of Zinkernagel and Doherty (1986) elucidating mechanisms of cell-mediated immunity.
- Provides on update on developments since the publication of Nobel prize winning research for fundamental discoveries in immunology
- Discusses the changing theories and technologies that guided the field
- Lists all the important discoveries and books in the field
- Explains, in detail, the many Nobel prize-winning contributions of immunologists
- Provides recognition of the scientists who were pioneers of landmark discoveries in immunology
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1. Paul Ehrlich's doctoral thesis: a milestone in the study of mast cells 2. Miller'seminal studies on the role of thymus in immunity 3. The contribution of Bruce Glick to the definition of the role played by the bursa of Fabricius in the development of the B cell lineage 4. The fundamental contribution of Robert A. Good to the discovery of the crucial role of thymus in mammalian immunity 5. Giulio Bizzozero and the discovery of platelets 6. Sir Frank Macfarlane Burnet and the clonal selection theory of antibody formation 7. The embryonic origins of lymphatic vessels: an historical review 8. The fundamental contribution of William Bate Hardy to shape the concept of mast cell heterogeneity 9. The mast cell: an evolutionary perspective 10. From the discovery of monoclonal antibodies to their therapeutic application: an historical reappraisal 11. Max D. Cooper and the delineation of two lymphoid lineages in the adaptive immune system 12. Edelman's view on the discovery of antibodies 13. Peter Brain Medawar and the discovery of acquired immunological tolerance 14. The discovery of blood-thymus barrier
Domenico Ribatti was born in Andria, Italy, on December 27, 1956. He was awarded his M.D. degree on October 1981, with full marks. In 1983, Dr. Ribatti joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy from the University of Timisoara (Romania). His present position is full professor of Human Anatomy at the University of Bari Medical School. Domenico Ribatti is author of 718 publications as reported in PubMed and contributed to 50 chapters to books. With Dr. Francesco Pezzella, Dr. Ribatti co-edited the book Tumor Vascularization, to be published on February 2020.