In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available.
Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling.
- Provides information on the most common assays to study angiogenesis in vivo
- Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development
- Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant
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The corneal micropocket assay
The zebrafish embryo
The sponge implant method
The Matrigen implant assay
In vivo gene transfer with AAV vectors
In vivo tumor models
Domenico Ribatti is Professor of Human Anatomy, in the Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy. He was awarded his M.D. degree in 1981, with full marks. In 1983, he joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology. In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara, Romania. He is the author of over 800 publications and 50 chapters, as well as a number of books for Elsevier/Academic Press including:
Milestones in Immunology (2017)
In Vivo Models to Study Angiogenesis (2017)
Immunology in the Twentieth Century (2018)
Tumor Vascularization (2020)
Tumor Microenvironment Regulation of Tumor Expansion (2021) .