Toxicology Cluster Chemotherapy Related Toxicity Drug Development Pipeline Review, 2017

  • ID: 4258947
  • Report
  • Region: Global
  • 139 Pages
  • GBI Research
1 of 5

FEATURED COMPANIES

  • 3SBio Inc
  • Biocon Ltd
  • Genexine Inc
  • Metys Pharmaceuticals AG
  • PeriphaGen Inc
  • Serina Therapeutics Inc
  • MORE

Toxicology Cluster Chemotherapy Related Toxicity Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the toxicology pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for Chemotherapy Induced Nausea and Vomiting, Chemotherapy Induced Neutropenia, Chemotherapy Induced Anemia, Chemotherapy Induced Peripheral Neuropathy and features dormant and discontinued projects.

Chemotherapy induced nausea and vomiting or CINV is nausea and vomiting that results specifically from treatment with chemotherapy drugs. There are a total of 28 products in development for this indication, by 20 companies. Key companies operating in this pipeline space include Helsinn, Luxena Pharmaceuticals, Aphios, Nemus Bioscience and Tesaro.

Chemotherapy-induced neutropenia is a very common side effect of cancer treatment. Symptoms include severe fatigue, weakness, anxiety, lack of energy, shortness of breath, headaches, pale appearance, rapid heart rate or palpitations, chest pain dizziness and abdominal pain. There are a total of 41 products in development for this indication, by 31 companies and one academic institution. Key companies operating in this pipeline space include Bolder Biotechnology, USV, Apotex, Biocon, Biogenomics, Generon and Pfizer.

Chemotherapy-induced anemia is a very common side effect of cancer treatment. Symptoms include severe fatigue, weakness, anxiety, lack of energy, shortness of breath, headaches, pale appearance, rapid heart rate or palpitations, chest pain dizziness, cognitive impairment, loss of sexual desire, inability to perform daily functions and/or depression associated with anemia. There are a total of 16 products in development for this indication, by 14 companies. Key companies operating in this pipeline space include Chong Kun Dang and Tolero Pharmaceuticals.

Finally, chemotherapy-induced peripheral neuropathy (CIPN) is a further potential side effect of cancer treatment. Symptoms include pain, burning, tingling, constipation, muscle weakness, blood pressure changes and balance problems. There are a total of 41 products in development for this indication, by 34 companies and four academic institutions. Key companies operating in this pipeline space include Apexian Pharmaceuticals, Celgene and Metys Pharmaceuticals.

The dominant molecular targets vary across each of the four pipelines. In CINV and CIPN, there is a relatively diverse range of targets which are being studied. The 5-hydroxytryptamine receptor 3 and substance P receptors are most commonly being studied in CINV, as are the cannabinoid receptors 1 and 2. There is some overlap between this and the CIPN pipeline, with cannabinoid receptors being present amongst the relatively diverse range of targets in development, although with the glutamate ionotropic receptor NMDA-type being the most-frequently selected target.

In chemotherapy-induced neutropenia, on the other hand, the granulocyte colony stimulating factor receptor is overwhelmingly the target of choice, accounting for virtually the entire pipeline. Similarly, the erythropoietin receptor makes up the majority of the chemotherapy-induced anemia pipeline. This reflects the relatively focused nature of R&D within these two indications.

Scope

  • Which companies are the most active within the pipeline for toxicology therapeutics?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in the field of toxicology therapeutics?

Reasons to buy

  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration.
READ MORE
Note: Product cover images may vary from those shown
2 of 5

FEATURED COMPANIES

  • 3SBio Inc
  • Biocon Ltd
  • Genexine Inc
  • Metys Pharmaceuticals AG
  • PeriphaGen Inc
  • Serina Therapeutics Inc
  • MORE

1. Report Guidance

2. Executive Summary

3. Introduction

4. Toxicology Cluster Chemotherapy Related Toxicity Report Coverage

  • Chemotherapy Induced Nausea and Vomiting - Overview
  • Chemotherapy Induced Neutropenia - Overview
  • Chemotherapy Induced Anemia - Overview
  • Chemotherapy Induced Peripheral Neuropathy - Overview

5. Therapeutics Development

  • Chemotherapy Induced Nausea and Vomiting
  • Chemotherapy Induced Neutropenia
  • Chemotherapy Induced Anemia
  • Chemotherapy Induced Peripheral Neuropathy

6. Therapeutics Assessment

  • Chemotherapy Induced Nausea and Vomiting
  • Chemotherapy Induced Neutropenia
  • Chemotherapy Induced Anemia
  • Chemotherapy Induced Peripheral Neuropathy

7. Companies Involved in Therapeutics Development

  • Chemotherapy Induced Nausea and Vomiting
  • Chemotherapy Induced Neutropenia
  • Chemotherapy Induced Anemia
  • Chemotherapy Induced Peripheral Neuropathy

8. Dormant Projects

  • Chemotherapy Induced Nausea and Vomiting
  • Chemotherapy Induced Neutropenia
  • Chemotherapy Induced Anemia
  • Chemotherapy Induced Peripheral Neuropathy

9. Discontinued Products

  • Chemotherapy Induced Nausea and Vomiting
  • Chemotherapy Induced Neutropenia
  • Chemotherapy Induced Anemia
  • Chemotherapy Induced Peripheral Neuropathy

10. Product Development Milestones

  • Chemotherapy Induced Nausea and Vomiting
  • Chemotherapy Induced Neutropenia
  • Chemotherapy Induced Anemia
  • Chemotherapy Induced Peripheral Neuropathy

11. Appendix

  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation

List of Tables

  • Number of Products under Development for Chemotherapy Induced Nausea and Vomiting
  • Number of Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting
  • Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting
  • Number of Products under Development for Chemotherapy Induced Neutropenia
  • Number of Products under Development by Companies, Chemotherapy Induced Neutropenia
  • Number of Products under Development by Universities/Institutes, Chemotherapy Induced Neutropenia
  • Products under Development by Companies, Chemotherapy Induced Neutropenia
  • Products under Development by Universities/Institutes, Chemotherapy Induced Neutropenia
  • Number of Products under Development for Chemotherapy Induced Anemia
  • Number of Products under Development by Companies, Chemotherapy Induced Anemia
  • Products under Development by Companies, Chemotherapy Induced Anemia
  • Number of Products under Development for Chemotherapy Induced Peripheral Neuropathy
  • Number of Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy
  • Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy
  • Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Target, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Route of Administration, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Molecule Type, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Target, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Route of Administration, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Molecule Type, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Target, Chemotherapy Induced Anemia
  • Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Anemia
  • Number of Products by Stage and Route of Administration, Chemotherapy Induced Anemia
  • Number of Products by Stage and Molecule Type, Chemotherapy Induced Anemia
  • Number of Products by Stage and Target, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Route of Administration, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Molecule Type, Chemotherapy Induced Peripheral Neuropathy
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Acacia Pharma Ltd
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Aphios Corp
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Astellas Pharma Inc
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Camurus AB
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Daewoong Pharmaceutical Co Ltd
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Heron Therapeutics Inc
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by INSYS Therapeutics Inc
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Kyowa Hakko Kirin Co Ltd
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by MannKind Corp
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Medlab Clinical Ltd
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Nemus Bioscience Inc
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by RedHill Biopharma Ltd
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Serina Therapeutics Inc
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by SoluBest Ltd
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Suda Ltd
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Tesaro Inc
  • Chemotherapy Induced Nausea and Vomiting - Pipeline by Therapix Biosciences Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Apotex Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Biocon Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Biogenomics Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Bolder Biotechnology Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Cellerant Therapeutics Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Chong Kun Dang Pharmaceutical Corp
  • Chemotherapy Induced Neutropenia - Pipeline by Cinfa Biotech SL
  • Chemotherapy Induced Neutropenia - Pipeline by Dr. Reddy's Laboratories Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Gene Techno Science Co Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Generon (Shanghai) Corp Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Genexine Inc
  • Chemotherapy Induced Neutropenia - Pipeline by GlycoMimetics Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Hanmi Pharmaceuticals Co Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Mycenax Biotech Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Myelo Therapeutics GmbH
  • Chemotherapy Induced Neutropenia - Pipeline by Nohla Therapeutics Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Octapharma AG
  • Chemotherapy Induced Neutropenia - Pipeline by Pfenex Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Pfizer Inc
  • Chemotherapy Induced Neutropenia - Pipeline by Reliance Life Sciences Pvt Ltd
  • Chemotherapy Induced Neutropenia - Pipeline by Richter Gedeon Nyrt
  • Chemotherapy Induced Neutropenia - Pipeline by Sandoz International GmbH
  • Chemotherapy Induced Neutropenia - Pipeline by USV Pvt Ltd
  • Chemotherapy Induced Anemia - Pipeline by 3SBio Inc
  • Chemotherapy Induced Anemia - Pipeline by Chong Kun Dang Pharmaceutical Corp
  • Chemotherapy Induced Anemia - Pipeline by Dr. Reddy's Laboratories Ltd
  • Chemotherapy Induced Anemia - Pipeline by Galenica Ltd
  • Chemotherapy Induced Anemia - Pipeline by Novartis AG
  • Chemotherapy Induced Anemia - Pipeline by Panacea Biotec Ltd
  • Chemotherapy Induced Anemia - Pipeline by Pfizer Inc
  • Chemotherapy Induced Anemia - Pipeline by PharmaEssentia Corp
  • Chemotherapy Induced Anemia - Pipeline by PhytoHealth Corp
  • Chemotherapy Induced Anemia - Pipeline by Pieris Pharmaceuticals Inc
  • Chemotherapy Induced Anemia - Pipeline by SBI Pharmaceuticals Co Ltd
  • Chemotherapy Induced Anemia - Pipeline by Therapure Biopharma Inc
  • Chemotherapy Induced Anemia - Pipeline by Tolero Pharmaceuticals Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Achelios Therapeutics Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Advinus Therapeutics Ltd
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Apollo Endosurgery Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Aptinyx Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Asahi Kasei Pharma Corp
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Can-Fite BioPharma Ltd
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Celgene Corp
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by DermaXon LLC
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Eisai Co Ltd
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Immune Pharmaceuticals Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by INSYS Therapeutics Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Kineta Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by KPI Therapeutics Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Krenitsky Pharmaceuticals Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by MAKScientific LLC
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Metys Pharmaceuticals AG
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Midatech Pharma US Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Mundipharma International Ltd
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Nemus Bioscience Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Neurocentrx Pharma Ltd
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Panacea Pharmaceuticals Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by PeriphaGen Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by PharmatrophiX Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by PledPharma AB
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Sova Pharmaceuticals Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by Virobay Inc
  • Chemotherapy Induced Peripheral Neuropathy - Pipeline by WEX Pharmaceuticals Inc
  • Chemotherapy Induced Nausea and Vomiting - Dormant Projects
  • Chemotherapy Induced Neutropenia - Dormant Projects
  • Chemotherapy Induced Anemia - Dormant Projects
  • Chemotherapy Induced Peripheral Neuropathy - Dormant Projects
  • Chemotherapy Induced Nausea and Vomiting - Discontinued Products
  • Chemotherapy Induced Neutropenia - Discontinued Products
  • Chemotherapy Induced Anemia - Discontinued Products
  • Chemotherapy Induced Peripheral Neuropathy - Discontinued Products

List of Figures

  • Number of Products under Development for Chemotherapy Induced Nausea and Vomiting
  • Number of Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting
  • Number of Products under Development for Chemotherapy Induced Neutropenia
  • Number of Products under Development by Companies, Chemotherapy Induced Neutropenia
  • Number of Products under Development for Chemotherapy Induced Anemia
  • Number of Products under Development by Companies, Chemotherapy Induced Anemia
  • Number of Products under Development for Chemotherapy Induced Peripheral Neuropathy
  • Number of Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Targets, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Targets, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Mechanism of Actions, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Top 10 Routes of Administration, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Top 10 Routes of Administration, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Stage and Molecule Types, Chemotherapy Induced Nausea and Vomiting
  • Number of Products by Targets, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Targets, Chemotherapy Induced Neutropenia
  • Number of Products by Mechanism of Actions, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Neutropenia
  • Number of Products by Routes of Administration, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Routes of Administration, Chemotherapy Induced Neutropenia
  • Number of Products by Molecule Types, Chemotherapy Induced Neutropenia
  • Number of Products by Stage and Molecule Types, Chemotherapy Induced Neutropenia
  • Number of Products by Targets, Chemotherapy Induced Anemia
  • Number of Products by Stage and Targets, Chemotherapy Induced Anemia
  • Number of Products by Mechanism of Actions, Chemotherapy Induced Anemia
  • Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Anemia
  • Number of Products by Routes of Administration, Chemotherapy Induced Anemia
  • Number of Products by Stage and Routes of Administration, Chemotherapy Induced Anemia
  • Number of Products by Molecule Types, Chemotherapy Induced Anemia
  • Number of Products by Stage and Molecule Types, Chemotherapy Induced Anemia
  • Number of Products by Top 10 Targets, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Top 10 Targets, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Top 10 Mechanism of Actions, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Top 10 Mechanism of Actions, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Routes of Administration, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Routes of Administration, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Molecule Types, Chemotherapy Induced Peripheral Neuropathy
  • Number of Products by Stage and Molecule Types, Chemotherapy Induced Peripheral Neuropathy
Note: Product cover images may vary from those shown
3 of 5

Loading
LOADING...

4 of 5
  • 3SBio Inc
  • Acacia Pharma Ltd
  • Achelios Therapeutics Inc
  • Advinus Therapeutics Ltd
  • Aphios Corp
  • Apollo Endosurgery Inc
  • Apotex Inc
  • Aptinyx Inc
  • Asahi Kasei Pharma Corp
  • Astellas Pharma Inc
  • Biocon Ltd
  • Biogenomics Ltd
  • Bolder Biotechnology Inc
  • Camurus AB
  • Can-Fite BioPharma Ltd
  • Celgene Corp
  • Cellerant Therapeutics Inc
  • Chong Kun Dang Pharmaceutical Corp
  • Cinfa Biotech SL
  • Daewoong Pharmaceutical Co Ltd
  • DermaXon LLC
  • Dr. Reddy's Laboratories Ltd
  • Eisai Co Ltd
  • Galenica Ltd
  • Gene Techno Science Co Ltd
  • Generon (Shanghai) Corp Ltd
  • Genexine Inc
  • GlycoMimetics Inc
  • Hanmi Pharmaceuticals Co Ltd
  • Heron Therapeutics Inc
  • INSYS Therapeutics Inc
  • Immune Pharmaceuticals Inc
  • KPI Therapeutics Inc
  • Kineta Inc
  • Krenitsky Pharmaceuticals Inc
  • Kyowa Hakko Kirin Co Ltd
  • MAKScientific LLC
  • MannKind Corp
  • Medlab Clinical Ltd
  • Metys Pharmaceuticals AG
  • Midatech Pharma US Inc
  • Mundipharma International Ltd
  • Mycenax Biotech Inc
  • Myelo Therapeutics GmbH
  • Nemus Bioscience Inc
  • Neurocentrx Pharma Ltd
  • Nohla Therapeutics Inc
  • Novartis AG
  • Octapharma AG
  • Panacea Biotec Ltd
  • Panacea Pharmaceuticals Inc
  • PeriphaGen Inc
  • Pfenex Inc
  • Pfizer Inc
  • PharmaEssentia Corp
  • PharmatrophiX Inc
  • PhytoHealth Corp
  • Pieris Pharmaceuticals Inc
  • PledPharma AB
  • RedHill Biopharma Ltd
  • Reliance Life Sciences Pvt Ltd
  • Richter Gedeon Nyrt
  • SBI Pharmaceuticals Co Ltd
  • Sandoz International GmbH
  • Serina Therapeutics Inc
  • SoluBest Ltd
  • Sova Pharmaceuticals Inc
  • Suda Ltd
  • Tesaro Inc
  • Therapix Biosciences Ltd
  • Therapure Biopharma Inc
  • Tolero Pharmaceuticals Inc
  • USV Pvt Ltd
  • Virobay Inc
  • WEX Pharmaceuticals Inc
Note: Product cover images may vary from those shown
5 of 5
Note: Product cover images may vary from those shown
Adroll
adroll