Platform Technologies in Drug Discovery and Validation, Vol 50. Annual Reports in Medicinal Chemistry

  • ID: 4288436
  • Book
  • 690 Pages
  • Elsevier Science and Technology
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Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides.

  • Unique for its treatment of platform technologies for medicinal chemistry and target validation
  • Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field
  • Presents state-of-the-art summaries of platform technologies
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1. DNA-Encoded Library Technology: A Brief Guide to Its Evolution and Impact on Drug Discovery

Robert A. Goodnow Jr. and Christopher P. Davie

2. The Chemistry of Oligonucleotide Delivery

David B. Rozema

3. CRISPR-Cas9 for Drug Discovery in Oncology

Sylvie M. Guichard

4. Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry

László Ürge, Jesus Alcazar, Lena Huck and György Dormán

5. High-Throughput Screening

Mary Jo Wildey, Anders Haunso, Matthew Tudor, Maria Webb and Jonathan H. Connick

6. Kinase-Centric Computational Drug Development

Albert J. Kooistra and Andrea Volkamer

7. Free Energy Calculation Guided Virtual Screening of Synthetically Feasible Ligand R-Group and Scaffold Modifications: An Emerging Paradigm for Lead Optimization

Robert Abel and Sathesh Bhat

8. Phenotypic Screening

Alleyn T. Plowright and Lauren Drowley

9. Targeted Protein Degradation

Nello Mainolfi and Tim Rasmusson

10. Chemical Biology in Drug Discovery

M. Paola Castaldi, Andrea Zuhl, Piero Ricchiuto and J. Adam Hendricks

11. Fragment-Based Lead Discovery

Ben J. Davis and Stephen D. Roughley

12. Antibody-Drug Conjugates

Amit Kumar, Jason White, R. James Christie, Nazzareno Dimasi and Changshou Gao

13. Antibody-Recruiting Small Molecules: Synthetic Constructs as Immunotherapeutics

Patrick J. McEnaney, Christopher G. Parker and Andrew X. Zhang

14. A Decade of Deuteration in Medicinal Chemistry

Julie F. Liu, Scott L. Harbeson, Christopher L. Brummel, Roger Tung, Robert Silverman and Dario Doller

15. From Natural Peptides to Market

Claudio D. Schteingart and Jolene L. Lau
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