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Protein Therapeutics. 2 Volume Set. Methods and Principles in Medicinal Chemistry

  • ID: 4290580
  • Book
  • September 2017
  • 768 Pages
  • John Wiley and Sons Ltd
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In this practice–oriented handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and other professionals working in drug development.

Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non–human antibodies to antibody mimetics, bispecific antibodies and antibody–drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune–oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.
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Contents to Volume 1

Preface XVII

A Personal Foreword XXI

Acknowledgements XXIII

Part I Introduction to Protein Therapeutics: Past and Present 1

1 Early Recombinant Protein Therapeutics 3
Pierre De Meyts

2 Evolution of Antibody Therapeutics 25
Hervé Watier and Janice M. Reichert

Part II Antibodies: The Ultimate Scaffold for Protein Therapeutics 51

3 Human Antibody Structure and Function 53
Ponraj Prabakaran and Dimiter S. Dimitrov

4 Antibodies from Other Species 85
Melissa L. Vadnais, Michael F. Criscitiello, and Vaughn V. Smider

Part III Discovery and Engineering of Protein Therapeutics 113

5 Human Antibody Discovery Platforms 115
William R. Strohl

6 Beyond Antibodies: Engineered Protein Scaffolds for Therapeutic Development 161
Nishant K. Mehta and Jennifer R. Cochran

7 Protein Engineering: Methods and Applications 189
Claire Dobson

8 Bispecifics 229
Jijie Gu, Andrew McCluskey, and Tariq Ghayur

9 Antibody–drug Conjugates (ADCs) 271
Dr Philip W. Howard

Contents to Volume 2

Preface XVII

A Personal Foreword XXI

Acknowledgements XXIII

Part IV Physiological and Manufacturing Considerations for Biologics 311

10 Pharmacokinetics of Therapeutic Proteins 313
Zheng Lu, Jennifer Sheng, and Wenhui Zhang

References 334

11 Safety Considerations for Biologics 341
Maggie Dempster, Lucinda R. Weir, and Rajni S. Fagg

12 Immunogenicity of Biologics 387
Matthew P. Baker, Timothy D. Jones, and Paul Chamberlain

13 Expression Systems for Recombinant Biopharmaceutical Production by Mammalian Cells in Culture 423
Adam J. Brown, Devika Kalsi, Alejandro Fernandez–Martell, Joe Cartwright, Nicholas O. W. Barber, Yash D. Patel, Richard Turner, Claire L. Bryant, Yusuf B. Johari, and David C. James

Abbreviations 450

References 452

14 Stability, Formulation, and Delivery of Biopharmaceuticals 469
Hanns–Christian Mahler and Andrea Allmendinger

Part V Clinical Applications 493

15 Protein Therapeutics in Autoimmune and Inflammatory Diseases 495
Anthony J. Coyle and Leigh S. Zawel

References 511

16 Antibody–Based Therapeutics in Oncology 521
Paul A. Moore, Ross La Motte–Mohs, Jonathan C. Li, and Gurunadh R. Chichili

17 Protein Therapeutics in Respiratory Medicine 587
Rahul Shrimanker and Ian D. Pavord

18 Antibodies for the Prevention, Treatment, and Preemption of Infectious Diseases 611
Steve Projan

19 Rescue Therapies 621
Stephan Glund

20 Biosimilars 645
Jun Wang

Part VI Future Horizons 661

21 Future Horizons and New Target Class Opportunities 663
Herren Wu, Carl Webster, Judy Paterson, Sandrine Guillard, Ron Jackson, and Ralph Minter

References 690

Index 701

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Tristan Vaughan
Jane Osbourn
Bahija Jallal
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