3D Cell Cultures: Technologies and Global Markets

  • ID: 4296712
  • Report
  • Region: Global
  • 290 Pages
  • BCC Research
15 % OFF
until Dec 31st 2018
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The Three-Dimensional Cell Culture Market Reached $1.0 Billion in 2016 and Should Reach $3.9 Billion in 2021, with a CAGR of 42.6%

FEATURED COMPANIES

  • 3D Biomatrix Inc.
  • Alpco
  • Cell Applications Inc.
  • Emulate Inc.
  • Kiyatec Inc.
  • Perkinelmer
  • MORE

Report Includes

  • An overview of the global markets and technologies for 3D cell cultures.
  • Analyses of global market trends, with data from 2015, estimates for 2016, and projections of compound annual growth rates (CAGRs) through 2021.
  • Information on 3D technologies, with a focus on representative platforms, including cube, spherical droplet, stacked plate, magnetic bead, and other platforms.
  • Value-chain analysis at the following levels: key innovation or founding intellectual property, prototyping, beta testing, and research collaborations or relationship building.
  • Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities.
  • Relevant patent analysis, including recent activity and a list of key patents.
  • Profiles of major players in the industry.

Report Scope

The scope of the report encompasses the major types of 3D cell culture that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • 3D Biomatrix Inc.
  • Alpco
  • Cell Applications Inc.
  • Emulate Inc.
  • Kiyatec Inc.
  • Perkinelmer
  • MORE

1: Introduction

  • Study Goals and Objectives
  • Reasons for Doing the Study
  • Scope of Report
  • Intended Audience
  • Methodology and Information Sources

2: Summary and Highlights

  • New Applications Identified Since 2015 Report
  • Changes from 2015 Report

3: Market and Technology Background

  • Tissue and Cell Culture
  • Tissue
  • Cells
  • Tissue Culture and Cell Culture Definitions
  • Obtaining Cell Cultures
  • Cell Types Based on Morphology
  • Cell Types Based on Hybridomas
  • Cell Culture: Basic Requirements
  • Basic Cell Culture Systems
  • History and Early Applications

4: Tissue and Cell Culture Systems Landscape

  • Large-Scale Manufacture of Biopharmaceuticals and Vaccines
  • Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues
  • Technology Overview by Cell Culture Type
  • Adherent Approaches
  • Three-dimensional Bioreactors
  • Applications in Regenerative Medicine
  • Tissue Culture - Early 3D Pioneers
  • Revenue Estimate
  • Table 3 : Cell Culture Applications

5: Research Landscape and Products Used in Three-dimensional Cell Culture

  • Microplates
  • Cellomics Overview
  • Two-dimensional Cultures vs. Three-dimensional Cultures
  • Basic 3D Cell Culture Variables
  • High Throughput Screening (HTS) Applications
  • 3D Assay Open Innovation Platform

6: Three-dimensional Technologies and Basic Products

  • Microtiter Plates Provide Platform
  • Three-dimensional Cell Culture Technologies
  • Importance of 2D vs. 3D Systems
  • Basic 3D Cell Culture Variables
  • Three-dimensional Technology and Products
  • Organs and Organoids
  • Tissue Engineering in Regenerative Medicine
  • Skin Substitutes Industry
  • U.S. Regulatory Status of Bioprinted Products
  • Organ Transplants
  • Acquisitions and Strategic Alliances
  • Revenue Summary
  • Market Estimate

7: Three-dimensional Models for Cancer

  • Cancer at the Cellular Level Overview
  • Approaches to Date
  • In Vivo (Animal) Testing Standard
  • Three-dimensional Requirements
  • Three-dimensional Benefits to Cancer Research
  • Breast Cancer as a Driver of Three-dimensional Cultures
  • Melanoma as a Driver of Three-dimensional Cultures
  • Three-dimensional Systems in Cancer Research
  • Three-dimensional Engineered Scaffolds
  • Learnings from Drug Sensitivity and Resistance
  • Cellular Signaling
  • Drug Screening
  • Cancer Metabolism
  • Future Horizons
  • Patient-derived Cells
  • Evolution of PDX Platforms
  • Ex Vivo Models
  • Combining Ex Vivo with NGS
  • Revenue Forecast

8: Landscape for Toxicology and Drug Safety Testing

  • Toxicology Background
  • Efficacy of Cosmetics and Cosmeceuticals
  • Bioprinting
  • Chronic and Repeated Dose Toxicity
  • Carcinogenicity and Genotoxicity
  • Reproductive and Developmental Toxicity
  • Endocrine Disruptor Screening
  • Toxicokinetics and ADME
  • In Vitro Developments
  • Organotypic Models
  • Absorption Barrier Models
  • Liver Toxicity
  • Uniqueness and Complexity of Liver
  • Liver as a Key Driver for Three-dimensional Innovation
  • In Vitro Liver Applications
  • In Vivo Liver Function and Structure
  • Liver Metabolism
  • Liver In Vitro Models
  • Co-Cultures of Hepatocytes and Macrophages
  • Three-dimensional Liver Models
  • Bioprinted Liver Tissue
  • Detected Hepatosphere Structures and Functionality
  • Ideal Criteria
  • Drug Resistance
  • Transporter Studies
  • Achieving Heterotypic Cell-cell Contacts
  • Summary Learnings
  • Unmet Needs and Future Drivers of Innovation
  • Morphogen Signaling
  • Microfluidics Applications
  • Multi-Donor Liver Cells
  • Kidney Toxicity Applications
  • Future Challenge: Stem-Cell Derived Kidney Cells
  • Pancreatic Toxicology Applications
  • Cardiovascular Safety Testing of New Drug Candidates
  • Revenue Estimate

9: 3D Culture Role in Stem Cells

  • Introduction
  • Early Learnings
  • Embryogenesis
  • Three-dimensional Stem Cell Culture Systems
  • Controlling Embryoid Body Formation
  • Applications
  • Status and Drivers
  • Fujifilm (Cellular Dynamics Inc.)
  • Breakthroughs Resulting from Stem Cells Research
  • Revenue Estimate

10: Three-dimensional Next-Generation Outlook

  • Overview
  • Cancer
  • Predictive Toxicology
  • Stem Cells for Neuroscience Discovery and Development
  • Stem Cells for Cardiovascular Discovery
  • Stem Cells for Development of Regenerative Medicine
  • Revenue Estimate
  • Chapter Appendix: Liver

11: Company Profiles

  • 3D Biomatrix Inc.
  • 3D Biotek Llc
  • 3D Cell Technologies Llc
  • 4D Technology
  • Abcam
  • Akron Biotechnology Llc
  • Amsbio Llc
  • Agilent Technologies
  • Alpco
  • Applikon Biotechnology
  • Beckman Coulter Life Sciences
  • Biogelx Ltd.
  • Bioinspired Solutions
  • Biotime Inc.
  • Biovision Inc.
  • Cell Applications Inc.
  • Cellink
  • Cellspring
  • Corning Life Sciences
  • Cyprotex Plc
  • Cytoo Sa
  • EMD Millipore
  • Emulate Inc.
  • Epithelix Sarl
  • GE Healthcare Life Sciences
  • Greiner Bio-One
  • Hamilton Robotics
  • Hubrecht Organoid Technology
  • Hurel Corp.
  • Insphero AG
  • Invitrocue Ltd.
  • Kiyatec Inc.
  • Lifenet Health
  • Mattek Corp.
  • Mimetas Inc.
  • Mitra Biotech Inc.
  • N3D Biosciences Inc.
  • National Center For Advancing Translational Sciences (Ncats)
  • Organovo
  • Perkinelmer
  • Plasticell Ltd.
  • Pluristem Therapeutics, Inc.
  • Poietis SAS
  • Promega Corp.
  • Qualyst Transporter Solutions Llc.
  • Screen Holdings Co. Ltd.
  • Solidus Biosciences Inc.
  • Stemcell Technologies Inc.
  • Stratatech Corp.
  • Synvivo Inc.
  • Tap Biosystems
  • Tecan Group Ltd.
  • Thermo Fisher Scientific
  • Zen-Bio Inc.

12: Appendix: Patent Analysis
Table 44 : Patents Assigned in 3D Cell Culture, 2009-2017

List of Tables

Summary Table : Global Three-dimensional Cell Culture Market, Through 2021
Table 1 : Tissue Types
Table 2 : Cell Types
Table 3 : Cell Culture Applications
Table 4 : Leading Bioreactor Suppliers, 2017
Table 5 : Leading Tissue Products and Suppliers, October 2016
Table 6 : Global Market for Three-dimensional Bioreactors and Microcarriers, Through 2021
Table 7 : High-Content Screening Suppliers and Key Attributes, January 2017
Table 8 : Label-Free Technologies and Suppliers, January 2017
Table 9 : Automated Patch Clamping Companies and Technologies, January 2017
Table 10 : Leading Cell Line Suppliers, January 2017
Table 11 : Leading Primary Cell Suppliers, January 2017
Table 12 : Leading Stem Cell Suppliers, January 2017
Table 13 : Typical Assay Endpoints and Tests
Table 14 : Organ-On-Chip Industry
Table 15 : Bioprinting Instrument Technologies
Table 16 : Maintaining Cell Viability During Printing
Table 17 : Bioprinting Instrument Industry
Table 18 : Bioink Components
Table 19 : Bioink Types
Table 20 : Matrix Bioink Hydrogel Classes
Table 21 : Matrix Bioink Selection Criteria
Table 22 : Selected Bioink Companies
Table 23 : In Vitro Testing in Cosmetics
Table 24 : Bioprinting Industry Alliances in Cosmetics, 2015
Table 25 : Printed Tissue and Organs: Commercialization Timeframe
Table 26 : Tissue/Organ Complexity
Table 27 : Skin Substitute Products and Market Focus
Table 28 : U.S. Regulatory Considerations
Table 29 : Number of United States Organ Transplants, January-June 2016
Table 30 : Bioprinting Industry Acquisitions and Strategic Alliances, January 2014-February 2016
Table 31 : Leading Reagent, Media and Microplate Suppliers, January 2017
Table 32 : Three-dimensional Technology Product Market, Through 2021 ($ Millions)
Table 33 : Common Three-dimensional Assays
Table 34 : Three-dimensional Tumor Models Developed for Drug Discovery, June 2017
Table 35 : Summary of EV3D Benefits/Advantages
Table 36 : Global Market for Three-dimensional Culture Used in Cancer Drug Development, Through 2021
Table 37 : In Vitro Testing in Cosmetics
Table 38 : Alliances Between Bioprinting and Cosmetics Companies, 2015
Table 39 : In Vitro and In Vivo Assays in the Tier 1 Screening Battery, January 2014
Table 40 : Global Market for Three-dimensional Cultures Used in Predictive Tox Applications, Through 2021
Table 41 : Global Market for Three-dimensional Cultures Used in Stem Cell Research Applications, Through 2021
Table 42 : New Applications That Have Emerged Since the 2015 Report
Table 43 : Global Market for Next-Generation 3D Applications, Through 2021
Table 44 : Patents Assigned in 3D Cell Culture, 2009-2017

List of Figures

Summary Figure : Global Three-dimensional Cell Culture Market, 2015-2021
Figure 1 : Technology Maturity

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FEATURED COMPANIES

  • 3D Biomatrix Inc.
  • Alpco
  • Cell Applications Inc.
  • Emulate Inc.
  • Kiyatec Inc.
  • Perkinelmer
  • MORE

Analyst Credentials:

Robert G. Hunter is a senior management consultant, commercialization consultant and technology and market analyst with over 20 years of experience in life sciences and healthcare. Recent consulting includes market/technology analysis and forecasting of customer adoption and revenue for a high content screening (HCS) technology leader. He is an early investor in a company using stem cells for predictive drug safety testing in vitro. He has a B.S. in Mechanical Engineering from Clemson University and Master of Business Administration from The Tuck School of Business at Dartmouth.

Note: Product cover images may vary from those shown
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  • 3D Biomatrix Inc.
  • 3D Biotek Llc
  • 3D Cell Technologies Llc
  • 4D Technology
  • Abcam
  • Akron Biotechnology Llc
  • Amsbio Llc
  • Agilent Technologies
  • Alpco
  • Applikon Biotechnology
  • Beckman Coulter Life Sciences
  • Biogelx Ltd.
  • Bioinspired Solutions
  • Biotime Inc.
  • Biovision Inc.
  • Cell Applications Inc.
  • Cellink
  • Cellspring
  • Corning Life Sciences
  • Cyprotex Plc
  • Cytoo Sa
  • EMD Millipore
  • Emulate Inc.
  • Epithelix Sarl
  • GE Healthcare Life Sciences
  • Greiner Bio-One
  • Hamilton Robotics
  • Hubrecht Organoid Technology
  • Hurel Corp.
  • Insphero AG
  • Invitrocue Ltd.
  • Kiyatec Inc.
  • Lifenet Health
  • Mattek Corp.
  • Mimetas Inc.
  • Mitra Biotech Inc.
  • N3D Biosciences Inc.
  • National Center For Advancing Translational Sciences (Ncats)
  • Organovo
  • Perkinelmer
  • Plasticell Ltd.
  • Pluristem Therapeutics, Inc.
  • Poietis Sas
  • Promega Corp.
  • Qualyst Transporter Solutions Llc.
  • Screen Holdings Co. Ltd.
  • Solidus Biosciences Inc.
  • Stemcell Technologies Inc.
  • Stratatech Corp.
  • Synvivo Inc.
  • Tap Biosystems
  • Tecan Group Ltd.
  • Thermo Fisher Scientific
  • Zen-Bio Inc.
Note: Product cover images may vary from those shown
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Note: Product cover images may vary from those shown
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