Skeletal Disease Drug Development Pipeline Review, 2017

  • ID: 4327948
  • Report
  • Region: Global
  • 176 Pages
  • GBI Research
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FEATURED COMPANIES

  • AbbVie Inc
  • Bone Biologics Corp
  • Evgen Pharma Plc
  • Ipsen SA
  • Nordic Bioscience A/S
  • ProteoThera Inc
  • MORE

Summary

This report provides an overview of the skeletal disease pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for osteoporosis, post-menopausal osteoporosis and osteoarthritis (OA).

OA is one of the most common forms of arthritis. It is a chronic condition in which the cartilage breaks down. There are a total of 116 products in development for this indication, by 87 companies and 8 academic institutions. Key companies operating in this pipeline space include Arcarios, Nordic Bioscience, Rottapharm Biotech and the University of Toledo.

Osteoporosis, or thinning bones, makes bones weak and more likely to break. Risk factors for osteoporosis include aging, being female, low body weight, low sex hormones or menopause, smoking, and some medications. There are a total of 112 products in development for this indication, by 80 companies and 16 academic institutions. Key companies operating in this pipeline space include Max Biopharma, Omeros, Affilogic laboratories, Amgen and the University of Wisconsin Madison.

Postmenopausal osteoporosis is the most common form of osteoporosis. It affects many women after menopause. There are a total of 13 products in development for this indication, by ten companies. Key companies operating in this pipeline space include Amgen and Ipsen.

The predominant targets within OA are prostaglandin G/H synthases 1 and 2, although a wide range of targets, including extracellular matrix-organizing proteins and interleukins, are being studied. Likewise, within both osteoporosis and the post-menopausal subtype, a broad range of molecular targets are being studied. The targets being most frequently studied are the parathyroid hormone receptor, tumor necrosis factor ligand superfamily member 11 and sclerostin.

Scope

  • Which companies are the most active within the pipeline for osteoporosis and OA therapeutics?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in the field of osteoporosis and OA therapeutics?

Reasons to buy

  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration.
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Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • AbbVie Inc
  • Bone Biologics Corp
  • Evgen Pharma Plc
  • Ipsen SA
  • Nordic Bioscience A/S
  • ProteoThera Inc
  • MORE

1. Research Report Guidance

2. Executive Summary

3. Introduction

4. Skeletal Disease Report Coverage

  • Osteoarthritis - Overview
  • Osteoporosis - Overview
  • Post Menopausal Osteoporosis - Overview

5. Therapeutics Development

  • Osteoarthritis
  • Osteoporosis
  • Post Menopausal Osteoporosis

6. Therapeutics Assessment

  • Osteoarthritis
  • Osteoporosis
  • Post Menopausal Osteoporosis

7. Companies Involved in Therapeutics Development

  • Osteoarthritis
  • Osteoporosis
  • Post Menopausal Osteoporosis

8. Dormant Projects

  • Osteoarthritis
  • Osteoporosis
  • Post Menopausal Osteoporosis

9. Discontinued Products

  • Osteoarthritis
  • Osteoporosis
  • Post Menopausal Osteoporosis

10. Product Development Milestones

  • Osteoarthritis
  • Osteoporosis
  • Post Menopausal Osteoporosis

11. Appendix

  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation

List of Tables

  • Number of Products under Development for Osteoarthritis
  • Number of Products under Development by Companies, Osteoarthritis
  • Number of Products under Development by Universities/Institutes, Osteoarthritis
  • Products under Development by Companies, Osteoarthritis
  • Products under Development by Universities/Institutes, Osteoarthritis
  • Number of Products under Development for Osteoporosis
  • Number of Products under Development by Companies, Osteoporosis
  • Number of Products under Development by Universities/Institutes, Osteoporosis
  • Products under Development by Companies, Osteoporosis
  • Products under Development by Universities/Institutes, Osteoporosis
  • Number of Products under Development for Post Menopausal Osteoporosis
  • Number of Products under Development by Companies, Post Menopausal Osteoporosis
  • Products under Development by Companies, Post Menopausal Osteoporosis
  • Number of Products by Stage and Target, Osteoarthritis
  • Number of Products by Stage and Mechanism of Action, Osteoarthritis
  • Number of Products by Stage and Route of Administration, Osteoarthritis
  • Number of Products by Stage and Molecule Type, Osteoarthritis
  • Number of Products by Stage and Target, Osteoporosis
  • Number of Products by Stage and Mechanism of Action, Osteoporosis
  • Number of Products by Stage and Route of Administration, Osteoporosis
  • Number of Products by Stage and Molecule Type, Osteoporosis
  • Number of Products by Stage and Target, Post Menopausal Osteoporosis
  • Number of Products by Stage and Mechanism of Action, Post Menopausal Osteoporosis
  • Number of Products by Stage and Route of Administration, Post Menopausal Osteoporosis
  • Number of Products by Stage and Molecule Type, Post Menopausal Osteoporosis
  • Osteoarthritis - Pipeline by A. Menarini Industrie Farmaceutiche Riunite Srl
  • Osteoarthritis - Pipeline by AbbVie Inc
  • Osteoarthritis - Pipeline by Abiogen Pharma SpA
  • Osteoarthritis - Pipeline by Ablynx NV
  • Osteoarthritis - Pipeline by Achelios Therapeutics Inc
  • Osteoarthritis - Pipeline by Addex Therapeutics Ltd
  • Osteoarthritis - Pipeline by Amgen Inc
  • Osteoarthritis - Pipeline by Amura Holdings Ltd
  • Osteoarthritis - Pipeline by Arcarios BV
  • Osteoarthritis - Pipeline by Asahi Kasei Pharma Corp
  • Osteoarthritis - Pipeline by Asklepios BioPharmaceutical Inc
  • Osteoarthritis - Pipeline by Astellas Pharma Inc
  • Osteoarthritis - Pipeline by Biopharm GmbH
  • Osteoarthritis - Pipeline by Bone Therapeutics SA
  • Osteoarthritis - Pipeline by Can-Fite BioPharma Ltd
  • Osteoarthritis - Pipeline by Cardax Inc
  • Osteoarthritis - Pipeline by Cellular Biomedicine Group Inc
  • Osteoarthritis - Pipeline by Cipla Ltd
  • Osteoarthritis - Pipeline by Corestem Inc
  • Osteoarthritis - Pipeline by Dong-A Socio Holdings Co Ltd
  • Osteoarthritis - Pipeline by Evgen Pharma Plc
  • Osteoarthritis - Pipeline by F. Hoffmann-La Roche Ltd
  • Osteoarthritis - Pipeline by Galapagos NV
  • Osteoarthritis - Pipeline by Gemphire Therapeutics Inc
  • Osteoarthritis - Pipeline by GeneFrontier Corp
  • Osteoarthritis - Pipeline by Genequine Biotherapeutics GmbH
  • Osteoarthritis - Pipeline by GlaxoSmithKline Plc
  • Osteoarthritis - Pipeline by HSRx Group
  • Osteoarthritis - Pipeline by InKemia IUCT Group SA
  • Osteoarthritis - Pipeline by International Stem Cell Corp
  • Osteoarthritis - Pipeline by Jeil Pharmaceutical Co Ltd
  • Osteoarthritis - Pipeline by Jenrin Discovery Inc
  • Osteoarthritis - Pipeline by K-Stemcell Co Ltd
  • Osteoarthritis - Pipeline by Kang Stem Biotech Co Ltd
  • Osteoarthritis - Pipeline by Levolta Pharmaceuticals Inc
  • Osteoarthritis - Pipeline by LG Chem, Ltd.
  • Osteoarthritis - Pipeline by Marina Biotech Inc
  • Osteoarthritis - Pipeline by Medivir AB
  • Osteoarthritis - Pipeline by Merck KGaA
  • Osteoarthritis - Pipeline by Mesoblast Ltd
  • Osteoarthritis - Pipeline by Mor Research Application Ltd
  • Osteoarthritis - Pipeline by NicOx SA
  • Osteoarthritis - Pipeline by Nordic Bioscience A/S
  • Osteoarthritis - Pipeline by Novartis AG
  • Osteoarthritis - Pipeline by NovelMed Therapeutics Inc
  • Osteoarthritis - Pipeline by Omeros Corp
  • Osteoarthritis - Pipeline by Ono Pharmaceutical Co Ltd
  • Osteoarthritis - Pipeline by OrthoCyte Corp
  • Osteoarthritis - Pipeline by Osteologix Holdings Plc
  • Osteoarthritis - Pipeline by Pfizer Inc
  • Osteoarthritis - Pipeline by Pharmalink AB
  • Osteoarthritis - Pipeline by Philogen SpA
  • Osteoarthritis - Pipeline by PhytoHealth Corp
  • Osteoarthritis - Pipeline by PLx Pharma Inc
  • Osteoarthritis - Pipeline by ProteoThera Inc
  • Osteoarthritis - Pipeline by Regeneus Ltd
  • Osteoarthritis - Pipeline by Regulaxis SAS
  • Osteoarthritis - Pipeline by Rottapharm Biotech Srl
  • Osteoarthritis - Pipeline by Samumed LLC
  • Osteoarthritis - Pipeline by Seikagaku Corp
  • Osteoarthritis - Pipeline by Stelis Biopharma Pvt Ltd
  • Osteoarthritis - Pipeline by Takeda Pharmaceutical Company Ltd
  • Osteoarthritis - Pipeline by TissueGene Inc
  • Osteoarthritis - Pipeline by Yooyoung Pharmaceutical Co Ltd
  • Osteoarthritis - Pipeline by Yuhan Corp
  • Osteoarthritis - Pipeline by Yungjin Pharm Co Ltd
  • Osteoarthritis - Pipeline by Zimmer Biomet Holdings Inc
  • Osteoporosis - Pipeline by Addex Therapeutics Ltd
  • Osteoporosis - Pipeline by Alize Pharma SAS
  • Osteoporosis - Pipeline by Alvogen Korea Co Ltd
  • Osteoporosis - Pipeline by Amgen Inc
  • Osteoporosis - Pipeline by Amura Holdings Ltd
  • Osteoporosis - Pipeline by BiologicsMD Inc
  • Osteoporosis - Pipeline by Bone Biologics Corp
  • Osteoporosis - Pipeline by Bristol-Myers Squibb Company
  • Osteoporosis - Pipeline by Cellmid Ltd
  • Osteoporosis - Pipeline by ChoDang Pharm Co Ltd
  • Osteoporosis - Pipeline by Chugai Pharmaceutical Co Ltd
  • Osteoporosis - Pipeline by Corium International Inc
  • Osteoporosis - Pipeline by Critical Pharmaceuticals Ltd
  • Osteoporosis - Pipeline by Daiichi Sankyo Company Ltd
  • Osteoporosis - Pipeline by ElexoPharm GmbH
  • Osteoporosis - Pipeline by EndoCeutics Inc
  • Osteoporosis - Pipeline by Entera Bio Ltd
  • Osteoporosis - Pipeline by Enteris BioPharma Inc
  • Osteoporosis - Pipeline by Enzo Biochem Inc
  • Osteoporosis - Pipeline by F. Hoffmann-La Roche Ltd
  • Osteoporosis - Pipeline by Gador SA
  • Osteoporosis - Pipeline by GL Pharm Tech Corp
  • Osteoporosis - Pipeline by Glide Pharmaceutical Technologies Ltd
  • Osteoporosis - Pipeline by Hanmi Pharmaceuticals Co Ltd
  • Osteoporosis - Pipeline by Haoma Medica Ltd
  • Osteoporosis - Pipeline by Immunovo BV
  • Osteoporosis - Pipeline by Immunwork Inc
  • Osteoporosis - Pipeline by Intas Pharmaceuticals Ltd
  • Osteoporosis - Pipeline by Ipsen SA
  • Osteoporosis - Pipeline by Kaken Pharmaceutical Co Ltd
  • Osteoporosis - Pipeline by Lead Discovery Center GmbH
  • Osteoporosis - Pipeline by Ligand Pharmaceuticals Inc
  • Osteoporosis - Pipeline by Lotus Pharmaceutical Co Ltd
  • Osteoporosis - Pipeline by Lupin Ltd
  • Osteoporosis - Pipeline by Merck & Co Inc
  • Osteoporosis - Pipeline by Mereo Biopharma Group Plc
  • Osteoporosis - Pipeline by NIBEC
  • Osteoporosis - Pipeline by Omeros Corp
  • Osteoporosis - Pipeline by Oncobiologics Inc
  • Osteoporosis - Pipeline by Osteologix Holdings Plc
  • Osteoporosis - Pipeline by Paras Biopharmaceuticals Finland Oy
  • Osteoporosis - Pipeline by Pfenex Inc
  • Osteoporosis - Pipeline by PhytoHealth Corp
  • Osteoporosis - Pipeline by R Pharm
  • Osteoporosis - Pipeline by Ribomic Inc
  • Osteoporosis - Pipeline by Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd
  • Osteoporosis - Pipeline by Shin Poong PharmCo Ltd
  • Osteoporosis - Pipeline by Sinil Pharmaceutical Co Ltd
  • Osteoporosis - Pipeline by Stelis Biopharma Pvt Ltd
  • Osteoporosis - Pipeline by Sumitomo Dainippon Pharma Co Ltd
  • Osteoporosis - Pipeline by Terpenoid Therapeutics Inc
  • Osteoporosis - Pipeline by TSH Biopharm Corporation Ltd
  • Osteoporosis - Pipeline by Uni-Bio Science Group Ltd
  • Osteoporosis - Pipeline by Viking Therapeutics Inc
  • Osteoporosis - Pipeline by Wroclawskie Centrum Badan EIT+ Sp z oo
  • Osteoporosis - Pipeline by Yooyoung Pharm Co Ltd
  • Osteoporosis - Pipeline by Zydus Cadila Healthcare Ltd
  • Post Menopausal Osteoporosis - Pipeline by Amgen Inc
  • Post Menopausal Osteoporosis - Pipeline by Enteris BioPharma Inc
  • Post Menopausal Osteoporosis - Pipeline by Intas Pharmaceuticals Ltd
  • Post Menopausal Osteoporosis - Pipeline by Ipsen SA
  • Post Menopausal Osteoporosis - Pipeline by Ligand Pharmaceuticals Inc
  • Post Menopausal Osteoporosis - Pipeline by Lupin Ltd
  • Post Menopausal Osteoporosis - Pipeline by NIBEC
  • Post Menopausal Osteoporosis - Pipeline by Oncobiologics Inc
  • Post Menopausal Osteoporosis - Pipeline by Paras Biopharmaceuticals Finland Oy
  • Osteoarthritis - Dormant Projects
  • Osteoporosis - Dormant Projects
  • Post Menopausal Osteoporosis - Dormant Projects
  • Osteoarthritis - Discontinued Products
  • Osteoporosis - Discontinued Products
  • Post Menopausal Osteoporosis - Discontinued Products

List of Figures

  • Number of Products under Development for Osteoarthritis
  • Number of Products under Development by Companies, Osteoarthritis
  • Number of Products under Development by Universities/Institutes, Osteoarthritis
  • Number of Products under Development for Osteoporosis
  • Number of Products under Development by Companies, Osteoporosis
  • Number of Products under Development by Universities/Institutes, Osteoporosis
  • Number of Products under Development for Post Menopausal Osteoporosis
  • Number of Products under Development by Companies, Post Menopausal Osteoporosis
  • Number of Products by Top 10 Targets, Osteoarthritis
  • Number of Products by Stage and Top 10 Targets, Osteoarthritis
  • Number of Products by Top 10 Mechanism of Actions, Osteoarthritis
  • Number of Products by Stage and Top 10 Mechanism of Actions, Osteoarthritis
  • Number of Products by Routes of Administration, Osteoarthritis
  • Number of Products by Stage and Routes of Administration, Osteoarthritis
  • Number of Products by Top 10 Molecule Types, Osteoarthritis
  • Number of Products by Stage and Top 10 Molecule Types, Osteoarthritis
  • Number of Products by Top 10 Targets, Osteoporosis
  • Number of Products by Stage and Top 10 Targets, Osteoporosis
  • Number of Products by Top 10 Mechanism of Actions, Osteoporosis
  • Number of Products by Stage and Top 10 Mechanism of Actions, Osteoporosis
  • Number of Products by Top 10 Routes of Administration, Osteoporosis
  • Number of Products by Stage and Top 10 Routes of Administration, Osteoporosis
  • Number of Products by Top 10 Molecule Types, Osteoporosis
  • Number of Products by Stage and Top 10 Molecule Types, Osteoporosis
  • Number of Products by Targets, Post Menopausal Osteoporosis
  • Number of Products by Stage and Targets, Post Menopausal Osteoporosis
  • Number of Products by Mechanism of Actions, Post Menopausal Osteoporosis
  • Number of Products by Stage and Mechanism of Actions, Post Menopausal Osteoporosis
  • Number of Products by Routes of Administration, Post Menopausal Osteoporosis
  • Number of Products by Stage and Routes of Administration, Post Menopausal Osteoporosis
  • Number of Products by Molecule Types, Post Menopausal Osteoporosis
  • Number of Products by Stage and Molecule Types, Post Menopausal Osteoporosis
Note: Product cover images may vary from those shown
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  • A. Menarini Industrie Farmaceutiche Riunite Srl
  • AbbVie Inc
  • Abiogen Pharma SpA
  • Ablynx NV
  • Achelios Therapeutics Inc
  • Addex Therapeutics Ltd
  • Alize Pharma SAS
  • Alvogen Korea Co Ltd
  • Amgen Inc
  • Amura Holdings Ltd
  • Arcarios BV
  • Asahi Kasei Pharma Corp
  • Asklepios BioPharmaceutical Inc
  • Astellas Pharma Inc
  • BiologicsMD Inc
  • Biopharm GmbH
  • Bone Biologics Corp
  • Bone Therapeutics SA
  • Bristol-Myers Squibb Company
  • Can-Fite BioPharma Ltd
  • Cardax Inc
  • Cellmid Ltd
  • Cellular Biomedicine Group Inc
  • ChoDang Pharm Co Ltd
  • Chugai Pharmaceutical Co Ltd
  • Cipla Ltd
  • Corestem Inc
  • Corium International Inc
  • Critical Pharmaceuticals Ltd
  • Daiichi Sankyo Company Ltd
  • Dong-A Socio Holdings Co Ltd
  • ElexoPharm GmbH
  • EndoCeutics Inc
  • Entera Bio Ltd
  • Enteris BioPharma Inc
  • Enzo Biochem Inc
  • Evgen Pharma Plc
  • F. Hoffmann-La Roche Ltd
  • GL Pharm Tech Corp
  • Gador SA
  • Galapagos NV
  • Gemphire Therapeutics Inc
  • GeneFrontier Corp
  • Genequine Biotherapeutics GmbH
  • GlaxoSmithKline Plc
  • Glide Pharmaceutical Technologies Ltd
  • HSRx Group
  • Hanmi Pharmaceuticals Co Ltd
  • Haoma Medica Ltd
  • Immunovo BV
  • Immunwork Inc
  • InKemia IUCT Group SA
  • Intas Pharmaceuticals Ltd
  • International Stem Cell Corp
  • Ipsen SA
  • Jeil Pharmaceutical Co Ltd
  • Jenrin Discovery Inc
  • K-Stemcell Co Ltd
  • Kaken Pharmaceutical Co Ltd
  • Kang Stem Biotech Co Ltd
  • LG Chem, Ltd.
  • Lead Discovery Center GmbH
  • Levolta Pharmaceuticals Inc
  • Ligand Pharmaceuticals Inc
  • Lotus Pharmaceutical Co Ltd
  • Lupin Ltd
  • Marina Biotech Inc
  • Medivir AB
  • Merck & Co Inc
  • Merck KGaA
  • Mereo Biopharma Group Plc
  • Mesoblast Ltd
  • Mor Research Application Ltd
  • NIBEC
  • NicOx SA
  • Nordic Bioscience A/S
  • Novartis AG
  • NovelMed Therapeutics Inc
  • Omeros Corp
  • Oncobiologics Inc
  • Ono Pharmaceutical Co Ltd
  • OrthoCyte Corp
  • Osteologix Holdings Plc
  • PLx Pharma Inc
  • Paras Biopharmaceuticals Finland Oy
  • Pfenex Inc
  • Pfizer Inc
  • Pharmalink AB
  • Philogen SpA
  • PhytoHealth Corp
  • ProteoThera Inc
  • R Pharm
  • Regeneus Ltd
  • Regulaxis SAS
  • Ribomic Inc
  • Rottapharm Biotech Srl
  • Samumed LLC
  • Seikagaku Corp
  • Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd
  • Shin Poong PharmCo Ltd
  • Sinil Pharmaceutical Co Ltd
  • Stelis Biopharma Pvt Ltd
  • Sumitomo Dainippon Pharma Co Ltd
  • TSH Biopharm Corporation Ltd
  • Takeda Pharmaceutical Company Ltd
  • Terpenoid Therapeutics Inc
  • TissueGene Inc
  • Uni-Bio Science Group Ltd
  • Viking Therapeutics Inc
  • Wroclawskie Centrum Badan EIT+ Sp z oo
  • Yooyoung Pharm Co Ltd
  • Yooyoung Pharmaceutical Co Ltd
  • Yuhan Corp
  • Yungjin Pharm Co Ltd
  • Zimmer Biomet Holdings Inc
  • Zydus Cadila Healthcare Ltd
Note: Product cover images may vary from those shown
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Note: Product cover images may vary from those shown
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