Europe Market Report for Bone Morphogenic Protein Growth Factor Therapy 2017 - MedCore - Product Image

Europe Market Report for Bone Morphogenic Protein Growth Factor Therapy 2017 - MedCore

  • ID: 4328000
  • Report
  • Region: Europe
  • 465 pages
  • iData Research
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FEATURED COMPANIES

  • Anika Therapeutics
  • Croma-Pharma
  • Ferring
  • Integra Biologics
  • LCA Pharma
  • Orotech
  • MORE
General Report Contents:
  • Market Analyses include: Unit Sales, ASPs, Market Value & Growth Trends
  • Market Drivers & Limiters for each chapter segment
  • Competitive Analysis for each chapter segment
  • Section on recent mergers & acquisitions
Scope: 2013-2023

This market went through a decline a result of Olympus exiting the market with its OP-1® BMP-7 product. However, the market has stabilized and is expected to a growth over the forecast period. Despite the recently acquired approval for Infuse® to be used as an adjunct in all spinal interbody fusion procedures, the level of absorption will remain limited due to the two products’ substantially different indications. As such, unless InductOS® can build upon its indications, the market is expected to grow at a slower rate over the forecast period.

In addition to the market value, the contracting ASP was also a result of the discontinuation of OP-1®, which was sold at a premium compared to InductOS®. Prices will remain stable throughout the remainder of the forecast period as Medtronic has no immediate plans to change its pricing scheme for the product. Furthermore, with the newly monopolized market, it is expected that demand for the product will remain fairly inelastic to any changes in price.

The countries with the largest BMP market in 2016 were France and Germany, with France being the leader. The negotiated reimbursement in France has allowed it to secure a large share of the overall European market. Germany, the largest country by population, was the second largest consumer; penetrating the German market remains difficult as Medtronic is tasked with proactively negotiating the reimbursement rates with various health insurers. Meanwhile, Austria and Portugal remained the smallest of the markets.

Bone morphogenetic proteins (BMPs) are growth factors that induce the formation of bone after a fracture. In nature, these proteins have a critical role during embryonic development in the formation of the skeleton. There are twenty different BMPs that have been discovered thus far, of which only two, BMP-2 and BMP-7, have been commercialized as bone graft substitutes for use in specific orthopedic procedures. The commercial versions of these products are produced by recombinant genetic engineering, which results in a recombinant human protein. The recombinant human BMP-2 (rhBMP-2) is marketed as a commercial product by Medtronic, Inc. and is called Infuse® (InductOS® in Europe), while BMP-7 has been commercialized by Stryker Inc. and is sold to Olympus under the name of OP-1®. Both molecules mediate the process of osteoblast differentiation. BMP-2 is capable of stimulating immature mesenchymal cells to form into bone, while BMP-7 has been shown to be capable of stimulating cartilage growth.
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Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Anika Therapeutics
  • Croma-Pharma
  • Ferring
  • Integra Biologics
  • LCA Pharma
  • Orotech
  • MORE
Executive Summary
European Orthopedic Biomaterials Market Overview
Competitive Analysis
Market Trends
Market Developments
Markets Included
Key Report Updates
Version History


1. Research Methodology
1.1 Research Scope
1.2 9-Step Methodology
Step 1: Project Initiation & Team Selection
Step 2: Prepare Data Systems and Perform Secondary Research
Step 3: Preparation for Interviews & Questionnaire Design
Step 4: Performing Primary Research
Step 5: Research Analysis: Establishing Baseline Estimates
Step 6: Market Forecast and Analysis
Step 7: Identify Strategic Opportunities
Step 8: Final Review and Market Release
Step 9: Customer Feedback and Market Monitoring

2. Disease Overview
2.1 Basic Anatomy
2.1.1 Osteology and Musculoskeletal System
2.2 Disease Pathology and Disorders
2.2.1 General Diagnostic
2.2.2 Osteoporosis
2.2.3 Osteoarthritis
2.2.4 Indication for Bone Graft Procedure
2.2.5 Indication for Cartilage Repair
2.2.6 Degenerative Disc Disease
2.3 Patient Demographics
2.3.1 General Statistics

3. Product Assessment
3.1 Product Portfolios
3.1.1 Growth Factors
3.1.1.1 Other Products
3.2 Regulatory Issues and Recalls
3.2.1 Growth Factors
3.3 Clinical Trials
3.3.1 Growth Factors

4. Country Profiles
4.1 Introduction
4.1.1 Population
4.1.2 GDP Per Capita
4.1.3 Price Index
4.2 Germany
4.3 France
4.4 United Kingdom
4.5 Italy
4.6 Spain
4.7 Benelux
4.8 Scandinavia
4.9 Austria
4.10 Switzerland
4.11 Portugal

5. Bone Morphogenetic Protein Growth Factor Therapy Market
5.1 Introduction
5.2 Market Analysis and Forecast
5.3 Drivers and Limiters
5.3.1 Market Drivers
5.3.2 Market Limiters
5.4 Competitive Market Share Analysis

Abbreviations

Appendix: Company Press Releases

List of Charts:
Chart 1 1: Orthopedic Biomaterials Market by Segment, Europe, 2013 - 2023
Chart 1 2: Orthopedic Biomaterials Market Overview, Europe, 2016 & 2023
Chart 4 1: Country Profile, Germany, 2016
Chart 4 2: Country Profile, France, 2016
Chart 4 3: Country Profile, United Kingdom, 2016
Chart 4 4: Country Profile, Italy, 2016
Chart 4 5: Country Profile, Spain, 2016
Chart 4 6: Country Profile, Benelux, 2016
Chart 4 7: Country Profile, Scandinavia, 2016
Chart 4 8: Country Profile, Austria, 2016
Chart 4 9: Country Profile, Switzerland, 2016
Chart 4 10: Country Profile, Portugal, 2016
Chart 5 1: Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2013 - 2023
Chart 5 2: Leading Competitors, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2016

List of Figures:
Figure 1 1: Orthopedic Biomaterials Market Share Ranking by Segment, Europe, 2016
Figure 1 2: Companies Researched in this Report, Europe, 2016
Figure 1 3: Factors Impacting the Orthopedic Biomaterials Market by Segment, Europe
Figure 1 4: Recent Events in the Orthopedic Biomaterials Market, Europe, 2015 - 2016
Figure 1 5: Orthopedic Biomaterials Markets Covered, Europe, 2016 (1 of 2)
Figure 1 6: Orthopedic Biomaterials Markets Covered, Europe, 2016 (2 of 2)
Figure 1 7: Key Report Updates
Figure 1 8: Version History
Figure 3 1: Growth Factors Products by Company
Figure 3 2: Class 2 Device Recall Infuse(R) Bone Graft
Figure 3 3: Class 2 Device Recall Stryker Biotech
Figure 3 4: a Study of Infuse Bone Graft (Bmp-2) in the Treatment of Tibial Pseudarthrosis in Neurofibromatosis Type 1
Figure 3 5: a Prospective Study of Instrumented, Posterolateral Lumbar Fusions (Plf) With Osteoamp®
Figure 3 6: the Clinical Effect of I-Factor® Versus Allograft in Non-Instrumented Posterolateral Spondylodesis Operation
Figure 3 7: Clinical Study of Infuse® Bone Graft Compared to Autogenous Bone Graft for Vertical Ridge Augmentation
Figure 3 8: Rct of Attrax® Putty vs. Autograft in Instrumented Posterolateral Spinal Fusion (Axa)
Figure 3 9: Clinical Study of Injectable Ceramics Bone Graft Substitute Containing Rhbmp-2
Figure 3 10: Prospective Study of Safety and Efficacy of Inqu® Bone Graft Extender in Lumbar Interbody Fusion Surgery (Intebody)
Figure 3 11: Long-Term Safety and Effectiveness of Augment® Bone Graft Compared to Autologous Bone Graft
Figure 3 12: Rhbmp-2 vs Autologous Bone Grafting for the Treatment of Non-Union of the Docking Site in Tibial Bone Transport
Figure 3 13: Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal Surgery
Figure 5 1: Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2013 - 2023
Figure 5 2: Units Sold by Country, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2013 - 2023
Figure 5 3: Average Selling Price by Country, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2013 - 2023 (€)
Figure 5 4: Average Selling Price by Country, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2013 - 2023 (Us$)
Figure 5 5: Market Value by Country, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2013 - 2023 (€M)
Figure 5 6: Market Value by Country, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2013 - 2023 (Us$M)
Figure 5 7: Drivers and Limiters, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe, 2016
Figure 5 8: Leading Competitors, Bone Morphogenetic Protein Growth Factor Therapy Market, Europe 2016
Figure 7 1: Press Release Summary
Note: Product cover images may vary from those shown
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  • Fidia
  • Medtronic
  • TRB Chemedica
  • Meda Pharma
  • Sanofi Genzyme
  • Depuy Synthes
  • Bioventus
  • Laboratoire Genevrier
  • Recordati
  • Stryker
  • RTI Biologics
  • Croma-Pharma
  • Zimmer Biomet
  • Anika Therapeutics
  • Bioiberica
  • Documedica
  • Ferring
  • Geistlich
  • Integra Biologics
  • Kuros
  • LCA Pharma
  • Orotech
  • Plasmaconcept AG
  • Stella PharmaceuticalsAlphatec Spine
Note: Product cover images may vary from those shown
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Note: Product cover images may vary from those shown
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