RNAi Technology - 2017: Insect and Pest Control, Disease and Weed Control, Crop Enhancement, Formulation and Delivery, Patents, Safety and Regulations, Company Profiles, Specialist Institutes

  • ID: 4330575
  • Report
  • 87 Pages
  • Agrow
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An Overview of RNAi Technology and its Use in New Product Development for Improved Crop Varieties, Crop Protection and Pest Control

FEATURED COMPANIES

  • Alnylam Pharmaceuticals
  • Evogene
  • Ghent University
  • J. R. Simplot
  • Performance Plants
  • Tekmira
  • MORE

Employed as a research tool in entomology and as a means of crop protection and pest control, RNA interference (RNAi) technology is a natural process used to ‘silence’ genes - a way of reducing or switching off the activity (or expression) of individual genes.

With a major drive to tackle resistance to insecticides, RNAi technology has important defence and regulatory functions in animals, plants and fungi. Producing crop hybrids and varieties with enhanced yield and quality characteristics is also a major application of this technology, and superior traits brought to market include improved oil composition (high oleic acid), reduced lignin content (for greater digestibility of feed by livestock), the elimination of browning when slicing apples and potatoes, and reduced potential for acrylamide production when frying potatoes.

This report provides an overview of RNAi technology and its use in new product development for improved crop varieties, crop protection and pest control. It details company and product profiles, and activities and pipelines of specialist companies and research institutes engaged in RNAi technology. It also reviews key safety considerations for the technology, as well as commentary and positions of European and US regulatory authorities.

Other focus areas of this report include research undertaken and commentary about future sprayable RNAi technology, patent applications claiming the use of the technology for disease control, and newer commercial drivers for RNAi applications in crop protection as a possibility of overcoming herbicide resistance in weeds. Increasing crop production in responses to abiotic stress (such as drought) is also considered.

Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Alnylam Pharmaceuticals
  • Evogene
  • Ghent University
  • J. R. Simplot
  • Performance Plants
  • Tekmira
  • MORE

Executive Summary

1. Introduction
1.1 Summary
1.2 Introduction
1.3 Scope
1.4 Technical background
1.4.1 History
1.4.2 Science of RNAi
1.4.2.1 The flow of information in the cell: from DNA to protein via mRNA
1.4.2.2 Discovery of RNA interference
1.4.2.3 Role of RNAi in nature
1.4.2.4 The RNAi process and machinery
1.5 Safety and regulations
1.5.1 Safety
1.5.1.1 Environment
1.5.1.2 Food and feed
1.5.1.3 Non-target organisms
1.5.2 Regulations
1.5.2.1 Europe
1.5.2.2 USA
1.6 References and resources

2. RNAi for controlling insects and other pests
2.1 Summary
2.2 Introduction
2.2.1 Role of RNAi technology
2.2.2 Progress in using RNAi technology
2.3 Coleoptera
2.4 Lepidoptera
2.5 Diptera
2.6 Hemiptera
2.7 Nematodes
2.8 Other pests
2.8.1 Fire ants
2.8.2 Spider mites
2.8.3 Mites
2.8.4 Locusts
2.8.5 Termites
2.9 Patent applications
2.9.1 Insects
2.9.2 Nematodes
2.10 References and resources

3. RNAi in other crop sectors
3.1 Summary
3.2 Introduction
3.3 Control of diseases
3.3.1 Viruses
3.3.2 Progress with RNAi for disease control
3.3.3 Disease control patent applications
3.4 Control of weeds
3.4.1 Overcoming herbicide resistance
3.4.2 Control of parasitic weeds by RNAi
3.5 Crop enhancement
3.5.1 Modified oil composition
3.5.2 Reduced lignin
3.5.3 Abiotic stress
3.5.4 Enzymatic browning
3.5.5 Crop Enhancement patent applications
3.6 References and resources

4. Formulation and delivery of RNAi
4.1 Summary
4.2 Introduction
4.3 Principles
4.3.1 Knowledge base from human therapeutics
4.3.2 Progress in crop protection and pest control
4.3.3 Collaborations
4.4 Patent activity
4.5 References and resources

5. Crop protection companies
5.1 Summary
5.2 Introduction
5.3 BASF
5.3.1 Modified starch potatoes
5.3.2 Disease control
5.3.3 Nematode control
5.3.4 Weed control
5.4 Bayer CropScience
5.4.1 Collaborations
5.4.2 Patent applications
5.5 Dow AgroSciences
5.6 DuPont
5.7 Monsanto
5.7.1 Low lignin alfalfa
5.7.2 SmartStax Pro (MON87411)
5.7.3 BioDirect
5.7.4 Rosetta Green acquisition
5.7.5 Preceres and RNAi delivery R&D
5.7.6 Patent applications
5.8 Syngenta
5.8.1 Collaborations
5.8.2 Patent applications
5.9 References and resources

6. Specialist RNAi technology companies and institutes
6.1 Summary
6.2 Introduction
6.3 Alnylam Pharmaceuticals
6.4 Arbutus Biopharma
6.5 CSIRO
6.6 Evogene
6.7 Forage Genetics
6.8 Forrest Innovations
6.9 Fraunhofer Institute for Molecular Biology and Applied Ecology
6.10 Ghent University
6.11 Iden Biotechnology
6.12 Intrexon
6.13 J. R. Simplot
6.14 Okanagan Specialty Fruits
6.15 Nemgenix
6.16 Performance Plants
6.17 PhaseRx
6.18 Preceres
6.19 University of Cambridge
6.20 University of Nebraska
6.21 Tekmira
6.22 Venganza
6.23 References and resources

Appendix: Abbreviations and Glossary

List of Tables:
Table 1: In planta RNAi products that have been reviewed and approved by at least one international regulatory agency
Table 2: Overview of recently published studies on the use of plant-RNAi against different insect pests
Table 3: Recent PCT and US patent applications covering the control of insects and other pests (excluding those of the crop protection majors)
Table 4: Recent PCT and US patent applications covering the control of nematodes (excluding the crop protection majors)
Table 5: Some recent PCT patent applications covering the control of diseases (excluding the crop protection majors)
Table 6: Recent patent applications covering crop enhancement (excluding the crop protection majors)
Table 7: Recent PCT and US patent applications claiming improved delivery of RNA
Table 8: Recent BASF PCT patents covering RNAi for disease control
Table 9: Recent BASF PCT patents covering RNAi for nematode control
Table 10: Bayer CropScience RNAi PCT patent applications
Table 11: Recent Dow AgroSciences patent applications covering RNAi: Non-collaborative patents
Table 12: Recent Dow AgroSciences patent applications covering RNAi: Patents with the University of Nebraska
Table 13: Recent Dow AgroSciences patent applications covering RNAi: Patents with the Fraunhofer Institute for Molecular Biology and Applied Ecology (Germany)
Table 14: Recent DuPont patent applications covering RNAi
Table 15: Recent Monsanto PCT and US patent applications: Insect and nematode control
Table 16: Recent Monsanto US patent applications: Disease control
Table 17: Recent Monsanto PCT and US patent applications: Crop enhancement
Table 18: Recent Monsanto PCT and US patent applications: Weed control
Table 19: Recent Monsanto PCT and US patent applications: General technology
Table 20: Recent Syngenta PCT patent applications covering RNAi "

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  • Alnylam Pharmaceuticals
  • Arbutus Biopharma
  • CSIRO
  • Evogene
  • Forage Genetics
  • Forrest Innovations
  • Fraunhofer Institute for Molecular Biology and Applied Ecology
  • Ghent University
  • Iden Biotechnology
  • Intrexon
  • J. R. Simplot
  • Nemgenix
  • Okanagan Specialty Fruits
  • Performance Plants
  • PhaseRx
  • Preceres
  • Tekmira
  • University of Cambridge
  • University of Nebraska
  • Venganza
Note: Product cover images may vary from those shown
5 of 4
Note: Product cover images may vary from those shown
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