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Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology

  • ID: 4335181
  • Book
  • November 2017
  • 696 Pages
  • Elsevier Science and Technology
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Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed.

This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized.

  • Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products
  • Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years
  • Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

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1. Fabrication of polymeric core-shell nanostructures 2. Emulsification-diffusion method to obtain polymeric nanoparticles: two decades of research 3. Tools and Techniques for the optimized synthesis, reproducibility and scale up of desired nanostructures from plant derived material and their role in pharmaceutical properties 4. Scale up of biopharmaceuticals production 5. Physicochemical and morphological characterization of pharmaceutical nanocarriers and mathematical modelling of drug encapsulation/release mass transfer processes 6. Biopharmaceutics and pharmacokinetics of multifunctional nanoparticles 7. Technological delivery systems to improve biopharmaceutical properties 8. From physicochemically stable nanocarriers to targeted drug delivery: in-vivo pharmacokinetic, pharmacodynamic and biodistribution studies 9. Sterile dosage forms loaded nanosystems for parenteral, nasal, pulmonary and ocular administration 10. Quantitative Characterization of Targeted Nanoparticulate Formulations for Prediction of Clinical Efficacy 11. Analytical tools for reliable in vitro and in vivo performance testing of drug nanocrystals 12. Application of one-step affinity purification of drug-binding proteins with practical magnetic nanoparticles to drug discovery 13. Molecularly Imprinted Polymers as Separation Tools 14. Detection of DNA damage induced by nanomaterials 15. Pharmacological usage of an enzyme inhibitor
a selective inhibitor of 3-mercaptopyruvate sulfurtransferase reaction intermediate to control generation of polysulfide 16. Regulatory Consideration in Nanotechnology Based Drug Products

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Grumezescu, Alexandru Mihai
Dr. Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biomaterials, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, and Biomaterials and Tissue Engineering Bulletin. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 6 co-authored books and 11 edited books.
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