Sjögren's Syndrome Therapeutics Pipeline Analysis, 2017 - Clinical Trials & Results, Patent, Designation, Collaboration and Other Developments

  • ID: 4340302
  • Report
  • 106 pages
  • P&S Market Research
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Pipeline Overview

Sjögren’s syndrome is a chronic, autoimmune disease identified by lymphocytic infiltration of exocrine glands and epithelia, which leads to sicca symptoms of dry eyes and dry mouth, and objective evidence of keratoconjunctivitis sicca and xerostomia. Sjogren’s syndrome can be present as primary Sjogren’s syndrome, as itself, or as secondary Sogren’s syndrome, in association with underlying immune conditions. Clinical presentation can vary considerably from relatively mild sicca symptoms, fatigue and arthralgia to severe systemic symptoms such as glomerulonephritis, vasculitis and a host of neurological manifestations.

Primary Sjögren’s syndrome is the most common syndrome that varies within the same geographical area and has a strong female propensity. Studies show that the female to male ratio in primary Sjögren’s syndrome varies from as high as 20:1 to 9:1. Caucasian are more prone to the primary Sjögren’s syndrome with mean age of around 40 years. The annual incidence of primary Sjogren’s syndrome was 3.9 per 100,000 persons in year 2002 with higher prevalence in women as compared to men.

As studied by Fox and colleagues, Sjögren’s syndrome mostly occurs due to environmental factors, either viral or non-viral. Sjögren’s syndrome can also occur due to production of cytokine that regulates chemokines with subsequent homing of autoimmune lymphocytes and dendritic cells into the glands via high endothelial venules that express increased levels of cell adhesive molecules. The upregulation of major histocompatibility antigens and adhesive molecules on epithelial cells in the lacrimal and salivary glands leads to the activation of autoantibodies. The secretion of injured lacrimal and salivary gland decrease and resistance of T-cells within glands undergo apoptosis. The infiltrated T cells, B cells and dendritic cells cause destruction of glandular elements by cell mediated mechanisms.

Treatment algorithms are often complicated, with the present treatments for Sjögren’s syndrome including, but not limited to, anti- B-cell-activating factor (BAF), B lymphocyte stimulation (BLyS) inhibitors, bruton’s tyrosine kinase (BTK) inhibitors, endogenous B7 molecules inhibitor and cathepsin S antagonist.

Pipeline Analysis

As of March 2017, the Sjögren’s syndrome pipeline comprises of approximately 42 drug candidates in different stages of development.

Competitive Landscape

Some of the key players developing drugs for Sjögren’s syndrome include Kissei Pharmaceutical Co., Ltd., UCB Group, Bristol-Myers Squibb Company and others.

Scope for Customization

Customization is offered as per specific business requirements of clients. Illustrative customization within the scope of this report includes:
  • Market Forecast - Market analysis and forecast for the drug candidates in the last stage of development
  • Epidemiology Forecast - Epidemiology analysis and forecast.
  • Company Profiles - Wider company coverage in terms of detailed analysis or additional company profiles
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1. Research Background
1.1 Research Objectives
1.2 Definition
1.3 Research Scope
1.4 Key Stakeholders

2. Research Methodology
2.1 Secondary Research
2.2 Primary Research

3. Executive Summary

4. Pipeline Outlook
4.1 Overview
4.2 Key Drivers
4.3 Key Barriers
4.4 Sjögren’S Syndrome Pipeline Analysis
4.4.1 Pipeline Analysis By Phase
4.4.2 Pipeline Analysis By Molecule Type
4.4.3 Pipeline Analysis By Route Of Administration
4.4.4 Pipeline Analysis By Company

5. Sjögren’S Syndrome Therapeutics Pipeline Analysis By Phase (2017)
5.1 Phase Iii: Drug Profiles
5.1.1 Pre-Clinical Study
5.1.2 Pre-Clinical Results
5.1.3 Clinical Trials
5.1.4 Clinical Results
5.1.5 Strategic Development
5.1.6 Designation
5.1.7 Grants
5.1.8 Patent
5.1.9 Technology
5.2 Phase Ii: Drug Profiles
5.2.1 Pre-Clinical Study
5.2.2 Pre-Clinical Results
5.2.3 Clinical Trials
5.2.4 Clinical Results
5.2.5 Strategic Development
5.2.6 Designation
5.2.7 Grants
5.2.8 Patent
5.2.9 Technology
5.3 Phase I: Drug Profiles
5.3.1 Pre-Clinical Study
5.3.2 Pre-Clinical Results
5.3.3 Clinical Trials
5.3.4 Clinical Results
5.3.5 Strategic Development
5.3.6 Designation
5.3.7 Grants
5.3.8 Patent
5.3.9 Technology
5.4 Pre-Clinical: Drug Profiles
5.4.1 Pre-Clinical Study
5.4.2 Pre-Clinical Results
5.4.3 Strategic Development
5.4.4 Designation
5.4.5 Grants
5.4.6 Patent
5.4.7 Technology
5.5 Discontinued: Drug Profiles
5.5.1 Pre-Clinical Study
5.5.2 Pre-Clinical Results
5.5.3 Clinical Trials
5.5.4 Clinical Results
5.5.5 Strategic Development
5.5.6 Designation
5.5.7 Grants
5.5.8 Patent
5.5.9 Technology
5.5 Inactive: Drug Candidates

6 Competitive Landscape
6.1 Key Players Benchmarking For Sjögren’S Syndrome Therapeutic Candidates
6.2 Swot Analysis Of Sjögren’S Syndrome Therapeutics Pipeline

7 Company Profiles
7.1 Business Overview
7.2 Product And Service Offerings

8 Appendix
8.1 Abbreviations

List Of Tables
Pipeline Analysis Of Sjögren’S Syndrome, By Company (2017)
Description Of Phase Iii Drug Candidates
Clinical Trials Of Phase Iii Drug Candidates
Description Of Phase Ii Drug Candidates
Clinical Trials Of Phase Ii Drug Candidates
Description Of Phase I Drug Candidates
Clinical Trials Of Phase I Drug Candidates
Description Of Pre-Clinical Drug Candidates
Description Of Discontinued Drug Candidates
Clinical Trials Of Discontinued Drug Candidates
Inactive Drug Candidates
Companies- At A Glance

List Of Figures
Research Methodology For The Sjögren’S Syndrome Therapeutics Pipeline Analysis
Split Of Primary And Secondary Research
Breakdown Of Primary Research Respondents, By Industry Participant
Breakdown Of Primary Research Respondents, By Company Type
Number Of Sjögren’S Syndrome Drug Candidates Under Development (2017)
Sjögren’S Syndrome Pipeline Split, By Molecule Type (2017)
Sjögren’S Syndrome Pipeline Split, By Route Of Administration (2017)
Key Players Benchmarking For Sjögren’S Syndrome Drug Candidates
Swot Analysis Of Sjögren’S Syndrome Therapeutics Pipeline
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