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Glycogen Synthase Kinase 3 (GSK3) inhibitor - Pipeline Insight, 2022

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    Clinical Trials

  • 60 Pages
  • January 2022
  • Region: Global
  • DelveInsight
  • ID: 5262034
This “Glycogen Synthase Kinase 3 (GSK3) Inhibitor - Pipeline Insight, 2022” report provides comprehensive insights about 8+ companies and 8+ pipeline drugs in Glycogen Synthase Kinase 3 (GSK3) Inhibitor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Understanding

Glycogen Synthase Kinase 3 (GSK3) Inhibitor: Overview


Glycogen synthase kinase 3 (GSK3) is a protein kinase that phosphorylated and inhibited glycogen synthase, the enzyme that catalyzes the transfer of glucose from UDPG to glycogen. Glycogen-synthase kinase-3 (GSK3) exists in two isoforms, termed α and β, which are generated from distinct genes. GSK3 is active in its basal state and is inhibited upon phosphorylation at Ser9 in GSK-3β and at Ser21 in GSK3α. GSK3 is a multifunctional protein kinase and has a broad range of substrates including signaling and structural proteins, as well as transcription factors. It is involved in various key biological processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular transport, gene transcription, proliferation, and intracellular communication. Accordingly, GSK-3 has been implicated in a wide variety of diseases and therefore specifically targeted for both therapeutic and imaging applications.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Glycogen Synthase Kinase 3 (GSK3) Inhibitor R&D. The therapies under development are focused on novel approaches for Glycogen Synthase Kinase 3 (GSK3) Inhibitor.

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Emerging Drugs Chapters


This segment of the Glycogen Synthase Kinase 3 (GSK3) Inhibitor report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Emerging Drugs

Tideglusib: AMO Pharma

Tideglusib is an orally available, small-molecule drug of the thiadiazolidinone class. It acts as an inhibitor of glycogen synthase kinase 3 (GSK3-β), a widely studied tau kinase. Tideglusib is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. The drug is currently under clinical investigation for the treatment of congenital myotonic dystrophy and progressive supranuclear palsy.

9 ING 41: Actuate Therapeutics

9-ING-41 is a first-in-class, intravenously administered, maleimide-based small molecule potent selective GSK-3β inhibitor with significant pre-clinical antitumor activity. 9-ING-41 has significant in vitro and in vivo activity as a single agent and/or in combination with standard cytotoxic chemotherapies in a spectrum of solid tumors and hematological malignancies including bladder, breast, glioblastoma, neuroblastoma, pancreatic, sarcomas, and renal cancers as well as lymphomas. 9-ING-41 is more selective for GSK-3β than for other 320 related kinases when tested in a kinase screen.

Glycogen Synthase Kinase 3 (GSK3) Inhibitor: Therapeutic Assessment


This segment of the report provides insights about the different Glycogen Synthase Kinase 3 (GSK3) Inhibitor drugs segregated based on following parameters that define the scope of the report.

Major Players working on Glycogen Synthase Kinase 3 (GSK3) Inhibitor


There are approx. 8+ key companies which are developing the Glycogen Synthase Kinase 3 (GSK3) Inhibitor. The companies which have their Glycogen Synthase Kinase 3 (GSK3) Inhibitor drug candidates in the most advanced stage, i.e. Phase III include, AMO Pharma.

Phases


This report covers around 8+ products under different phases of clinical development like

  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

Glycogen Synthase Kinase 3 (GSK3) Inhibitor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type

The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Glycogen Synthase Kinase 3 (GSK3) Inhibitor: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Glycogen Synthase Kinase 3 (GSK3) Inhibitor therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Glycogen Synthase Kinase 3 (GSK3) Inhibitor drugs.

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Report Insights

  • Glycogen Synthase Kinase 3 (GSK3) Inhibitor Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions


Current Scenario and Emerging Therapies:

  • How many companies are developing Glycogen Synthase Kinase 3 (GSK3) Inhibitor drugs?
  • How many Glycogen Synthase Kinase 3 (GSK3) Inhibitor drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Glycogen Synthase Kinase 3 (GSK3) Inhibitor?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Glycogen Synthase Kinase 3 (GSK3) Inhibitor therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Glycogen Synthase Kinase 3 (GSK3) Inhibitor and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • AMO Pharma
  • Actuate Therapeutics
  • Rock Creek Pharmaceuticals
  • BCN Biosciences
  • HitGen

Key Products

  • Tideglusib
  • 9 ING 41
  • Anatabine
  • BCN-057

Research program: glycogen synthase kinase 3 beta inhibitors

Table of Contents

Introduction

Executive Summary

Glycogen Synthase Kinase 3 (GSK3) Inhibitor: Overview
  • Structure
  • Mechanism of Action

Pipeline Therapeutics
  • Comparative Analysis

Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Glycogen Synthase Kinase 3 (GSK3) Inhibitor - Analytical Perspective

In-depth Commercial Assessment
  • Glycogen Synthase Kinase 3 (GSK3) Inhibitor companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Phase III)
  • Comparative Analysis

Tideglusib: AMO Pharma
  • Product Description
  • Research and Development
  • Product Development Activities

Mid Stage Products (Phase II)
  • Comparative Analysis

9 ING 41: Actuate Therapeutics
  • Product Description
  • Research and Development
  • Product Development Activities

Early Stage Products (Phase I)
  • Comparative Analysis

Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities

Pre-clinical and Discovery Stage Products
  • Comparative Analysis

BCN-057 BCN Biosciences
  • Product Description
  • Research and Development
  • Product Development Activities

Inactive Products
  • Comparative Analysis

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Key Companies

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Key Products

Glycogen Synthase Kinase 3 (GSK3) Inhibitor- Unmet Needs

Glycogen Synthase Kinase 3 (GSK3) Inhibitor- Market Drivers and Barriers

Glycogen Synthase Kinase 3 (GSK3) Inhibitor- Future Perspectives and Conclusion

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Analyst Views

Glycogen Synthase Kinase 3 (GSK3) Inhibitor Key Companies

AppendixList of Tables
Table 1 Total Products for Glycogen Synthase Kinase 3 (GSK3) Inhibitor
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive ProductsList of Figures
Figure 1 Total Products for Glycogen Synthase Kinase 3 (GSK3) Inhibitor
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • AMO Pharma
  • Actuate Therapeutics
  • Rock Creek Pharmaceuticals
  • BCN Biosciences
  • HitGen