Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students.
- Combines both the methods of study for human aging and animal models
- Provides a historical overview and discussion of model availability, key methods and ethical issues
- Contains over 200 full color illustrations
I. Aging in Humans 1. Werner Syndrome as a model of human aging 2. Premature aging syndrome 3. Models, Definitions, and Criteria of Frailty 4. Immunological methods and the concept of inflamm-aging in the study of human aging 5. Vulnerability and Experiential Health in Old Age
a qualitative perspective 6. Body composition analysis in older adults 7. Using Computational Models to Study Aging 8. A framework for uncovering the roles of calories and macronutrients in health and aging 9. Female Reproductive Aging: From Consequences to Mechanisms, Markers, and Treatments 10. Adrenopause 11. What sets Iceland apart in understanding human aging
II. Animal models: Vertebrates 12. Reproductive Tract Lesions in Aged Chimpanzees 13. Age-related changes to the bony structure and musculature of the shoulder in a nonhuman primate model 14. The dog as a model for aging research 15. Dogs as a Spontaneous Model for Early Alzheimer's Disease 16. Determining cause of death and contributing causes of death in rodent aging studies 17. Rat Models of Cognitive Aging 18. Life Extension in Dwarf Mice 19. Extension of Lifespan in Laboratory Mice 20. Development and Validation of ECG analysis algorithm in mice 21. Old mouse lemur: behavior, cognition and neuropathology 22. Birds as models for the biology of aging and aging-related disease: an update 23. Telomeres and Telomerase in Birds: Measuring Health, Environmental Stress and Longevity 24. Zebrafish model for investigating the integrated control of reproduction 25. Modelling aging and age-associated pathology in zebrafish 26. The use of mature zebrafish (Danio rerio) as a model for human aging and disease 27. Piscine polemics; Small tropical fish species as models for aging research 28. The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on aging
III. Cellular models and invertebrates 29. A Budding Topic: Modeling Aging and Longevity in Yeast 30. The Budding and Fission Yeast Model Systems for Aging Biology: Rapid Advancement with New Technologies 31. Podospora anserina: a filamentous fungus with a strong mitochondrial etiology of aging 32. Invertebrates as model organisms for research on aging biology 33. Invertebrate models for the study of the effects of age on neurotransmitter release 34. Impact of Chronic Exercise on Invertebrate Functional Aging 35. The virtues and challenges of multidimensional analyses of whole brains during aging with single cell resolution 36. Rotifers as a Model for the Biology of Aging 37. The Potential of Comparative Biology to Reveal Mechanisms of Aging in Rotifers 38. Hydra, a model system for deciphering the mechanisms of aging and resistance to aging 39. Regeneration and Aging in The Tunicate Ciona intestinalis 40. Honeybee Workers as Models of Aging
IV. Disease models 41. Approaches to the Assessment of Frailty in Animal Models 42. Genotype and sex differences in life expectancy in transgenic AD mice 43. Animal models of vascular cognitive impairment and dementia 44. Alzheimer's Dementia Drug Discovery: Targeting Synaptic Glutamate Uptake 45. A Transgenic Monkey Model of Huntington's Disease 46. Parkinson's Disease in Humans and in Non-Human Primate Aging and Neurotoxin Models 47. Genetic Models of Parkinson's Disease and Their Study in Non-Human Primates 48. Impact of the Aged Brain Environment on Gene Therapy for Parkinson's Disease 49. Cell Therapy for Parkinson's Disease 50. Genetics of progeria and aging 51. Progeria mouse models 52. Models of Hypertension in Aging 53. Osteoporosis and Cardiovascular Disease in the Elderly 54. The role of the tumor microenvironment in pancreatic ductal adenocarcinoma and preclinical models to study it
V. Organ systems 55. Alopecia 56. Experimental Models of human skin aging 57. Muscle deconditioning and aging: experimental models 58. Models of Immune Aging 59. Sex and the aging immune system 60. Rodent Models of Ovarian Failure 61. Role of Sex and Aging in Mucosal Health 62. Leydig Cell Development and Aging in the Brown Norway Rat: Mechanisms and Consequences 63. Models of aging Kidney: Implications on kidney health and disease 64. Age-Associated Changes in Structure and Function of the Aging Human Lung 65. Glucose, insulin and brain aging 66. Pathology of brain aging and animal models of neurodegenerative diseases 67. Leptin and aging in animal models 68. Age-Related Changes to Bone Structure and Quality in Rodent Models
VI. Mechanisms 69. Dielectric properties of biological tissues; variation with age 70. Experimental Models of Tau Aggregation 71. Aging of Human Mesenchymal Stem Cells 72. Helicases and their relevance to aging 73. Genetics of human aging 74. Epigenetics of brain Aging 75. The Circadian Clock and the Aging Process 76. Super DNAging-New insights into DNA integrity, genome stability and telomeres in the oldest old 77. Model of Chaperones in Aging 78. Chaperone-mediated autophagy 79. Resveratrol in Aging and Age-Related Diseases 80. Resveratrol in experimental models and humans
Jeffrey L. Ram is Professor of Physiology at the Wayne State University School of Medicine and the Director of the Belle Isle Aquarium Laboratory in Detroit, MI USA. After receiving a B.A. Magna cum Laude degree in Physics from the University of Pennsylvania (1967) and being a Thouron Scholar at Cambridge University (1967-1968), he earned a Ph.D. degree in Biochemistry and Neurophysiology from the California Institute of Technology (1974). Following post-doctoral research at the University of California Santa Cruz, and a fellowship at the Marine Biological Laboratory in Woods Hole, MA USA, he joined the faculty in the Department of Physiology of Wayne State University in 1977. Ram is known for his studies of the endocrine, neural, and pharmacological control of reproduction, muscle, and digestive physiology in invertebrate model systems, especially Aplysia, his research on invasive mussels, and recent studies on aquatic biodiversity. Together with Dr. Mahadev Murthy (NIH) he developed symposia and publications on the use of model systems for the study of aging, an activity that he has continued as President of the International Society for Invertebrate Reproduction and Development (2014 - 2017). Ram's collaborations on vertebrate systems have included biodiversity studies of the fecal and oral microbiome of animals and people. He has authored or co-authored over 150 publications in these areas and edited the proceedings of several symposia, including a 10 paper issue on model systems for the study of aging for the Journal of Invertebrate Reproduction and Development. The work of his laboratory has been recognized by numerous grants from NIH, NSF, EPA, and various foundations such as the American Heart Association and the Myasthenia Gravis Foundation. Ram is an elected fellow of the American Association for the Advancement of Science. As head of an NSF project to promote the interest of public school students in science and science careers, Ram works closely with the Belle Isle Aquarium and the Detroit Public Schools Community District to increase the public understanding of how scientists work and the importance and place of science in protecting the environment.
Conn, P. Michael
P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public's awareness of diabetes. Conn's students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.