Gastric and Esophageal Cancer Drug Development Pipeline Review, 2017

  • ID: 4434630
  • Report
  • 244 pages
  • GBI Research
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Gastric cancer, also called stomach cancer, is a malignant tumor arising from the lining of the stomach. Signs and symptoms of gastric cancer include fatigue, stomach pain, vomiting, weight loss that is unintentional, feeling bloated after eating, heartburn and indigestion. There are a total of 322 products in development for this indication, by 208 companies and 22 academic institutions. Key companies operating in this pipeline space include Eli Lilly, Roche, Bristol-Myers Squibb, Incyte, Pfizer and AstraZeneca.

Esophageal cancer is cancer that occurs in the esophagus. Symptoms include cough, difficulty swallowing, chest pain, pressure or burning and weight loss. Predisposing factors include age, smoking, obesity and bile reflux. There are a total of 107 products in development for this indication, by 79 companies and 11 academic institutions.

Key targets in development across both indications include human epidermal growth factors 1 and 2, and programmed cell death protein 1. In addition, the hepatocyte and vascular endothelial growth factors are being developed across many pipeline programs in gastric cancer.

This report provides an overview of the Gastric and Esophageal Cancer pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for each of these cancer types, and features dormant and discontinued projects.

Scope

  • Which companies are the most active within each pipeline?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in this disease area?

Reasons to buy

  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration
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1 Table of Contents
1 Table of Contents
1.1 List of Tables
1.2 List of Figures

2 Introduction
2.1 Gastric and Esophageal Cancer Report Coverage
2.2 Esophageal Cancer – Overview
2.3 Gastric Cancer – Overview

3 Therapeutics Development
3.1 Esophageal Cancer
3.2 Gastric Cancer

4 Therapeutics Assessment
4.1 Esophageal Cancer
4.2 Gastric Cancer

5 Companies Involved in Therapeutics Development
5.1 Esophageal Cancer
5.2 Gastric Cancer

6 Dormant Projects
6.1 Esophageal Cancer
6.2 Gastric Cancer

7 Discontinued Products
7.1 Esophageal Cancer
7.2 Gastric Cancer

8 Product Development Milestones
8.1 Esophageal Cancer
8.2 Gastric Cancer

9 Appendix
9.1 Methodology
9.2 Coverage
9.3 Secondary Research
9.4 Primary Research
9.5 Expert Panel Validation
9.6 Contact Us
9.7 Disclaimer

 List of Tables
Table 1: Number of Products under Development for Esophageal Cancer
Table 2: Number of Products under Development by Companies, Esophageal Cancer
Table 3: Number of Products under Development by Universities/Institutes, Esophageal Cancer
Table 4: Products under Development by Companies, Esophageal Cancer
Table 5: Products under Development by Universities/Institutes, Esophageal Cancer
Table 6: Number of Products under Development for Gastric Cancer
Table 7: Number of Products under Development by Companies, Gastric Cancer
Table 8: Number of Products under Development by Universities/Institutes, Gastric Cancer
Table 9: Products under Development by Companies, Gastric Cancer
Table 10: Products under Development by Universities/Institutes, Gastric Cancer
Table 11: Number of Products by Stage and Target, Esophageal Cancer
Table 12: Number of Products by Stage and Mechanism of Action, Esophageal Cancer
Table 13: Number of Products by Stage and Route of Administration, Esophageal Cancer
Table 14: Number of Products by Stage and Molecule Type, Esophageal Cancer
Table 15: Number of Products by Stage and Target, Gastric Cancer
Table 16: Number of Products by Stage and Mechanism of Action, Gastric Cancer
Table 17: Number of Products by Stage and Route of Administration, Gastric Cancer
Table 18: Number of Products by Stage and Molecule Type, Gastric Cancer
Table 19: Esophageal Cancer – Pipeline by Adaptimmune Therapeutics Plc
Table 20: Esophageal Cancer – Pipeline by ADC Therapeutics Sarl
Table 21: Esophageal Cancer – Pipeline by Aduro BioTech Inc
Table 22: Esophageal Cancer – Pipeline by Advenchen Laboratories LLC
Table 23: Esophageal Cancer – Pipeline by Almac Discovery Ltd
Table 24: Esophageal Cancer – Pipeline by Ambrx Inc
Table 25: Esophageal Cancer – Pipeline by Amgen Inc
Table 26: Esophageal Cancer – Pipeline by Aprea AB
Table 27: Esophageal Cancer – Pipeline by ArQule Inc
Table 28: Esophageal Cancer – Pipeline by Array BioPharma Inc
Table 29: Esophageal Cancer – Pipeline by Aslan Pharmaceuticals Pte Ltd
Table 30: Esophageal Cancer – Pipeline by Bayer AG
Table 31: Esophageal Cancer – Pipeline by BeiGene Ltd
Table 32: Esophageal Cancer – Pipeline by BioStar Pharmaceuticals Inc
Table 33: Esophageal Cancer – Pipeline by Boehringer Ingelheim GmbH
Table 34: Esophageal Cancer – Pipeline by Bristol-Myers Squibb Co
Table 35: Esophageal Cancer – Pipeline by Cascadian Therapeutics Inc
Table 36: Esophageal Cancer – Pipeline by CBT Pharmaceuticals Inc
Table 37: Esophageal Cancer – Pipeline by Celgene Corp
Table 38: Esophageal Cancer – Pipeline by Celldex Therapeutics Inc
Table 39: Esophageal Cancer – Pipeline by Cellectar Biosciences Inc
Table 40: Esophageal Cancer – Pipeline by Clovis Oncology Inc
Table 41: Esophageal Cancer – Pipeline by Cyclacel Pharmaceuticals Inc
Table 42: Esophageal Cancer – Pipeline by DAE HWA Pharmaceutical Co Ltd
Table 43: Esophageal Cancer – Pipeline by Eli Lilly and Co
Table 44: Esophageal Cancer – Pipeline by F. Hoffmann-La Roche Ltd
Table 45: Esophageal Cancer – Pipeline by Genmab A/S
Table 46: Esophageal Cancer – Pipeline by GlaxoSmithKline Plc
Table 47: Esophageal Cancer – Pipeline by Glycotope GmbH
Table 48: Esophageal Cancer – Pipeline by Hanmi Pharmaceuticals Co Ltd
Table 49: Esophageal Cancer – Pipeline by Hutchison MediPharma Ltd
Table 50: Esophageal Cancer – Pipeline by Ignyta Inc
Table 51: Esophageal Cancer – Pipeline by Immunocore Ltd
Table 52: Esophageal Cancer – Pipeline by ImmunoFrontier Inc
Table 53: Esophageal Cancer – Pipeline by Immunomedics Inc
Table 54: Esophageal Cancer – Pipeline by Incyte Corp
Table 55: Esophageal Cancer – Pipeline by Jiangsu Hengrui Medicine Co Ltd
Table 56: Esophageal Cancer – Pipeline by Johnson & Johnson
Table 57: Esophageal Cancer – Pipeline by Leap Therapeutics Inc
Table 58: Esophageal Cancer – Pipeline by Madrigal Pharmaceuticals Inc.
Table 59: Esophageal Cancer – Pipeline by MaxiVAX SA
Table 60: Esophageal Cancer – Pipeline by Mebiopharm Co Ltd
Table 61: Esophageal Cancer – Pipeline by MedImmune LLC
Table 62: Esophageal Cancer – Pipeline by Merck & Co Inc
Table 63: Esophageal Cancer – Pipeline by Merrimack Pharmaceuticals Inc
Table 64: Esophageal Cancer – Pipeline by Novartis AG
Table 65: Esophageal Cancer – Pipeline by Omeros Corp
Table 66: Esophageal Cancer – Pipeline by Omnitura Therapeutics Inc
Table 67: Esophageal Cancer – Pipeline by Oncolys BioPharma Inc
Table 68: Esophageal Cancer – Pipeline by Ono Pharmaceutical Co Ltd
Table 69: Esophageal Cancer – Pipeline by Puma Biotechnology Inc
Table 70: Esophageal Cancer – Pipeline by Rhizen Pharmaceuticals SA
Table 71: Esophageal Cancer – Pipeline by Shionogi & Co Ltd
Table 72: Esophageal Cancer – Pipeline by Spectrum Pharmaceuticals Inc
Table 73: Esophageal Cancer – Pipeline by Steba Biotech SA
Table 74: Esophageal Cancer – Pipeline by Stelic Institute & Co Inc
Table 75: Esophageal Cancer – Pipeline by Supratek Pharma Inc
Table 76: Esophageal Cancer – Pipeline by Symphogen A/S
Table 77: Esophageal Cancer – Pipeline by Taiho Pharmaceutical Co Ltd
Table 78: Esophageal Cancer – Pipeline by Taiwan Liposome Company Ltd
Table 79: Esophageal Cancer – Pipeline by Takara Bio Inc
Table 80: Esophageal Cancer – Pipeline by Transgene Biotek Ltd
Table 81: Esophageal Cancer – Pipeline by XuanZhu Pharma Co Ltd
Table 82: Gastric Cancer – Pipeline by 3SBio Inc
Table 83: Gastric Cancer – Pipeline by AbbVie Inc
Table 84: Gastric Cancer – Pipeline by AbGenomics International Inc
Table 85: Gastric Cancer – Pipeline by Abion Inc
Table 86: Gastric Cancer – Pipeline by Adaptimmune Therapeutics Plc
Table 87: Gastric Cancer – Pipeline by ADC Therapeutics Sarl
Table 88: Gastric Cancer – Pipeline by Aduro BioTech Inc
Table 89: Gastric Cancer – Pipeline by Advenchen Laboratories LLC
Table 90: Gastric Cancer – Pipeline by Allist Shanghai Pharmaceutical Technology Co Ltd
Table 91: Gastric Cancer – Pipeline by Almac Discovery Ltd
Table 92: Gastric Cancer – Pipeline by Alteogen Inc
Table 93: Gastric Cancer – Pipeline by Ambrx Inc
Table 94: Gastric Cancer – Pipeline by amcure GmbH
Table 95: Gastric Cancer – Pipeline by Amgen Inc
Table 96: Gastric Cancer – Pipeline by ANP Technologies Inc
Table 97: Gastric Cancer – Pipeline by Antikor Biopharma Ltd
Table 98: Gastric Cancer – Pipeline by arGEN-X BV
Table 99: Gastric Cancer – Pipeline by Array BioPharma Inc
Table 100: Gastric Cancer – Pipeline by Asana BioSciences LLC
Table 101: Gastric Cancer – Pipeline by Aslan Pharmaceuticals Pte Ltd
Table 102: Gastric Cancer – Pipeline by Astellas Pharma Inc
Table 103: Gastric Cancer – Pipeline by AstraZeneca Plc
Table 104: Gastric Cancer – Pipeline by Athenex Inc
Table 105: Gastric Cancer – Pipeline by Basilea Pharmaceutica Ltd
Table 106: Gastric Cancer – Pipeline by Bayer AG
Table 107: Gastric Cancer – Pipeline by BeiGene Ltd
Table 108: Gastric Cancer – Pipeline by Beijing Hanmi Pharmaceutical Co Ltd
Table 109: Gastric Cancer – Pipeline by Betta Pharmaceuticals Co Ltd
Table 110: Gastric Cancer – Pipeline by Biocon Ltd
Table 111: Gastric Cancer – Pipeline by Bioleaders Corp
Table 112: Gastric Cancer – Pipeline by Bionovis SA
Table 113: Gastric Cancer – Pipeline by Boehringer Ingelheim GmbH
Table 114: Gastric Cancer – Pipeline by Bristol-Myers Squibb Co
Table 115: Gastric Cancer – Pipeline by Camel-IDS NV
Table 116: Gastric Cancer – Pipeline by Cancer Prevention Pharmaceuticals Inc
Table 117: Gastric Cancer – Pipeline by Cascadian Therapeutics Inc
Table 118: Gastric Cancer – Pipeline by CBT Pharmaceuticals Inc
Table 119: Gastric Cancer – Pipeline by Celgene Corp
Table 120: Gastric Cancer – Pipeline by Celldex Therapeutics Inc
Table 121: Gastric Cancer – Pipeline by Cellectar Biosciences Inc
Table 122: Gastric Cancer – Pipeline by Celltrion Inc
Table 123: Gastric Cancer – Pipeline by Celon Pharma SA
Table 124: Gastric Cancer – Pipeline by Chipscreen Biosciences Ltd
Table 125: Gastric Cancer – Pipeline by Chugai Pharmaceutical Co Ltd
Table 126: Gastric Cancer – Pipeline by Curaxys SL
Table 127:  Gastric Cancer – Pipeline by Cytori Therapeutics Inc
Table 128: Gastric Cancer – Pipeline by Daiichi Sankyo Co Ltd
Table 129: Gastric Cancer – Pipeline by Debiopharm International SA
Table 130: Gastric Cancer – Pipeline by Deciphera Pharmaceuticals LLC
Table 131: Gastric Cancer – Pipeline by Dr. Reddy's Laboratories Ltd
Table 132: Gastric Cancer – Pipeline by Eddingpharm Inc
Table 133: Gastric Cancer – Pipeline by Eli Lilly and Co
Table 134: Gastric Cancer – Pipeline by EOS Biosciences Inc
Table 135: Gastric Cancer – Pipeline by Erytech Pharma SA
Table 136: Gastric Cancer – Pipeline by Esperance Pharmaceuticals Inc
Table 137: Gastric Cancer – Pipeline by Exelixis Inc
Table 138: Gastric Cancer – Pipeline by F-star Biotechnology Ltd
Table 139: Gastric Cancer – Pipeline by F. Hoffmann-La Roche Ltd
Table 140: Gastric Cancer – Pipeline by Five Prime Therapeutics Inc
Table 141: Gastric Cancer – Pipeline by Frost Biologic Inc
Table 142: Gastric Cancer – Pipeline by Galena Biopharma Inc
Table 143: Gastric Cancer – Pipeline by Genelux Corp
Table 144: Gastric Cancer – Pipeline by Genentech Inc
Table 145: Gastric Cancer – Pipeline by Gilead Sciences Inc
Table 146: Gastric Cancer – Pipeline by GlaxoSmithKline Plc
Table 147: Gastric Cancer – Pipeline by Glenmark Pharmaceuticals Ltd
Table 148: Gastric Cancer – Pipeline by GlycoNex Inc
Table 149: Gastric Cancer – Pipeline by Glycotope GmbH
Table 150: Gastric Cancer – Pipeline by Green Cross Corp
Table 151: Gastric Cancer – Pipeline by Halozyme Therapeutics Inc
Table 152: Gastric Cancer – Pipeline by Hanmi Pharmaceuticals Co Ltd
Table 153: Gastric Cancer – Pipeline by Horizon Pharma Plc
Table 154: Gastric Cancer – Pipeline by Humanigen Inc
Table 155: Gastric Cancer – Pipeline by Hummingbird Bioscience Pte Ltd
Table 156: Gastric Cancer – Pipeline by Hutchison MediPharma Ltd
Table 157: Gastric Cancer – Pipeline by Ignyta Inc
Table 158: Gastric Cancer – Pipeline by Ildong Pharmaceutical Co Ltd
Table 159: Gastric Cancer – Pipeline by Immunomedics Inc
Table 160: Gastric Cancer – Pipeline by Incyte Corp
Table 161: Gastric Cancer – Pipeline by Inovio Pharmaceuticals Inc
Table 162: Gastric Cancer – Pipeline by Inspyr Therapeutics Inc
Table 163: Gastric Cancer – Pipeline by Insys Therapeutics Inc
Table 164: Gastric Cancer – Pipeline by Ipsen SA
Table 165: Gastric Cancer – Pipeline by Jiangsu Hengrui Medicine Co Ltd
Table 166: Gastric Cancer – Pipeline by Jiangsu Kanion Pharmaceutical Co Ltd
Table 167: Gastric Cancer – Pipeline by Johnson & Johnson
Table 168: Gastric Cancer – Pipeline by Jounce Therapeutics Inc
Table 169: Gastric Cancer – Pipeline by Konruns Pharmaceutical Co Ltd
Table 170: Gastric Cancer – Pipeline by Kringle Pharma Inc
Table 171: Gastric Cancer – Pipeline by Kuhnil Pharmaceutical Co Ltd
Table 172: Gastric Cancer – Pipeline by Kyowa Hakko Kirin Co Ltd
Table 173: Gastric Cancer – Pipeline by LATITUDE Pharmaceuticals Inc
Table 174: Gastric Cancer – Pipeline by LegoChem Biosciences Inc
Table 175: Gastric Cancer – Pipeline by LinXis BV
Table 176: Gastric Cancer – Pipeline by MacroGenics Inc
Table 177: Gastric Cancer – Pipeline by Madrigal Pharmaceuticals Inc.
Table 178: Gastric Cancer – Pipeline by MaxiVAX SA
Table 179: Gastric Cancer – Pipeline by Mebiopharm Co Ltd
Table 180: Gastric Cancer – Pipeline by MedImmune LLC
Table 181: Gastric Cancer – Pipeline by Merck & Co Inc
Table 182: Gastric Cancer – Pipeline by Merck KGaA
Table 183: Gastric Cancer – Pipeline by Merrimack Pharmaceuticals Inc
Table 184: Gastric Cancer – Pipeline by Mersana Therapeutics Inc
Table 185: Gastric Cancer – Pipeline by Merus NV
Table 186: Gastric Cancer – Pipeline by Mirati Therapeutics Inc
Table 187: Gastric Cancer – Pipeline by Molecular Partners AG
Table 188: Gastric Cancer – Pipeline by Molecular Targeting Technologies Inc
Table 189: Gastric Cancer – Pipeline by Moleculin Biotech Inc
Table 190: Gastric Cancer – Pipeline by MolMed SpA
Table 191: Gastric Cancer – Pipeline by NanoCarrier Co Ltd
Table 192:  Gastric Cancer – Pipeline by Novartis AG
Table 193: Gastric Cancer – Pipeline by Novogen Ltd
Table 194: Gastric Cancer – Pipeline by OBI Pharma Inc
Table 195: Gastric Cancer – Pipeline by Oncobiologics Inc
Table 196: Gastric Cancer – Pipeline by Oncolys BioPharma Inc
Table 197: Gastric Cancer – Pipeline by OncoMed Pharmaceuticals Inc
Table 198: Gastric Cancer – Pipeline by OncoResponse Inc
Table 199: Gastric Cancer – Pipeline by Ono Pharmaceutical Co Ltd
Table 200: Gastric Cancer – Pipeline by Opsona Therapeutics Ltd
Table 201: Gastric Cancer – Pipeline by Patrys Ltd
Table 202: Gastric Cancer – Pipeline by Pfizer Inc
Table 203: Gastric Cancer – Pipeline by Pharma Mar SA
Table 204: Gastric Cancer – Pipeline by Pieris Pharmaceuticals Inc
Table 205: Gastric Cancer – Pipeline by Plexxikon Inc
Table 206: Gastric Cancer – Pipeline by Prescient Therapeutics Ltd
Table 207: Gastric Cancer – Pipeline by Puma Biotechnology Inc
Table 208: Gastric Cancer – Pipeline by Redx Pharma Plc
Table 209: Gastric Cancer – Pipeline by Rhizen Pharmaceuticals SA
Table 210: Gastric Cancer – Pipeline by Richter Gedeon Nyrt
Table 211: Gastric Cancer – Pipeline by Samumed LLC
Table 212: Gastric Cancer – Pipeline by Sanofi
Table 213: Gastric Cancer – Pipeline by Selecta Biosciences Inc
Table 214: Gastric Cancer – Pipeline by Sequella Inc
Table 215: Gastric Cancer – Pipeline by Shionogi & Co Ltd
Table 216: Gastric Cancer – Pipeline by Simcere Pharmaceutical Group
Table 217: Gastric Cancer – Pipeline by Sorrento Therapeutics Inc
Table 218: Gastric Cancer – Pipeline by Spectrum Pharmaceuticals Inc
Table 219: Gastric Cancer – Pipeline by Stelic Institute & Co Inc
Table 220: Gastric Cancer – Pipeline by Supratek Pharma Inc
Table 221: Gastric Cancer – Pipeline by SynCore Biotechnology Co Ltd
Table 222: Gastric Cancer – Pipeline by Synovo GmbH
Table 223: Gastric Cancer – Pipeline by Synthon Holdings BV
Table 224: Gastric Cancer – Pipeline by Taiho Pharmaceutical Co Ltd
Table 225: Gastric Cancer – Pipeline by Taiwan Liposome Company Ltd
Table 226: Gastric Cancer – Pipeline by Takis Srl
Table 227: Gastric Cancer – Pipeline by Tessa Therapeutics Pte Ltd
Table 228:  Gastric Cancer – Pipeline by Transgene SA
Table 229: Gastric Cancer – Pipeline by Tyrogenex Inc
Table 230: Gastric Cancer – Pipeline by United BioPharma Inc
Table 231: Gastric Cancer – Pipeline by Vaxon Biotech
Table 232: Gastric Cancer – Pipeline by ViiV Healthcare Ltd
Table 233: Gastric Cancer – Pipeline by Viracta Therapeutics Inc
Table 234: Gastric Cancer – Pipeline by XuanZhu Pharma Co Ltd
Table 235: Gastric Cancer – Pipeline by Zymeworks Inc
Table 236: Esophageal Cancer – Dormant Projects
Table 237: Gastric Cancer – Dormant Projects
Table 238: Esophageal Cancer – Discontinued Products
Table 239: Gastric Cancer – Discontinued Products

List of Figures
Figure 1: Number of Products under Development for Esophageal Cancer
Figure 2: Number of Products under Development by Companies, Esophageal Cancer
Figure 3: Number of Products under Development by Universities/Institutes, Esophageal Cancer
Figure 4: Number of Products under Development for Gastric Cancer
Figure 5: Number of Products under Development by Companies, Gastric Cancer
Figure 6: Number of Products under Development by Universities/Institutes, Gastric Cancer
Figure 7: Number of Products by Top 10 Targets, Esophageal Cancer
Figure 8: Number of Products by Stage and Top 10 Targets, Esophageal Cancer
Figure 9: Number of Products by Top 10 Mechanism of Actions, Esophageal Cancer
Figure 10: Number of Products by Stage and Top 10 Mechanism of Actions, Esophageal Cancer
Figure 11: Number of Products by Top 10 Routes of Administration, Esophageal Cancer
Figure 12: Number of Products by Stage and Top 10 Routes of Administration, Esophageal Cancer
Figure 13: Number of Products by Top 10 Molecule Types, Esophageal Cancer
Figure 14: Number of Products by Stage and Top 10 Molecule Types, Esophageal Cancer
Figure 15: Number of Products by Top 10 Targets, Gastric Cancer
Figure 16: Number of Products by Stage and Top 10 Targets, Gastric Cancer
Figure 17: Number of Products by Top 10 Mechanism of Actions, Gastric Cancer
Figure 18: Number of Products by Stage and Top 10 Mechanism of Actions, Gastric Cancer
Figure 19: Number of Products by Routes of Administration, Gastric Cancer
Figure 20: Number of Products by Stage and Routes of Administration, Gastric Cancer
Figure 21: Number of Products by Top 10 Molecule Types, Gastric Cancer
Figure 22: Number of Products by Stage and Top 10 Molecule Types, Gastric Cancer

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