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Summary
According to the recently published report 'Leukocyte Surface Antigen CD47 - Pipeline Review, H2 2019'; Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) pipeline Target constitutes close to 53 molecules. Out of which approximately 51 molecules are developed by companies and remaining by the universities/institutes.
Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) - CD47 (Cluster of Differentiation 47) or integrin associated protein (IAP) is a transmembrane protein encoded by the CD47 gene. It has a role in both cell adhesions by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). It acts as a receptor for SIRPA. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and co-stimulates T-cell activation. It plays an important role in membrane transport and/or integrin dependent signal transduction. It prevents premature elimination of red blood cells.
The report 'Leukocyte Surface Antigen CD47 - Pipeline Review, H2 2019' outlays comprehensive information on the Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 1, 2, 10, 1, 28 and 9 respectively. Similarly, the universities portfolio in Preclinical stages comprises 2 molecules, respectively. Report covers products from therapy areas Oncology, Infectious Disease and Metabolic Disorders which include indications Solid Tumor, Diffuse Large B-Cell Lymphoma, Lymphoma, Non-Hodgkin Lymphoma, Refractory Multiple Myeloma, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Breast Cancer, Colorectal Cancer, Myelodysplastic Syndrome, Non-Small Cell Lung Cancer, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Relapsed Multiple Myeloma, Glioblastoma Multiforme (GBM), Ovarian Cancer, Pancreatic Cancer, Peritoneal Cancer, Small-Cell Lung Cancer, B-Cell Non-Hodgkin Lymphoma, Blood Cancer, Cutaneous T-Cell Lymphoma, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Follicular Lymphoma, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Leukemia, Marginal Zone B-cell Lymphoma, Melanoma, Refractory Chronic Lymphocytic Leukemia (CLL), Relapsed Chronic Lymphocytic Leukemia (CLL), Triple-Negative Breast Cancer (TNBC), Bladder Cancer, Cerebral (Fatal) Malaria, Chronic Lymphocytic Leukemia (CLL), Colon Carcinoma, Diabetic Retinopathy, Gastric Cancer, Gastroesophageal (GE) Junction Carcinomas, Gastrointestinal Tract Cancer, Gliosarcoma, Head And Neck Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Hematological Tumor, High-Grade Glioma, Leiomyosarcoma, Lung Cancer, Mantle Cell Lymphoma, Metastatic Brain Tumor, Metastatic Breast Cancer, Metastatic Colorectal Cancer, Metastatic Melanoma, Metastatic Transitional (Urothelial) Tract Cancer, Mycosis Fungoides, Myeloproliferative Disorders, Neuroendocrine Tumors, Non-Small Cell Lung Carcinoma, Oral Cavity (Mouth) Cancer, Oropharyngeal Cancer, Peripheral T-Cell Lymphomas (PTCL), Sezary Syndrome, Thymic Carcinoma and Transitional Cell Cancer (Urothelial Cell Cancer).
Scope
- The report provides a snapshot of the global therapeutic landscape for Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47)
- The report reviews Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) targeted therapeutics and enlists all their major and minor projects
- The report assesses Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) targeted therapeutics
Reasons to buy
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
IntroductionReport Coverage
Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) - Overview
Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) - Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) - Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) - Companies Involved in Therapeutics Development
Abpro Corp
ALX Oncology Inc
Arch Oncology Inc
Aurigene Discovery Technologies Ltd
Beijing Hanmi Pharmaceutical Co Ltd
Biocad
Bristol-Myers Squibb Co
EpicentRx Inc
Forty Seven Inc
GeneScience Pharmaceuticals Co Ltd
GigaGen Inc
Hummingbird Bioscience Pte Ltd
I-Mab Biopharma Co Ltd
ImmuneOncia Therapeutics LLC
ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd
Innovent Biologics Inc
Jiangsu Hengrui Medicine Co Ltd
KAHR medical Ltd
LynkCell Inc
MesaGen LLC
NovImmune SA
Opsyon
Paradigm Shift Therapeutics LLC
Phanes Therapeutics Inc
PharmAbcine Inc
Shanghai Henlius Biotech Inc
Sorrento Therapeutics Inc
Surface Oncology Inc
Synthon Holdings BV
TOT Biopharm Co Ltd
Trillium Therapeutics Inc
Waterstone Hanxbio Pty Ltd
Leukocyte Surface Antigen CD47 (Antigenic Surface Determinant Protein OA3 or Integrin Associated Protein or Protein MER6 or CD47) - Drug Profiles
ABP-160 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
ALX-148 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Appendix
List of Tables
Number of Products under Development by Stage of Development, H2 2019
Number of Products under Development by Therapy Areas, H2 2019
Number of Products under Development by Indications, H2 2019
Number of Products under Development by Indications, H2 2019 (Contd..1), H2 2019
Number of Products under Development by Indications, H2 2019 (Contd..2), H2 2019
Number of Products under Development by Indications, H2 2019 (Contd..3), H2 2019
Number of Products under Development by Companies, H2 2019
Number of Products under Development by Companies, H2 2019 (Contd..1)
Products under Development by Companies, H2 2019
Products under Development by Companies, H2 2019 (Contd..1), H2 2019
Products under Development by Companies, H2 2019 (Contd..2), H2 2019
Products under Development by Companies, H2 2019 (Contd..3), H2 2019
Products under Development by Companies, H2 2019 (Contd..4), H2 2019
Products under Development by Companies, H2 2019 (Contd..5), H2 2019
Products under Development by Companies, H2 2019 (Contd..6), H2 2019
Products under Development by Companies, H2 2019 (Contd..7), H2 2019
Products under Development by Companies, H2 2019 (Contd..8), H2 2019
Number of Products under Investigation by Universities/Institutes, H2 2019
Products under Investigation by Universities/Institutes, H2 2019
Number of Products by Stage and Mechanism of Actions, H2 2019
Number of Products by Stage and Route of Administration, H2 2019
Number of Products by Stage and Molecule Type, H2 2019
Pipeline by Abpro Corp, H2 2019
Pipeline by ALX Oncology Inc, H2 2019
Pipeline by Arch Oncology Inc, H2 2019
Pipeline by Aurigene Discovery Technologies Ltd, H2 2019
Pipeline by Beijing Hanmi Pharmaceutical Co Ltd, H2 2019
Pipeline by Biocad, H2 2019
Pipeline by Bristol-Myers Squibb Co, H2 2019
Pipeline by EpicentRx Inc, H2 2019
Pipeline by Forty Seven Inc, H2 2019
Pipeline by GeneScience Pharmaceuticals Co Ltd, H2 2019
Pipeline by GigaGen Inc, H2 2019
Pipeline by Hummingbird Bioscience Pte Ltd, H2 2019
Pipeline by I-Mab Biopharma Co Ltd, H2 2019
Pipeline by ImmuneOncia Therapeutics LLC, H2 2019
Pipeline by ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd, H2 2019
Pipeline by Innovent Biologics Inc, H2 2019
Pipeline by Jiangsu Hengrui Medicine Co Ltd, H2 2019
Pipeline by KAHR medical Ltd, H2 2019
Pipeline by LynkCell Inc, H2 2019
Pipeline by MesaGen LLC, H2 2019
Pipeline by NovImmune SA, H2 2019
Pipeline by Opsyon, H2 2019
Pipeline by Paradigm Shift Therapeutics LLC, H2 2019
Pipeline by Phanes Therapeutics Inc, H2 2019
Pipeline by PharmAbcine Inc, H2 2019
Pipeline by Shanghai Henlius Biotech Inc, H2 2019
Pipeline by Sorrento Therapeutics Inc, H2 2019
Pipeline by Surface Oncology Inc, H2 2019
Pipeline by Synthon Holdings BV, H2 2019
Pipeline by TOT Biopharm Co Ltd, H2 2019
Pipeline by Trillium Therapeutics Inc, H2 2019
Pipeline by Waterstone Hanxbio Pty Ltd, H2 2019
Dormant Products, H2 2019
Dormant Products, H2 2019 (Contd..1), H2 2019
Discontinued Products, H2 2019
List of Figures
Number of Products under Development by Stage of Development, H2 2019
Number of Products under Development by Therapy Areas, H2 2019
Number of Products under Development by Top 10 Indications, H2 2019
Number of Products by Stage and Mechanism of Actions, H2 2019
Number of Products by Routes of Administration, H2 2019
Number of Products by Stage and Routes of Administration, H2 2019
Number of Products by Molecule Types, H2 2019
Number of Products by Stage and Molecule Types, H2 2019
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- Abpro Corp
- ALX Oncology Inc
- Arch Oncology Inc
- Aurigene Discovery Technologies Ltd
- Beijing Hanmi Pharmaceutical Co Ltd
- Biocad
- Bristol-Myers Squibb Co
- EpicentRx Inc
- Forty Seven Inc
- GeneScience Pharmaceuticals Co Ltd
- GigaGen Inc
- Hummingbird Bioscience Pte Ltd
- I-Mab Biopharma Co Ltd
- ImmuneOncia Therapeutics LLC
- ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd
- Innovent Biologics Inc
- Jiangsu Hengrui Medicine Co Ltd
- KAHR medical Ltd
- LynkCell Inc
- MesaGen LLC
- NovImmune SA
- Opsyon
- Paradigm Shift Therapeutics LLC
- Phanes Therapeutics Inc
- PharmAbcine Inc
- Shanghai Henlius Biotech Inc
- Sorrento Therapeutics Inc
- Surface Oncology Inc
- Synthon Holdings BV
- TOT Biopharm Co Ltd
- Trillium Therapeutics Inc
- Waterstone Hanxbio Pty Ltd
