High Grade Glioma Drug Profiles and Clinical Trials- Global Trends and Analysis Review, H1 2018

  • ID: 4460272
  • Report
  • Region: Global
  • 177 Pages
  • VPA Research
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This Research Analyzes the Evolution of Glioma Clinical Trial Trends Across Countries and Regions

This Glioma clinical trials report provides comprehensive analysis and trends in global Glioma disease clinical trials. The research work analyzes the evolution of Glioma clinical trial trends across countries and regions.

The report focuses on drugs and therapies being evaluated for Glioma treatment in active clinical development phases including phase 1, phase 2, phase 3 and phase 4 clinical trials. The report also provides trials information by region, key countries, phases, trial status and sponsor types.

Our experienced database team dynamically updates the clinical trials data from several sources including Clinical trial registries, conferences, journals and company releases etc. Further, data is presented in user friendly manner offering quick access to Glioma clinical trials.

Major drugs under development in Glioma are provided in the report along with their details of mechanism of action, route of administration, target, therapy, molecule and class.

Scope of the Report:

  • Number of Glioma clinical trials across regions -Asia and Oceania, Europe, Middle East Africa and Americas
  •  Trial information by Phase and Subjects recruited
  •  Trial information by status, type, sponsor type
  •  Drugs used for treatment of Glioma
  •  Both observational and interventional trials analyzed
  •  Success rates of trials are analyzed
  •  Trends in enrollment over the past ten years identified
  •  Leading sponsors of Glioma clinical trials worldwide are listed

Reasons to Buy:

  • Track competition and design competitive advantages
  •  Identify right partners to associate with for further research
  •  Evaluate potential opportunities available in further clinical trials of the disease
  •  Formulate business development strategies through success rates of clinical trials
  •  Identify quick markets for recruiting subjects based on trials count by each market

Glioma - The condition occurs when the glial cells in the brain are affected and account for around one - third of all brain tumors. On the basis of location, these are classified as supratentorial (above tentorium) and infratentorial (below tenotrium).

On the basis of pace of development, these are categorized as Low grade (grades 1 and 2) and high grade (3 and 4). Treatment options vary with the grade of the disease, but most often it includes a combination of medicine, surgery, radiation and chemo therapies.

Malignant Glioma - Malignant Glioma is the most regular subtypes of glioma condition occurring in patients aged between 60 and 80. The condition is classified as grade 3 and grade 4, which comprises anaplastic high - grade gliomas and glioblastomas respectively.

High Grade Glioma - Malignant or high - grade glioma tumors are categorized as Grade 3 and Grade 4. Of this Grade 3 tumor types include -

Anaplastic astrocytoma - The rare disease type comprises an estimated one - third of all astrocytoma types. Often observed in older persons, the condition can occur in any aged person. Astrocytoma emerges from star shaped cells in the brain, called astrocytes.

Anaplastic oligodendroglioma - It is a rare type of malignant tumor occurring mainly between 45 and 50 years of age. They possess abnormal genetic material and unique molecular, clinical, and histological characteristics and are important to diagnose.

Anaplastic oligoastrocytoma - Oligoastrocytoma occurs when either oligodendrocytes and astrocytes or both grow rapidly, causing formation of tumors in the brain. The term ‘Anaplastic’ refers to condition when tumor can spread into nearby tissues. They occur in Cerebrum area.

Anaplastic ependymoma - The fast growing subtype occurs primarily in posterior fossa part. The tumor cells show rapid growth pace and are associated with a less favorable prognosis and have higher possibility to infiltrate around the brain or disseminate into cerebrospinal fluid resulting in drop metastases.

Glioblastoma - The grade 4 type condition is further classified as primary and secondary types. The primary subtype occurs without earlier diagnosis of low grade tumors while the secondary type arouses from development of grade 2 or 3 subtypes. Tumor occurs as a result of accumulation of different mutations.

Pontine Gliomas - Diffuse intrinsic pontine glioma (DIPG) is an aggressive type of malignant glioma, arising from glioma tissue. As these are observed in the bottom area of the brain, they are tough to be treated. It is observed mostly in children.

Low Grade Glioma (LGGs) or often referred to as Grade - 1 and 2 tumors, arouse from brain cells including astrocytes and oligodendrocytes. Causing mild and large seizures, the Glioma type is treated through a combination of surgery, chemotherapy, and radiation on the basis of disease condition. The condition is primarily observed in young and healthy individuals. Compared to high grade Glioma, these patients survive for long periods and lead quality life as this is a slow growth disease.

On the basis of appearance under microscope and genetic modifications, Low grade gliomas are classified as -
Pilocytic astrocytomas — Observed in adults aging less than 25 and progresses very slowly compared to other types

Diffuse astrocytomas - Most observed subtype of low - grade glioma. Late 30’s individuals are the most affected age. Type of modification in IDH isocitrate - dehydrogenase gene determines the sub - types of Diffuse astrocytomas.

Oligodendrogliomas - Slow growing tumors, having mutation in the IDH gene in terms of missing 1p and 19q chromosomes.

Gangliogliomas - Posesses both gliomas and tumor related characteristics.

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1 Table of Contents
1.1 List of Figures
1.2 List of Tables

2 Executive Summary
2.1 Report Guide
2.2 Key Findings
2.2.1 Overview of Global Clinical Trials Initiated in 2017
2.2.2 Average Enrolment by Country, 2010 - 2017
2.2.3 Prominent Companies in Global High Grade Glioma Trials, 2010 - 2017

3 High Grade Glioma Drugs in Ongoing and Completed Trials
3.1 Prominent Drugs in Development and Approved Stages for High Grade Glioma
3.2 High Grade Glioma Product Snapshots
3.2.1 High Grade Glioma Drug Profiles

4 Global High Grade Glioma Clinical Trial Research Trends
4.1 Clinical Trials by Top 10 Countries, 2010- 2017
4.1.1 Clinical Trials by Country
4.1.2 Number of Ongoing/Planned Trial Locations in Each Country
4.2 Subjects Recruited by Top 10 Countries, 2010- 2017
4.2.1 Total Enrolment by Country
4.3 Clinical Trials by Region, 2010 - 2017
4.4 Subjects Recruited by Region, 2010 - 2017
4.5 Clinical Trials by Year, 2010 - 2017
4.6 Subjects Recruited by Year, 2010 - 2017
4.7 Clinical Trials by Development Phase, 2010 - 2017
4.7.1 Clinical Trials by Phase
4.8 Subjects Recruited by Development Phase, 2010 - 2017
4.9 Clinical Trials by Status, 2010 - 2017
4.10 Subjects Recruited by Trial Status, 2010 - 2017
4.11 Clinical Trials by Sponsor Type, 2010 - 2017
4.12 Subjects Recruited by Sponsor Type, 2010 - 2017
4.13 Clinical Trials by Economy Type, 2010 - 2017
4.14 Clinical Trials and Subjects Recruited by Study Type, 2010 - 2017

5 Europe High Grade Glioma Clinical Trial Research Trends
5.1 Clinical Trials by Top Countries in Europe, 2010 - 2017
5.1.1 Europe, Clinical Trials by Country
5.2 Subjects Recruited by Top Countries in Europe, 2010 - 2017
5.2.1 Europe, Total Enrolment by Country
5.3 Europe, Clinical Trials by Year, 2010 - 2017
5.4 Europe, Clinical Trials by Development Phase, 2010 - 2017
5.5 Europe, Clinical Trials by Trial Status, 2010 - 2017
5.6 Europe, Clinical Trials by Sponsor Type, 2010 - 2017

6 Eastern Mediterranean High Grade Glioma Clinical Trial Research Trends
6.1 Clinical Trials by Top Countries in Eastern Mediterranean, 2010 - 2017
6.1.1 Eastern Mediterranean, Clinical Trials by Country

7 North America High Grade Glioma Clinical Trial Research Trends
7.1 Clinical Trials by Top Countries in North America, 2010 - 2017
7.1.1 North America, Clinical Trials by Country
7.2 Subjects Recruited by Top Countries in North America, 2010 - 2017
7.2.1 North America, Total Enrolment by Country
7.3 North America, Clinical Trials by Year, 2010 - 2017
7.4 North America, Clinical Trials by Development Phase, 2010 - 2017
7.5 North America, Clinical Trials by Trial Status, 2010 - 2017
7.6 North America, Clinical Trials by Sponsor Type, 2010 - 2017

8 South East Asia High Grade Glioma Clinical Trial Research Trends
8.1 Clinical Trials by Top Countries in South East Asia, 2010 - 2017
8.1.1 South East Asia, Clinical Trials by Country

9 Western Pacific High Grade Glioma Clinical Trial Research Trends
9.1 Clinical Trials by Top Countries in Western Pacific, 2010 - 2017
9.1.1 Western Pacific, Clinical Trials by Country
9.2 Subjects Recruited by Top Countries in Western Pacific, 2010 - 2017
9.2.1 Western Pacific, Total Enrolment by Country
9.3 Western Pacific, Clinical Trials by Year, 2010 - 2017
9.4 Western Pacific, Clinical Trials by Development Phase, 2010 - 2017
9.5 Western Pacific, Clinical Trials by Trial Status, 2010 - 2017
9.6 Western Pacific, Clinical Trials by Sponsor Type, 2010 - 2017

10 Recent Clinical Trials- Snapshots
10.1 High Grade Glioma Trial Snapshots - 2018
10.2 High Grade Glioma Trial Snapshots - 2017
10.3 High Grade Glioma Trial Snapshots - 2016
10.4 High Grade Glioma Trial Snapshots - 2015
10.5 High Grade Glioma Trial Snapshots - 2014
10.6 High Grade Glioma Trial Snapshots - 2013
10.7 High Grade Glioma Trial Snapshots - 2012
10.8 High Grade Glioma Trial Snapshots - 2011
10.9 High Grade Glioma Trial Snapshots - 2010

11 Appendix
11.2 Sources and Research Methodology

1.1 List of Figures
Figure 1: High Grade Glioma- Average Enrolment by Country, 2010 - 2017
Figure 2: High Grade Glioma- Country wise Clinical Trials, 2010 - 2017
Figure 3: High Grade Glioma- Country wise Recruiting Sites, 2010 - 2017
Figure 4: High Grade Glioma- Country wise Subjects Recruited, 2010 - 2017
Figure 5: Global High Grade Glioma Clinical Trials Participation Share by Region, 2010 - 2017
Figure 6: Global High Grade Glioma Subjects Recruited by Region, 2010 - 2017
Figure 7: Global High Grade Glioma Clinical Trials by Year, 2010 - 2017
Figure 8: Global High Grade Glioma Subjects Recruited by Year, 2010 - 2017
Figure 9: Global High Grade Glioma Trials by Phase, 2010 - 2017
Figure 10: Global High Grade Glioma - Subjects Recruited by Phase, 2010 - 2017
Figure 11: Global High Grade Glioma - Clinical Trials by Recruitment Status, 2010 - 2017
Figure 12: Global High Grade Glioma - Subjects Recruited by Trial Status, 2010 - 2017
Figure 13: Global High Grade Glioma - Clinical Trials by Sponsor Type, 2010 - 2017
Figure 14: Global High Grade Glioma - Subjects Recruited by Trial Status, 2010 - 2017
Figure 15: Global High Grade Glioma - Clinical Trials by Type of Economy, 2010 - 2017
Figure 16: Europe High Grade Glioma - Country wise Clinical Trials, 2010 - 2017
Figure 17: Europe High Grade Glioma - Country wise Subjects Recruited, 2010 - 2017
Figure 18: Europe High Grade Glioma - Year wise Clinical Trials, 2010 - 2017
Figure 19: Europe High Grade Glioma Trials by Phase, 2010 - 2017
Figure 20: Europe High Grade Glioma Clinical Trials by Recruitment Status, 2010 - 2017
Figure 21: Europe High Grade Glioma Clinical Trials by Sponsor Type, 2010 - 2017
Figure 22: North America High Grade Glioma - Country wise Clinical Trials, 2010 - 2017
Figure 23: North America High Grade Glioma - Country wise Subjects Recruited, 2010 - 2017
Figure 24: North America High Grade Glioma - Year wise Clinical Trials, 2010 - 2017
Figure 25: North America High Grade Glioma Trials by Phase, 2010 - 2017
Figure 26: North America High Grade Glioma - Clinical Trials by Recruitment Status, 2010 - 2017
Figure 27: North America High Grade Glioma - Clinical Trials by Sponsor Type, 2010 - 2017
Figure 28: Western Pacific High Grade Glioma - Country wise Clinical Trials, 2010 - 2017
Figure 29: Western Pacific High Grade Glioma - Country wise Subjects Recruited, 2010 - 2017
Figure 30: Western Pacific High Grade Glioma - Year wise Clinical Trials, 2010 - 2017
Figure 31: Western Pacific High Grade Glioma -  Trials by Phase, 2010- 2017
Figure 32: Western Pacific High Grade Glioma - Clinical Trials by Recruitment Status, 2010 - 2017
Figure 33: Western Pacific High Grade Glioma - Clinical Trials by Sponsor Type, 2010 - 2017

1.2 List of Tables
Table 1: High Grade Glioma Pipeline Drug Profiles - Type, Class, Route of Administration, Mechanism of Action, Target
Table 2: High Grade Glioma Pipeline Drug Profiles - Type, Class, Route of Administration, Mechanism of Action, Target
Table 3: High Grade Glioma Pipeline Drug Profiles - Type, Class, Route of Administration, Mechanism of Action, Target
Table 4: High Grade Glioma Pipeline Drug Profiles - Type, Class, Route of Administration, Mechanism of Action, Target
Table 5: High Grade Glioma Pipeline Drug Profiles - Type, Class, Route of Administration, Mechanism of Action, Target
Table 6: High Grade Glioma Pipeline Drug Profiles - Type, Class, Route of Administration, Mechanism of Action, Target
Table 7: High Grade Glioma- Region wise Clinical Trials, 201 0- 2017
Table 8: High Grade Glioma- Region wise Subjects Recruited, 2010 - 2017
Table 9: Global High Grade Glioma- Clinical Trials and Subjects by Trial Type, 2010 - 2017
Table 10: High Grade Glioma Trial Snapshots - 2018
Table 11: High Grade Glioma Trial Snapshots - 2017
Table 12: High Grade Glioma Trial Snapshots - 2017
Table 13: High Grade Glioma Trial Snapshots - 2017
Table 14: High Grade Glioma Trial Snapshots - 2017
Table 15: High Grade Glioma Trial Snapshots - 2017
Table 16: High Grade Glioma Trial Snapshots - 2017
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Table 18: High Grade Glioma Trial Snapshots - 2017
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Table 20: High Grade Glioma Trial Snapshots - 2017
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Table 22: High Grade Glioma Trial Snapshots - 2017
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Table 24: High Grade Glioma Trial Snapshots - 2017
Table 25: High Grade Glioma Trial Snapshots - 2017
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Table 27: High Grade Glioma Trial Snapshots - 2017
Table 28: High Grade Glioma Trial Snapshots - 2017
Table 29: High Grade Glioma Trial Snapshots - 2017
Table 30: High Grade Glioma Trial Snapshots - 2017
Table 31: High Grade Glioma Trial Snapshots - 2017
Table 32: High Grade Glioma Trial Snapshots - 2016
Table 33: High Grade Glioma Trial Snapshots - 2016
Table 34: High Grade Glioma Trial Snapshots - 2016
Table 35: High Grade Glioma Trial Snapshots - 2016
Table 36: High Grade Glioma Trial Snapshots - 2016
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Table 38: High Grade Glioma Trial Snapshots - 2016
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Table 46: High Grade Glioma Trial Snapshots - 2016
Table 47: High Grade Glioma Trial Snapshots - 2016
Table 48: High Grade Glioma Trial Snapshots - 2016
Table 49: High Grade Glioma Trial Snapshots - 2016
Table 50: High Grade Glioma Trial Snapshots - 2016
Table 51: High Grade Glioma Trial Snapshots - 2015
Table 52: High Grade Glioma Trial Snapshots - 2015
Table 53: High Grade Glioma Trial Snapshots - 2015
Table 54: High Grade Glioma Trial Snapshots - 2015
Table 55: High Grade Glioma Trial Snapshots - 2015
Table 56: High Grade Glioma Trial Snapshots - 2015
Table 57: High Grade Glioma Trial Snapshots - 2015
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Table 67: High Grade Glioma Trial Snapshots - 2014
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Table 79: High Grade Glioma Trial Snapshots - 2014
Table 80: High Grade Glioma Trial Snapshots - 2014

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