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Drying Technologies for Pharmaceutical Applications

  • ID: 4471262
  • Book
  • March 2019
  • Region: Global
  • 480 Pages
  • John Wiley and Sons Ltd
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Focusing on the application of various drying technologies to the processing of pharmaceuticals and biologicals, this is a comprehensive technical overview of novel as well as standard methods, addressing such issues as why drying is required and what needs to be considered when implementing this process during drug product development.

The editors are renowned experts from the pharmaceutical industry and have assembled here leaders from industry and academia to share their experiences and offer insights. The authors concentrate on industrial solutions, outlining various drying technologies from an application–oriented point of view and with regard to real–world challenges in the field of drug product development. They describe well established methods, including freeze and spray drying, alongside promising next–generation technologies, possible improvements, limitations, synergies and future directions.
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1.Table of content


Impact of water removal and critical physical properties

3.History of drying

4.Physical state of dried solids and impact of water

Current applications of drying technologies

5.Food industry and others

Pharmaceutical applications

6.Drug product development

6.1.Key considerations for the development of liquid vs dry dosage forms

6.2.Small molecule APIs


6.4.Vaccines and microorganisms

6.5.Drug delivery systems



7.2.Current status, including survey of commercial products and limitations

7.3.Future direction

8.Spray drying


8.2.Particle engineering

8.3.Current status

8.4.Future direction

9.Next generation drying technologies

9.1.Desired attributes and requirements for implementation

9.2.Spray freeze–drying

9.3.Microwave drying

9.4.Foam drying


Formulation considerations for solid dosage preparation

10.Solid state stabilization and formulation considerations

11.Impact of water on stability of dried pharmaceuticals

12.Reconstitution and high concentration formulations


13.Challenges and considerations for new technology implementation

14.Synergy with development of process analytical technologies

Future perspectives

15.Future direction

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Satoshi Ohtake
Ken–ichi Izutsu
David Lechuga–Ballesteros
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