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Growth Hormone Secretagogue Receptor Type 1 - Pipeline Review, H2 2020

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    Drug Pipelines

  • 87 Pages
  • October 2020
  • Region: Global
  • Global Markets Direct
  • ID: 5189149
1h Free Analyst Time
1h Free Analyst Time

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Summary

According to the recently published report 'Growth Hormone Secretagogue Receptor Type 1 - Pipeline Review, H2 2020'; Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) pipeline Target constitutes close to 17 molecules. Out of which approximately 16 molecules are developed by companies and remaining by the universities/institutes.

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Growth hormone secretagogue receptor (GHSR) also known as ghrelin receptor, is a G protein-coupled receptor that binds ghrelin. Ghrelin is an appetite-regulating factor secreted from peripheral organs via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity.

The report 'Growth Hormone Secretagogue Receptor Type 1 - Pipeline Review, H2 2020' outlays comprehensive information on the Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies/Universities.

It also reviews key players involved in Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 1, 3, 2, 8 and 1 respectively. Similarly, the universities portfolio in Phase II stages comprises 1 molecules, respectively. Report covers products from therapy areas Oncology, Central Nervous System, Toxicology, Cardiovascular, Gastrointestinal, Genetic Disorders, Hormonal Disorders, Metabolic Disorders, Genito Urinary System And Sex Hormones, Infectious Disease, Musculoskeletal Disorders and Women's Health which include indications Cancer Anorexia-Cachexia Syndrome, Growth Hormone Deficiency, Obesity, Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome), Acute Ischemic Stroke, Alcohol Addiction, Born Small For Gestational Age (SGA), Cachexia, Chemotherapy Effects, Chronic Kidney Disease (Chronic Renal Failure), Constipation, Diabetic Gastroparesis, Endocrine Gland Disorders, Fatigue, Ischemia, Prader-Willi Syndrome (PWS), Sepsis, Traumatic Brain Injury and Turner Syndrome.

Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope
  • The report provides a snapshot of the global therapeutic landscape for Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)
  • The report reviews Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics

Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

Introduction
  • Report Coverage

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Overview
Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Therapeutics Development
  • Products under Development by Stage of Development
  • Products under Development by Therapy Area
  • Products under Development by Indication
  • Products under Development by Companies
  • Products under Development by Universities/Institutes

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Therapeutics Assessment
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Companies Involved in Therapeutics Development
  • Aeterna Zentaris Inc
  • Allergan Ltd
  • AstraZeneca Plc
  • Extend Biosciences Inc
  • Helsinn Group
  • Lumos Pharma Inc
  • Millendo Therapeutics Inc
  • Oxeia Biopharmaceuticals Inc
  • Pfizer Inc
  • RaQualia Pharma Inc
  • TheraSource LLC
  • Zeria Pharmaceutical Co Ltd

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Drug Profiles
anamorelin hydrochloride - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

AZ-12861903 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

EXT-405 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

EXT-418 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

HM-04 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

ibutamoren mesylate - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

livoletide - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

macimorelin acetate - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

OXE-103 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Peptide to Agonize GHSR for Acute Ischemic Stroke, Acute Radiation Syndrome and Sepsis - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

PF-05190457 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

relamorelin - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

RQ-00433412 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Small Molecule to Antagonize Ghrelin Receptor for Obesity - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Small Molecules to Agonize GHSR for Cachexia - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Synthetic Peptide to Modulate GHSR for Chronic Kidney Disease - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Z-505 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Dormant ProductsGrowth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Discontinued Products
Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Product Development Milestones
  • Featured News & Press Releases
  • Oct 21, 2020: Oxeia Biopharmaceuticals announces initiation of phase 2 trial for OXE103 for the treatment of concussions
  • Sep 16, 2020: Aeterna Zentaris provides corporate update
  • Sep 08, 2020: Aeterna Zentaris announced presentation of positive results from first pediatric study of Macimorelin at the 22nd European Congress of Endocrinology
  • Jul 31, 2020: Aeterna Zentaris announces continued expansion of intellectual property portfolio for Macimorelin with additional patent applications
  • Jul 30, 2020: Aeterna Zentaris announces abstract of results from first pediatric study of macimorelin accepted for presentation at the 22nd European Congress of Endocrinology
  • Apr 07, 2020: Aeterna Zentaris announces EMA decision to accept a modification to an agreed pediatric investigation plan for macimorelin
  • Apr 06, 2020: Millendo Therapeutics announces topline results for pivotal phase 2b study of Livoletide in patients with Prader-Willi Syndrome (PWS)
  • Apr 06, 2020: Aeterna Zentaris announces positive results in dose-finding pediatric study of macimorelin
  • Mar 12, 2020: Aeterna Zentaris announces settlement of previously disclosed class-action lawsuit
  • Feb 12, 2020: Aeterna Zentaris to present at Noble Capital Markets' 16th Annual Investor Conference
  • Jan 28, 2020: Aeterna Zentaris announces completion of patient recruitment in dose-finding pediatric study of Macimorelin
  • Dec 18, 2019: Aeterna Zentaris announces publication of GHD Management Guidelines
  • Nov 14, 2019: Millendo closes enrolment for first part of livoletide’s ZEPHYR trial
  • Nov 07, 2019: Millendo Therapeutics to Host Prader-Willi Syndrome (PWS) Breakfast Symposium on Thursday, November 14, 2019
  • Sep 26, 2019: Millendo Therapeutics to present at Prader-Willi Syndrome Conferences

Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact
  • Disclaimer

List of Tables
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Indication, H2 2020
  • Number of Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020 (Contd..1), H2 2020
  • Number of Products under Investigation by Universities/Institutes, H2 2020
  • Products under Investigation by Universities/Institutes, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Stage and Route of Administration, H2 2020
  • Number of Products by Stage and Molecule Type, H2 2020
  • Pipeline by Aeterna Zentaris Inc, H2 2020
  • Pipeline by Allergan Ltd, H2 2020
  • Pipeline by AstraZeneca Plc, H2 2020
  • Pipeline by Extend Biosciences Inc, H2 2020
  • Pipeline by Helsinn Group, H2 2020
  • Pipeline by Lumos Pharma Inc, H2 2020
  • Pipeline by Millendo Therapeutics Inc, H2 2020
  • Pipeline by Oxeia Biopharmaceuticals Inc, H2 2020
  • Pipeline by Pfizer Inc, H2 2020
  • Pipeline by RaQualia Pharma Inc, H2 2020
  • Pipeline by TheraSource LLC, H2 2020
  • Pipeline by Zeria Pharmaceutical Co Ltd, H2 2020
  • Dormant Products, H2 2020
  • Dormant Products, H2 2020 (Contd..1), H2 2020
  • Dormant Products, H2 2020 (Contd..2), H2 2020
  • Discontinued Products, H2 2020

List of Figures
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Top 10 Indications, H2 2020
  • Number of Products by Mechanism of Actions, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Routes of Administration, H2 2020
  • Number of Products by Stage and Routes of Administration, H2 2020
  • Number of Products by Molecule Types, H2 2020
  • Number of Products by Stage and Molecule Types, H2 2020

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Aeterna Zentaris Inc
  • Allergan Ltd
  • AstraZeneca Plc
  • Extend Biosciences Inc
  • Helsinn Group
  • Lumos Pharma Inc
  • Millendo Therapeutics Inc
  • Oxeia Biopharmaceuticals Inc
  • Pfizer Inc
  • RaQualia Pharma Inc
  • TheraSource LLC
  • Zeria Pharmaceutical Co Ltd