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Growth/Differentiation Factor 8 - Pipeline Review, H2 2020

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    Drug Pipelines

  • 78 Pages
  • October 2020
  • Region: Global
  • Global Markets Direct
  • ID: 5189148
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Summary

Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Myostatin also known as growth differentiation factor 8 or GDF-8 is a myokine a protein produced and released by myocytes. This protein is part of the transforming growth factor beta (TGFβ) superfamily. Myostatin is found almost in muscles used for movement, where it is active both before and after birth. This protein normally restrains muscle growth, ensuring that muscles do not grow too large.

Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) pipeline Target constitutes close to 9 molecules. The molecules developed by companies in Phase III, Phase II, Phase I and Preclinical stages are 1, 3, 3 and 2 respectively. Report covers products from therapy areas Central Nervous System, Musculoskeletal Disorders, Genetic Disorders, Hematological Disorders and Oncology which include indications Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis, Duchenne Muscular Dystrophy, Anemia, Fibrodysplasia Ossificans Progressiva (Myositis Ossificans Progressiva), Limb-Girdle Muscular Dystrophy, Muscle Wasting Disorders, Myelodysplastic Syndrome, Myelofibrosis, Neuromuscular Disorders, Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), Sarcopenia and Thalassemia.

The latest report GrowthDifferentiation Factor 8 - Pipeline Review, H2 2020, outlays comprehensive information on the Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) targeted therapeutics development with respective active and dormant or discontinued projects.

The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope
  • The report provides a snapshot of the global therapeutic landscape for Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN)
  • The report reviews Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) targeted therapeutics

Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

Introduction
  • Report Coverage

Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Overview
Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Therapeutics Development
  • Products under Development by Stage of Development
  • Products under Development by Therapy Area
  • Products under Development by Indication
  • Products under Development by Companies

Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Therapeutics Assessment
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type

Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Companies Involved in Therapeutics Development
  • Acceleron Pharma Inc
  • Biogen Inc
  • Bioleaders Corp
  • Chugai Pharmaceutical Co Ltd
  • PeptiDream Inc
  • Pfizer Inc
  • Regeneron Pharmaceuticals Inc
  • Scholar Rock Inc

Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Drug Profiles
ALG-802 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

apitegromab - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

BIIB-110 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

BLSM-22 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

domagrozumab - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

luspatercept - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

RG-70240 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Synthetic Peptide to Inhibit Myostatin for Duchenne Muscular Dystrophy - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

trevogrumab - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Dormant ProductsGrowth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Discontinued Products
Growth/Differentiation Factor 8 (Myostatin or GDF8 or MSTN) - Product Development Milestones
  • Featured News & Press Releases
  • Sep 30, 2020: Scholar Rock presents data for SRK-015 at the World Muscle Society 2020 Virtual Congress
  • Sep 29, 2020: Health Canada approves REBLOZYL (luspatercept), new class of treatment for adult patients living with beta thalassemia
  • Aug 27, 2020: Scholar Rock announces issuance of U.S. patent providing composition of matter protection for SRK-015
  • Aug 13, 2020: Scholar Rock announces that SRK-015 has received rare pediatric disease designation from U.S. FDA for the treatment of spinal muscular atrophy
  • Jun 26, 2020: European Commission approves Reblozyl (luspatercept) for the treatment of transfusion-dependent anemia in adult patients with myelodysplastic syndromes or beta thalassemia
  • Jun 12, 2020: Scholar Rock presents clinical and preclinical data for SRK-015 at the 2020 Virtual Cure SMA Research and Clinical Care Meeting
  • May 20, 2020: Acceleron announces presentations on REBLOZYL (luspatercept-aamt) at the 2020 American Society of Clinical Oncology and European Hematology Association Virtual Annual Meetings
  • May 18, 2020: Scholar Rock presents baseline demographics data from the SRK-015 TOPAZ trial at the American Academy of Neurology Conference
  • Apr 30, 2020: Novel drug shows promise for inherited blood disorder
  • Apr 30, 2020: Reblozyl (luspatercept) receives positive CHMP opinion for the treatment of adults with Anemia in Beta Thalassemia and Myelodysplastic Syndromes
  • Apr 03, 2020: U.S. Food and Drug Administration (FDA) approves Reblozyl (luspatercept-aamt), the first and only erythroid maturation agent, to treat anemia in adults with lower-risk myelodysplastic syndromes (MDS)
  • Mar 26, 2020: New England Journal of Medicine Publishes results from Pivotal Phase 3 BELIEVE Trial of Reblozyl (luspatercept-aamt) in Adult Patients With Beta Thalassemia
  • Mar 24, 2020: Scholar Rock presents data for SRK-015 at the Muscular Dystrophy Association Clinical and Scientific Conference
  • Feb 06, 2020: Scholar Rock presents data for SRK-015 at the SMA Europe 2nd International Scientific Congress
  • Jan 09, 2020: New England journal of medicine publishes results of pivotal phase 3 Reblozyl (luspatercept-aamt) MEDALIST trial

Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact
  • Disclaimer

List of Tables
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Indication, H2 2020
  • Number of Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020 (Contd..1), H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Stage and Route of Administration, H2 2020
  • Number of Products by Stage and Molecule Type, H2 2020
  • Pipeline by Acceleron Pharma Inc, H2 2020
  • Pipeline by Biogen Inc, H2 2020
  • Pipeline by Bioleaders Corp, H2 2020
  • Pipeline by Chugai Pharmaceutical Co Ltd, H2 2020
  • Pipeline by PeptiDream Inc, H2 2020
  • Pipeline by Pfizer Inc, H2 2020
  • Pipeline by Regeneron Pharmaceuticals Inc, H2 2020
  • Pipeline by Scholar Rock Inc, H2 2020
  • Dormant Products, H2 2020
  • Dormant Products, H2 2020 (Contd..1), H2 2020
  • Discontinued Products, H2 2020

List of Figures
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Top 10 Indications, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Routes of Administration, H2 2020
  • Number of Products by Stage and Routes of Administration, H2 2020
  • Number of Products by Molecule Types, H2 2020
  • Number of Products by Stage and Molecule Types, H2 2020

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Acceleron Pharma Inc
  • Biogen Inc
  • Bioleaders Corp
  • Chugai Pharmaceutical Co Ltd
  • PeptiDream Inc
  • Pfizer Inc
  • Regeneron Pharmaceuticals Inc
  • Scholar Rock Inc