Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Pipeline Review, H1 2018

  • ID: 4518520
  • Drug Pipelines
  • 60 pages
  • Global Markets Direct
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FEATURED COMPANIES

  • Actinogen Medical Ltd
  • AstraZeneca Plc
  • Boehringer Ingelheim GmbH
  • F. Hoffmann-La Roche Ltd
  • Laboratorios SALVAT SA
  • Poxel SA
  • MORE
Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Pipeline Review, H1 2018

Summary:

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - 11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.

In these tissues HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. This enzyme plays an important role in obesity and insulin resistance.

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) pipeline Target constitutes close to 15 molecules. Out of which approximately 12 molecules are developed by companies and remaining by the universities/institutes.

The molecules developed by companies in Phase II, Phase I, Preclinical and Discovery stages are 2, 1, 7 and 2 respectively. Similarly, the universities portfolio in Preclinical stages comprises 3 molecules, respectively.

Report covers products from therapy areas Metabolic Disorders, Ophthalmology, Central Nervous System, Cardiovascular, Immunology and Musculoskeletal Disorders which include indications Type 2 Diabetes, Obesity, Ocular Hypertension, Open-Angle Glaucoma, Alzheimer's Disease, Cardiomyopathy, Cushing's Syndrome, Dementia Associated With Alzheimer's Disease, Inflammation, Intracranial Hypertension, Metabolic Syndrome and Muscle Atrophy.

The latest report Corticosteroid 11 Beta Dehydrogenase Isozyme 1 - Pipeline Review, H1 2018, outlays comprehensive information on the Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

It also reviews key players involved in Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) targeted therapeutics development with respective active and dormant or discontinued projects.

The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope:
  • The report provides a snapshot of the global therapeutic landscape for Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146)
  • The report reviews Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) targeted therapeutics
Reasons for Purchase:
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146)
  • Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
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Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Actinogen Medical Ltd
  • AstraZeneca Plc
  • Boehringer Ingelheim GmbH
  • F. Hoffmann-La Roche Ltd
  • Laboratorios SALVAT SA
  • Poxel SA
  • MORE
Introduction

Report Coverage

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Overview

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Therapeutics Development

Products under Development by Stage of Development

Products under Development by Therapy Area

Products under Development by Indication

Products under Development by Companies

Products under Development by Universities/Institutes

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Therapeutics Assessment

Assessment by Mechanism of Action

Assessment by Route of Administration

Assessment by Molecule Type

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Companies Involved in Therapeutics Development

Actinogen Medical Ltd

AstraZeneca Plc

Boehringer Ingelheim GmbH

Connexios Life Sciences Pvt Ltd

F. Hoffmann-La Roche Ltd

Hyundai Pharmaceutical Co Ltd

Laboratorios SALVAT SA

Poxel SA

Shionogi & Co Ltd

SK Chemicals Co Ltd

Toray Industries Inc

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Drug Profiles

AZD-4017 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

BI-135558 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

CNX-1049 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

HIS-388 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

HOB-046 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

KR-66344 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

NCE-402 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

RO-5093151 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Small Molecule to Inhibit HSD11B1 for Muscle Atrophy - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Small Molecules to Inhibit 11 Beta Hydroxysteroid Dehydrogenase 1 for Metabolic Diseases - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Small Molecules to Inhibit 11 Beta-Hydroxysteroid Dehydrogenase 1 for Type 2 Diabetes - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

SVT-63 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

SVT-88 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

TR-013A - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

UE-2343 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Dormant Products

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Discontinued Products

Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - Product Development Milestones

Featured News & Press Releases

Mar 21, 2018: Mid-Way Point Reached in Landmark Alzheimer’s Trial - XanADu

Feb 12, 2018: Actinogen Medical: Strong Recruitment Progress in Alzheimer's Trial

Feb 06, 2018: Actinogen Medical: New data supports link between stress hormone cortisol and worsening cognition

Dec 01, 2017: Amgen Pioneer Dr George Morstyn Joins Actinogen Board

Nov 29, 2017: Early Efficacy and Safety Data Read-Out Planned for Alzheimer’s Trial

Nov 22, 2017: Leading Alzheimer's Researchers to Address Shareholders

Oct 30, 2017: Actinogen Medical: September Quarterly Update

Oct 16, 2017: Actinogen to be Showcased at Key Conferences

Oct 11, 2017: Actinogen Medical: Final major market patent granted for Xanamem

Sep 07, 2017: Actinogen Medical: First patient completes landmark Alzheimer's disease trial

Aug 16, 2017: First UK patient treated in ground-breaking Alzheimer’s clinical trial

Jul 26, 2017: Actinogen Medical Provides Update on Xanamem

Jul 19, 2017: Actinogen Medical presenting at Bioshares Biotech 2017 Summit

Jun 22, 2017: First US patients treated in landmark Alzheimers disease trial

Jun 01, 2017: First UK site goes live in global Alzheimer’s disease clinical trial

Appendix

Methodology

Coverage

Secondary Research

Primary Research

Expert Panel Validation

Contact Us

Disclaimer

List of Tables

Number of Products under Development by Stage of Development, H1 2018

Number of Products under Development by Therapy Areas, H1 2018

Number of Products under Development by Indication, H1 2018

Number of Products under Development by Companies, H1 2018

Products under Development by Companies, H1 2018

Number of Products under Investigation by Universities/Institutes, H1 2018

Products under Investigation by Universities/Institutes, H1 2018

Number of Products by Stage and Mechanism of Actions, H1 2018

Number of Products by Stage and Route of Administration, H1 2018

Number of Products by Stage and Molecule Type, H1 2018

Pipeline by Actinogen Medical Ltd, H1 2018

Pipeline by AstraZeneca Plc, H1 2018

Pipeline by Boehringer Ingelheim GmbH, H1 2018

Pipeline by Connexios Life Sciences Pvt Ltd, H1 2018

Pipeline by F. Hoffmann-La Roche Ltd, H1 2018

Pipeline by Hyundai Pharmaceutical Co Ltd, H1 2018

Pipeline by Laboratorios SALVAT SA, H1 2018

Pipeline by Poxel SA, H1 2018

Pipeline by Shionogi & Co Ltd, H1 2018

Pipeline by SK Chemicals Co Ltd, H1 2018

Pipeline by Toray Industries Inc, H1 2018

Dormant Products, H1 2018

Dormant Products, H1 2018 (Contd..1), H1 2018

Discontinued Products, H1 2018

List of Figures

Number of Products under Development by Stage of Development, H1 2018

Number of Products under Development by Therapy Areas, H1 2018

Number of Products under Development by Top 10 Indications, H1 2018

Number of Products by Stage and Mechanism of Actions, H1 2018

Number of Products by Routes of Administration, H1 2018

Number of Products by Stage and Routes of Administration, H1 2018

Number of Products by Stage and Molecule Type, H1
Note: Product cover images may vary from those shown
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  • Actinogen Medical Ltd
  • AstraZeneca Plc
  • Boehringer Ingelheim GmbH
  • Connexios Life Sciences Pvt Ltd
  • F. Hoffmann-La Roche Ltd
  • Hyundai Pharmaceutical Co Ltd
  • Laboratorios SALVAT SA
  • Poxel SA
  • Shionogi & Co Ltd
  • SK Chemicals Co Ltd
  • Toray Industries Inc
Note: Product cover images may vary from those shown
5 of 5
Note: Product cover images may vary from those shown
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