This Market Spotlight report covers the Peripheral T-Cell Lymphoma (PTCL) market, comprising key marketed and pipeline drugs, clinical trials, upcoming events, recent events and analyst opinion, probability of success, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Key Takeaways
Key Takeaways
- The publisher estimates that in 2017, there were approximately 19,950 incident cases of peripheral T-cell lymphoma (PTCL) worldwide, and forecasts that number to increase to 23,880 incident cases by 2026.
- It is estimated that the majority of diagnosed cases were in males in 2017.
- The incidence of PTCL is highest among older individuals aged 60+ years. The approved drugs in the PTCL space focus on a wide variety of targets. These drugs are administered via the intravenous and oral routes.
- The majority of industry-sponsored drugs in active clinical development for PTCL are in Phase II. Therapies in development for PTCL focus on a wide variety of targets. These therapies are administered via the oral and intravenous routes.
- High-impact upcoming events for drugs in the PTCL space comprise topline Phase II trial results for IPH4102 and an expected supplemental CHMP opinion for Adcetris.
- The overall likelihood of approval of a Phase I hematologic asset is 8.6%, and the average probability a drug advances from Phase III is 59.1%. Drugs, on average, take 9.5 years from Phase I to approval, compared to 9.6 years in the overall oncology space.
- The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for PTCL have been in the early and mid-phases of development, with 93% of trials in Phase I–II, and only 7% in Phase III–IV.
- The US has a substantial lead in the number of PTCL clinical trials globally. France and the UK lead the major European markets, while China has the top spot in Asia.
- Clinical trial activity in the PTCL space is dominated by completed trials. Bristol Myers Squibb has the highest number of completed clinical trials for PTCL, with 11 trials.
- Bristol Myers Squibb leads industry sponsors with the highest overall number of clinical trials for PTCL, followed by Seagen and Takeda.
Table of Contents
OVERVIEWKEY TAKEAWAYSTREATMENTEPIDEMIOLOGYMARKETED DRUGSPIPELINE DRUGSKEY UPCOMING EVENTSPROBABILITY OF SUCCESSREVENUE OPPORTUNITYBIBLIOGRAPHYAPPENDIX
DISEASE BACKGROUND
RECENT EVENTS AND ANALYST OPINION
LICENSING AND ASSET ACQUISITION DEALS
CLINICAL TRIAL LANDSCAPE
LIST OF FIGURES
LIST OF TABLES