Human Reproductive and Prenatal Genetics presents the latest material from a detailed molecular, cellular and translational perspective. Considering its timeliness and potential international impact, this all-inclusive and authoritative work is ideal for researchers, students, and clinicians worldwide. Currently, there are no comprehensive books covering the field of human reproductive and prenatal genetics. As such, this book aims to be among the largest and most useful references available.
- Features chapter contributions from leading international scientists and clinicians
- Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization and implantation, in vitro culture of the human embryo for the study of post-implantation development, and more
- Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and -omics based approaches
Part I. Reproductive Tract Development and Gametogenesis 1. Developmental Genetics of the Male Reproductive System 2. Genetics and genomics of early gonad development 3. Genetic Analysis of Meiotic Chromosome Dynamics and Fertility 4. Aging and Sperm Chromatin Quality 5. In Vitro Spermatogenesis from Embryonic Stem Cells 6. Developmental Genetics of the Female Reproductive Tract 7. Molecular Genetics of Oogenesis 8. Epigenetic Control of Oocyte Development 9. RNA Binding Protein Networks and Translational Control in Oocytes 10. Translational Regulation of Gene Expression During Oogenesis and Pre-Implantation Embryo Development 11. MicroRNAs in Gametes and Preimplantation Embryos: Clinical Implications
Part II. Embryo Implantation, Placenta Development and Pregnancy 12. Mechanisms of Embryo Implantation and Implantation Failure 13. Transcriptomics of the Human Endometrium and Embryo Implantation 14. Maternal Recognition of Pregnancy 15. Human Genetics at the Fetal-Maternal Interface 16. Epigenetic Modifications in the Human Placenta 17. Micro RNA in the Human Placenta and Pre-eclampsia 18. Genetics and Genomics of Preterm Birth 19. The Intergenerational Effects on Fetal Programming
Part III. Infertility and Assisted Reproductive Technology 20. Genetic Testing in Male Infertility 21. Genetics and Genomics of Endometriosis 22. Genetics and Genomics of Primary Ovarian Insufficiency 23. Genetics of Polycystic Ovary Syndrome 24. Genetics and Genomics of Recurrent Pregnancy Loss 25. Human Genetics and Assisted Reproduction 26. Uterine Transplantation
Part IV. Preimplantation/Prenatal Genetic Diagnosis and Screening 27. Preimplantation Genetic Diagnosis (PGD) and Screening (PGS) 28. Molecular Genetics in Preimplantation Diagnosis and Screening 29. Epidemiology and Genetics of Human Aneuploidy 30. Next Generation Sequencing for Gene Panels and Clinical Exomes 31. Chromosomal Microarrays and Exome Sequencing for Diagnosis of Fetal Abnormalities 32. Noninvasive Prenatal Testing for Genetic Diseases 33. Non-Invasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility and Limitations 34. Prenatal diagnosis and treatment of genetic steroid disorders 35. Application of Gene-Editing Technologies in Embryos and Their Potential for Gene Therapy
Dr. Leung is a Professor at the University of British Columbia's Department of Obstetrics & Gynecology and former Associate Dean in the Faculty of Medicine at UBC. Dr. Leung received his PhD from Western University. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Distinguished Scholar Award from the Michael Smith Foundation for Health Research and a Senior Scientist Award from the BC Children Hospital Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung's research focuses on hormonal determinants of women's reproductive health. His publication record to date includes 400 papers, 350 abstracts, 22 book chapters and 7 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for more than 100 graduate students, postdoctoral fellows and visiting scientists.
Dr. Jie Qiao is the Chief Scientist of the Ministry of Science and Technology of China, the Incumbent Director of the North Third Hospital Department of Obstetrics and Gynecology, the Chinese Medical Association branch chairman for Reproductive Medicine, and the Beijing Medical Association branch chairman for Reproductive Medicine. She has been engaged in reproductive health-related clinical and basic research throughout her career, including as a visiting scholar at the University of Hong Kong and as a post-doctoral researcher at Stanford University. Her research has focused on gametes fertilization, infertility and embryo implantation mechanisms, and polycystic ovary syndrome pathogenesis among other topics. Dr. Jie Qiao has published more than 250 paper publications in peer reviewed journals on topics related to reproductive health.