Negative Pressure Wound Therapy (NPWT) - Medical Devices Pipeline Assessment, 2018

1 Table of Contents

2 Introduction
2.1 Negative Pressure Wound Therapy (NPWT) Overview

3 Products under Development
3.1 Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Stage of Development
3.2 Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Territory
3.3 Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Regulatory Path
3.4 Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Estimated Approval Date

4 Negative Pressure Wound Therapy (NPWT) - Pipeline Products under Development by Companies
4.1 Negative Pressure Wound Therapy (NPWT) Companies - Pipeline Products by Stage of Development
4.2 Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Stage of Development

5 Negative Pressure Wound Therapy (NPWT) Companies and Product Overview
5.1 Acelity L.P. Inc. Company Overview
5.1.1 Acelity L.P. Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.2 Adept Medical Ltd Company Overview
5.2.1 Adept Medical Ltd Pipeline Products & Ongoing Clinical Trials Overview
5.3 Applied Tissue Technologies LLC Company Overview
5.3.1 Applied Tissue Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview
5.4 Invacare Corporation Company Overview
5.4.1 Invacare Corporation Pipeline Products & Ongoing Clinical Trials Overview
5.5 MLM Biologics Inc Company Overview
5.5.1 MLM Biologics Inc Pipeline Products & Ongoing Clinical Trials Overview
5.6 Montana State University Company Overview
5.6.1 Montana State University Pipeline Products & Ongoing Clinical Trials Overview
5.7 Otivio AS Company Overview
5.7.1 Otivio AS Pipeline Products & Ongoing Clinical Trials Overview
5.8 Shieldheart Medtech AB Company Overview
5.8.1 Shieldheart Medtech AB Pipeline Products & Ongoing Clinical Trials Overview
5.9 Smith & Nephew Plc Company Overview
5.9.1 Smith & Nephew Plc Pipeline Products & Ongoing Clinical Trials Overview
5.10 University of Pisa Company Overview
5.10.1 University of Pisa Pipeline Products & Ongoing Clinical Trials Overview
5.11 Wake Forest Baptist Medical Center Company Overview
5.11.1 Wake Forest Baptist Medical Center Pipeline Products & Ongoing Clinical Trials Overview
5.12 Worldwide Innovative Healthcare, Inc. Company Overview
5.12.1 Worldwide Innovative Healthcare, Inc. Pipeline Products & Ongoing Clinical Trials Overview

6 Negative Pressure Wound Therapy (NPWT) - Recent Developments
6.1 May 17, 2018: NanoVibronix Provides Business Update for the First Quarter 2018
6.2 May 08, 2018: Sonoma Pharmaceuticals Names Marc Umscheid Chief Operating Officer
6.3 May 08, 2018: Smith & Nephew: Change of Directorate
6.4 May 07, 2018: Invacare Reports Results for First Quarter 2018
6.5 May 03, 2018: Smith & Nephew First Quarter 2018 Trading Report
6.6 May 03, 2018: Cardinal Health Announces Third-quarter Results for Fiscal Year 2018
6.7 May 01, 2018: One Call Partners with Acelity to Improve Patient Adherence to Advanced Wound Therapy
6.8 Apr 25, 2018: New Meta-analysis Demonstrates the Effectiveness of PICO NPWT in Helping to Prevent Surgical Site Complications versus Standard Care
6.9 Apr 04, 2018: Namal Nawana appointed Chief Executive Officer of Smith & Nephew
6.10 Apr 02, 2018: NanoVibronix Provides Year-End 2017 Business Update and Files 10-K
6.11 Mar 20, 2018: Governor Abbott Announces Smith & Nephew Adding New Jobs In Fort Worth
6.12 Mar 01, 2018: Smith & Nephew: Change in Directorate
6.13 Feb 22, 2018: Invacare Appoints Kathleen Leneghan Chief Financial Officer
6.14 Feb 08, 2018: Smith & Nephew Fourth Quarter Trading and Full Year 2017 Results
6.15 Feb 08, 2018: Cardinal Health Reports Second-quarter Results for Fiscal Year 2018
6.16 Feb 07, 2018: Smith & Nephew announces European launch of new PICO 7 Single Use Negative Pressure Wound Therapy System
6.17 Feb 07, 2018: Cardinal Health Adds Akhil Johri to its Board of Directors
6.18 Feb 07, 2018: Invacare Corporation Announces Financial Results for the Fourth Quarter and Full Year Ended December 31, 2017
6.19 Feb 07, 2018: Sonoma Pharmaceuticals Reports Record Total Revenue of $4.8 million for Third Quarter FY 2018 with Year over Year Product Revenue Growth of 46%
6.20 Jan 31, 2018: Smith & Nephew Appoints Roland Diggelmann As Non-Executive Director
6.21 Jan 31, 2018: Appointment of Roland Diggelmann as Non-Executive Director
6.22 Jan 25, 2018: Lohmann & Rauscher: Personnel Change in Executive Board of L&R
6.23 Dec 21, 2017: NanoVibronix CEO Brian Murphy Provides Business Update Letter to Shareholders
6.24 Dec 07, 2017: Invacare Announces North America Reduction in Force as Part of Continued Cost Realignment
6.25 Nov 27, 2017: New Independent Study Results Add to Growing Body of Evidence That PREVENA Therapy Helps Reduce Surgical Site Infections and Complications
6.26 Nov 09, 2017: Sonoma Pharmaceuticals Reports Robust Top Line Growth for Second Quarter FY 2018 with 61% Product Revenue Growth and Total Revenue of $4.3 Million
6.27 Nov 07, 2017: Invacare Reports Results for Third Quarter 2017
6.28 Nov 06, 2017: Cardinal Health Reports First-quarter Results for Fiscal Year 2018
6.29 Nov 06, 2017: Cardinal Health Outlines Leadership Succession Plan
6.30 Nov 03, 2017: Smith & Nephew Third Quarter 2017 Trading Report
6.31 Nov 02, 2017: Invacare Announces Departure of Chief Financial Officer
6.32 Oct 25, 2017: New microbiology laboratory enables effective development of antimicrobial wound dressings
6.33 Oct 09, 2017: Smith & Nephew: Notice of Chief Executive Officer’s intention to retire by end of 2018
6.34 Oct 09, 2017: Notice of Chief Executive Officer’s intention to retire by end of 2018
6.35 Oct 02, 2017: Smith & Nephew Announces Directorate Change
6.36 Oct 01, 2017: Molnlycke to establish R&D innovation unit in AstraZeneca’s BioVentureHub
6.37 Sep 18, 2017: Smith & Nephew Announces Change in Board of Directors
6.38 Sep 12, 2017: Smith & Nephew: Appointment of Marc Owen as Non-Executive Director
6.39 Aug 21, 2017: PREVENA Incision Management System Shown to Reduce Incisional Pain and Associated Narcotic Use Among Obese Study Patients Undergoing Cesarean Delivery
6.40 Aug 21, 2017: Invacare Appoints Barbara Bodem to Board of Directors
6.41 Aug 08, 2017: Sonoma Pharmaceuticals Reports Financial Results for First Quarter of Fiscal Year 2018
6.42 Aug 07, 2017: Invacare Reports Results for Second Quarter 2017
6.43 Aug 02, 2017: Cardinal Health Reports Q4 and Fiscal 2017 Results, Provides 2018 Guidance
6.44 Jul 27, 2017: Smith & Nephew Second Quarter and First Half 2017 Results
6.45 Jul 04, 2017: Appointment of Angie Risley as Non-Executive Director and Chairman Elect of the Remuneration Committee
6.46 Jun 26, 2017: Invacare Announces Closure of China Manufacturing Facility in Line with Strategic Transformation

7 Appendix
7.1 Methodology
7.2 About
7.3 Contact
7.4 Disclaimer

List of Tables
Table 1: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Stage of Development
Table 2: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Territory
Table 3: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Regulatory Path
Table 4: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Estimated Approval Date
Table 5: Negative Pressure Wound Therapy (NPWT) Companies - Pipeline Products by Stage of Development
Table 6: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Stage of Development
Table 7: Acelity L.P. Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 8: Negative Pressure Regenerative Medicine - Chronic Wounds - Product Status
Table 9: Negative Pressure Regenerative Medicine - Chronic Wounds - Product Description
Table 10: Negative Pressure Regenerative Medicine - Hard Tissue - Product Status
Table 11: Negative Pressure Regenerative Medicine - Hard Tissue - Product Description
Table 12: Adept Medical Ltd Pipeline Products & Ongoing Clinical Trials Overview
Table 13: Wound Pressure Device - Product Status
Table 14: Wound Pressure Device - Product Description
Table 15: Applied Tissue Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview
Table 16: Next Generation Negative Pressure Wound Therapy Device - Product Status
Table 17: Next Generation Negative Pressure Wound Therapy Device - Product Description
Table 18: Invacare Corporation Pipeline Products & Ongoing Clinical Trials Overview
Table 19: Negative-Pressure Wound Therapy System - Product Status
Table 20: Negative-Pressure Wound Therapy System - Product Description
Table 21: MLM Biologics Inc Pipeline Products & Ongoing Clinical Trials Overview
Table 22: Wound Matrix - Negative Pressure Wound Therapy - Product Status
Table 23: Wound Matrix - Negative Pressure Wound Therapy - Product Description
Table 24: Montana State University Pipeline Products & Ongoing Clinical Trials Overview
Table 25: Tissue Cooling Negative Pressure Wound Therapy System - Product Status
Table 26: Tissue Cooling Negative Pressure Wound Therapy System - Product Description
Table 27: Otivio AS Pipeline Products & Ongoing Clinical Trials Overview
Table 28: FlowOx - Next Version - Product Status
Table 29: FlowOx - Next Version - Product Description
Table 30: Shieldheart Medtech AB Pipeline Products & Ongoing Clinical Trials Overview
Table 31: ShieldHeart Protection Device - Product Status
Table 32: ShieldHeart Protection Device - Product Description
Table 33: Smith & Nephew Plc Pipeline Products & Ongoing Clinical Trials Overview
Table 34: RENASYS TOUCH Connect - Product Status
Table 35: RENASYS TOUCH Connect - Product Description
Table 36: University of Pisa Pipeline Products & Ongoing Clinical Trials Overview
Table 37: Smart Wearable And Autonomous Negative Pressure Device - Product Status
Table 38: Smart Wearable And Autonomous Negative Pressure Device - Product Description
Table 39: Wake Forest Baptist Medical Center Pipeline Products & Ongoing Clinical Trials Overview
Table 40: Mechanical Tissue Resuscitation Device - Product Status
Table 41: Mechanical Tissue Resuscitation Device - Product Description
Table 42: Worldwide Innovative Healthcare, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 43: Wound-Pump - Product Status
Table 44: Wound-Pump - Product Description
Table 45: Glossary

List of Figures
Figure 1: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Stage of Development
Figure 2: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Territory
Figure 3: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Regulatory Path
Figure 4: Negative Pressure Wound Therapy (NPWT) - Pipeline Products by Estimated Approval Date 9