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Diarrhea and Constipation Drug Development Pipeline Review, 2018

  • ID: 4606287
  • Report
  • 93 pages
  • GBI Research
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FEATURED COMPANIES

  • Aegis Therapeutics LLC
  • AzurRx BioPharma Inc
  • DiscoveryBiomed Inc
  • Johnson & Johnson
  • Nippon Shinyaku Co Ltd
  • RaQualia Pharma Inc
  • MORE
Diarrhea and Constipation Drug Development Pipeline Review, 2018

Summary

Diarrhea is a contagious gastrointestinal infection occurring mostly due to unhygienic conditions. Diarrhea may be related to a viral or bacterial infection and is sometimes the result of food poisoning. Symptoms include nausea, abdominal pain, cramping, bloating, dehydration, fever, bloody stools, frequent urge to evacuate the bowels and incontinence. There are 54 products in development for this indication and molecular targets present in the pipeline landscape include cystic fibrosis transmembrane conductance regulator and glucagon like peptide 2 receptor.

Constipation refers to the infrequent or difficult passing of stool. Constipation occurs when bowel movements become difficult or less frequent. Symptoms of constipation include swollen abdomen or abdominal pain, pain and vomiting. The predisposing factors include eating disorders, irritable bowel syndrome, and hypothyroidism, overuse of laxatives (stool softeners) which, over time, weaken the bowel muscles, stress, inadequate water intake and inadequate fiber in the diet. There are 25 products in development for this indication and molecular targets present in the pipeline landscape include 5-hydroxytryptamine receptor 4 and heat stable enterotoxin receptor.

Companies operating in this pipeline space include Synthetic Biologics, Allergan and Ardelyx.

This report “Diarrhea and Constipation Drug Development Pipeline Review, 2018”provides an overview of the pipeline landscape for diarrhea and constipation. It provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for diarrhea and constipation, and features dormant and discontinued products.

Scope
  • Which companies are the most active within each pipeline?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in this disease area?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration
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Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Aegis Therapeutics LLC
  • AzurRx BioPharma Inc
  • DiscoveryBiomed Inc
  • Johnson & Johnson
  • Nippon Shinyaku Co Ltd
  • RaQualia Pharma Inc
  • MORE

1.1 List of Tables
1.2 List of Figures

2 Introduction
2.1 Diarrhea and Constipation Report Coverage
2.2 Constipation - Overview
2.3 Diarrhea - Overview

3 Therapeutics Development
3.1 Constipation
3.2 Diarrhea

4 Therapeutics Assessment
4.1 Constipation
4.2 Diarrhea

5 Companies Involved in Therapeutics Development
5.1 Constipation
5.2 Diarrhea

6 Dormant Projects
6.1 Constipation
6.2 Diarrhea

7 Discontinued Products
7.1 Constipation
7.2 Diarrhea

8 Product Development Milestones
8.1 Constipation
8.2 Diarrhea

9 Appendix
9.1 Methodology
9.2 Coverage
9.3 Secondary Research
9.4 Primary Research
9.5 Expert Panel Validation
9.6 Contact Us
9.7 Disclaimer

1.1 List of Tables
Table 1: Number of Products under Development for Constipation
Table 2: Number of Products under Development by Companies, Constipation
Table 3: Number of Products under Development by Universities/Institutes, Constipation
Table 4: Products under Development by Companies, Constipation
Table 5: Products under Development by Universities/Institutes, Constipation
Table 6: Number of Products under Development for Diarrhea
Table 7: Number of Products under Development by Companies, Diarrhea
Table 8: Number of Products under Development by Universities/Institutes, Diarrhea
Table 9: Products under Development by Companies, Diarrhea
Table 10: Products under Development by Universities/Institutes, Diarrhea
Table 11: Number of Products by Stage and Target, Constipation
Table 12: Number of Products by Stage and Mechanism of Action, Constipation
Table 13: Number of Products by Stage and Route of Administration, Constipation
Table 14: Number of Products by Stage and Molecule Type, Constipation
Table 15: Number of Products by Stage and Target, Diarrhea
Table 16: Number of Products by Stage and Mechanism of Action, Diarrhea
Table 17: Number of Products by Stage and Route of Administration, Diarrhea
Table 18: Number of Products by Stage and Molecule Type, Diarrhea
Table 19: Constipation - Pipeline by Allergan Plc
Table 20: Constipation - Pipeline by Ardelyx Inc
Table 21: Constipation - Pipeline by Braintree Laboratories Inc
Table 22: Constipation - Pipeline by Dong-A ST Co Ltd
Table 23: Constipation - Pipeline by EA Pharma Co Ltd
Table 24: Constipation - Pipeline by Ironwood Pharmaceuticals Inc
Table 25: Constipation - Pipeline by Johnson & Johnson
Table 26: Constipation - Pipeline by MallInckrodt Plc
Table 27: Constipation - Pipeline by NGM Biopharmaceuticals Inc
Table 28: Constipation - Pipeline by RaQualia Pharma Inc
Table 29: Constipation - Pipeline by Sanwa Kagaku Kenkyusho Co Ltd
Table 30: Constipation - Pipeline by SK Biopharmaceuticals Co Ltd
Table 31: Constipation - Pipeline by Sumitomo Dainippon Pharma Co Ltd
Table 32: Constipation - Pipeline by Synthetic Biologics Inc
Table 33: Constipation - Pipeline by Vanda Pharmaceuticals Inc
Table 34: Constipation - Pipeline by Yuhan Corp
Table 35: Constipation - Pipeline by Zensun (Shanghai) Sci & Tech Co Ltd
Table 36: Diarrhea - Pipeline by Aegis Therapeutics LLC
Table 37: Diarrhea - Pipeline by Akthelia Pharmaceuticals Ltd
Table 38: Diarrhea - Pipeline by Albireo Pharma Inc
Table 39: Diarrhea - Pipeline by Allergan Plc
Table 40: Diarrhea - Pipeline by Ardelyx Inc
Table 41: Diarrhea - Pipeline by AzurRx BioPharma Inc
Table 42: Diarrhea - Pipeline by Bharat Biotech Ltd
Table 43: Diarrhea - Pipeline by Chongqing Zhifei Biological Products Co Ltd
Table 44: Diarrhea - Pipeline by Cosmo Pharmaceuticals NV
Table 45: Diarrhea - Pipeline by DiscoveryBiomed Inc
Table 46: Diarrhea - Pipeline by Ferring International Center SA
Table 47: Diarrhea - Pipeline by GP Pharm SA
Table 48: Diarrhea - Pipeline by Kuhnil Pharmaceutical Co Ltd
Table 49: Diarrhea - Pipeline by Metacrine Inc
Table 50: Diarrhea - Pipeline by Miyarisan Pharmaceutical Company Ltd
Table 51: Diarrhea - Pipeline by Napo Pharmaceuticals Inc
Table 52: Diarrhea - Pipeline by Nippon Shinyaku Co Ltd
Table 53: Diarrhea - Pipeline by Novartis AG
Table 54: Diarrhea - Pipeline by Pfizer Inc
Table 55: Diarrhea - Pipeline by Prokarium Ltd
Table 56: Diarrhea - Pipeline by Protagonist Therapeutics Inc
Table 57: Diarrhea - Pipeline by RaQualia Pharma Inc
Table 58: Diarrhea - Pipeline by RedHill Biopharma Ltd
Table 59: Diarrhea - Pipeline by RxBio Inc
Table 60: Diarrhea - Pipeline by Scandinavian Biopharma Holding AB

1.2 List of Figures
Figure 1: Number of Products under Development for Constipation
Figure 2: Number of Products under Development by Companies, Constipation
Figure 3: Number of Products under Development for Diarrhea
Figure 4: Number of Products under Development by Companies, Diarrhea
Figure 5: Number of Products under Development by Universities/Institutes, Diarrhea
Figure 6: Number of Products by Targets, Constipation
Figure 7: Number of Products by Stage and Targets, Constipation
Figure 8: Number of Products by Top 10 Mechanism of Actions, Constipation
Figure 9: Number of Products by Stage and Top 10 Mechanism of Actions, Constipation
Figure 10: Number of Products by Routes of Administration, Constipation
Figure 11: Number of Products by Stage and Routes of Administration, Constipation
Figure 12: Number of Products by Molecule Types, Constipation
Figure 13: Number of Products by Stage and Molecule Types, Constipation
Figure 14: Number of Products by Top 10 Targets, Diarrhea
Figure 15: Number of Products by Stage and Top 10 Targets, Diarrhea
Figure 16: Number of Products by Top 10 Mechanism of Actions, Diarrhea
Figure 17: Number of Products by Stage and Top 10 Mechanism of Actions, Diarrhea
Figure 18: Number of Products by Routes of Administration, Diarrhea
Figure 19: Number of Products by Stage and Routes of Administration, Diarrhea
Figure 20: Number of Products by Top 10 Molecule Types, Diarrhea
Figure 21: Number of Products by Stage and Top 10 Molecule Types, Diarrhea

Note: Product cover images may vary from those shown
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  • Aegis Therapeutics LLC
  • Akthelia Pharmaceuticals Ltd
  • Albireo Pharma Inc
  • Allergan Plc
  • Ardelyx Inc
  • AzurRx BioPharma Inc
  • Bharat Biotech Ltd
  • Braintree Laboratories Inc
  • Chongqing Zhifei Biological Products Co Ltd
  • Cosmo Pharmaceuticals NV
  • Diarrhea
  • DiscoveryBiomed Inc
  • Dong-A ST Co Ltd
  • EA Pharma Co Ltd
  • Ferring International Center SA
  • GP Pharm SA
  • Ironwood Pharmaceuticals Inc
  • Johnson & Johnson
  • Kuhnil Pharmaceutical Co Ltd
  • MallInckrodt Plc
  • Metacrine Inc
  • Miyarisan Pharmaceutical Company Ltd
  • Napo Pharmaceuticals Inc
  • NGM Biopharmaceuticals Inc
  • Nippon Shinyaku Co Ltd
  • Novartis AG
  • Pfizer Inc
  • Prokarium Ltd
  • Protagonist Therapeutics Inc
  • RaQualia Pharma Inc
  • RedHill Biopharma Ltd
  • RxBio Inc
  • Sanwa Kagaku Kenkyusho Co Ltd
  • Scandinavian Biopharma Holding AB
  • SK Biopharmaceuticals Co Ltd
  • Sublimity Therapeutics Ltd
  • Sumitomo Dainippon Pharma Co Ltd
  • Summit Therapeutics Plc
  • Synthetic Biologics Inc
  • Syntiron LLC
  • Tasly Pharmaceutical Group Co Ltd
  • Vanda Pharmaceuticals Inc
  • Wuhan Institute of Biological Products Co Ltd
  • Yuhan Corp
  • Zealand Pharma AS
  • Zensun (Shanghai) Sci & Tech Co Ltd
Note: Product cover images may vary from those shown
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Note: Product cover images may vary from those shown
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