Biochemistry of Collagens, Laminins and Elastin. Edition No. 2

  • ID: 4720942
  • Book
  • 416 Pages
  • Elsevier Science and Technology
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Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Second Edition provides researchers and students with up-to-date data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions may be viewed as endocrine function and how this knowledge can be further exploited to modulate fibrotic disease.

  • Provides an updated, comprehensive introduction to collagen and structural proteins
  • Gives insights into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation
  • Includes eight new chapters, including one on how collagen biomarkers are used in clinical research to support drug development, and in precision medicine
  • Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states
  • Proves the importance of proteins for collagen assembly, function and durability
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1. Type I Collagen
2. Type II Collagen
3. Type III Collagen
4. Type IV Collagen
5. Type V Collagen
6. Type VI Collagen
7. Type VII Collagen
8. Type VIII Collagen
9. Type IX Collagen
10. Type X Collagen
11. Type XI Collagen
12. Type XII Collagen
13. Type XIII Collagen
14. Type XIV Collagen
15. Type XV Collagen
16. Type XVI Collagen
17. Type XVII Collagen
18. Type XVIII Collagen
19. Type XIX Collagen
20. Type XX Collagen
21. Type XXI Collagen
22. Type XXII Collagen
23. Type XXIII Collagen
24. Type XXIV Collagen
25. Type XXV Collagen
26. Type XXVI Collagen
27. Type XXVII Collagen
28. Type XXVIII Collagen
29. Laminins
30. Elastin
31. The Collagen Chaperones
32. Collagen Diseases
33. The Signals of the ECM
34. The Roles of Collagens in Cancer and Fibrosis
35. Use of Collagen Biomarkers in Clinical Research
36. Confounding Factors for Serological Measurements
37. Can We Use Collagens as Regulatory Biomarkers
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Karsdal, Morten
Morten Karsdal has been CEO of Nordic Bioscience A/S since June 2010.

Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.

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