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Global Clinical Trials - Current Trends and Recent Advancement

  • ID: 4745322
  • Report
  • Region: Global
  • 65 Pages
  • CBR Pharma Insights
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Global Clinical Trials Current Trends and Recent Advancement

Summary

There has been tremendous innovation over the past decade, with the emergence of new drugs and the increasing adoption of targeted therapies in the pharmaceutical industry, where they invest significant capital and resources into preserving the patient’s life and the subsequent profits of products which take several years to develop. The clinical trial industry has seen a tremendous increase, with major levers to reduce ineffectiveness and safety concerns.

Major sponsors are focusing on oncology as cancer cases and related deaths continue to increase globally. While new cancer therapies are being identified offering new options for patients, many patients continue to live with cancer as a chronic disease. Nevertheless, many still succumb to their disease.

As cancer is a major worldwide challenge, it is of little surprise that of all clinical trials registered, oncology is the greatest in number for any year during the past decade. Hence, oncology remains the top therapy area followed by CNS and infectious diseases.

Asia-Pacific market share has increased for conducting clinical trials as most of Asia has a treatment-naive; skilled investigators; robust clinical infrastructure; faster patient recruitment and lower costs relative to the West; and high-quality output as factors behind the CRO and industry’s growth.

The disruptive potential of digital technology could drive the most value in the pharmaceutical industry in the future. Pharma companies are planning to start or have already started experimenting with Artificial Intelligence (AI), mobile health (mHealth), Big Data, wearable, internet of things and remote wireless monitoring.

The report "Global Clinical Trials Current Trends and Recent Advancement”, provides an in-depth assessment of the current trends in the number of clinical trials globally, Top 10 therapy areas, geography-wise clinical trials, YOY clinical trials in top 10 therapy area.

An overview of clinical guidelines reforms has also been provided to show how regulation affects the clinical trial's cost and duration, and how innovative clinical trials has solved those problems. This report also provides key insights into how CRO companies and Technological advancement has helped the pharma companies in cost and time.

Now clinical trials are conducted on a global level and especially in those areas where the cost of conducting clinical trials is less such as in Pharma emerging markets. An overview of technological advancements has also been provided with the collaboration of pharmaceutical companies.

Scope

  • How many clinical trials being conducted worldwide?
  • Which are top therapy areas in terms of the number of clinical trials?
  • Which type of sponsor vital in terms of conducting clinical trials in different therapeutic areas?
  • Year over year clinical trials in Top 10 therapy areas.
  • Which are the top 10 indications in top therapy areas?
  • Top 10 indications in overall therapy areas.
  • How many patients are being recruited in the top 10 therapy areas?
  • The average duration of clinical trials in the top 10 therapy area.
  • What is average recruitment size and clinical trials by Top 10 sponsor?
  • What is the total number of deals completed between institutions and industries?
  • How many clinical trials are ongoing in different geographical areas?
  • What are the main reasons which caused termination and withdrawal of clinical trials?

Reasons to buy

This report will allow you to:

  • Understand the analysis of the clinical trials YOY (2007-2018) in Phase 0, Phase I, Phase II, Phase III, and Phase IV.
  • Understand the analysis of top 10 therapy areas by the number of clinical trials in 2007-2018 and in top therapy area top 10 indications.
  • Gain an understanding of the major sponsor and major area of research and development.
  • Understand the analysis of YOY FDA approval of precision medicine and primary endpoint analysis in oncology.
  • Understand the clinical reforms in different countries and the benefits of those changes.
  • Understand the Novel approach of clinical trial design in oncology.
  • Understand the role of clinical supply chain management to conduct clean in an effective manner.
  • Understand the role of technological advancement in clinical trials and the importance of CRO for the same.
Note: Product cover images may vary from those shown
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1. Executive summary

2. Clinical trial analysis – overview

  • Significant Increase in Clinical Investigations During Last Decade With Highest in Phase II
  • Spotlight is on Oncology Due to Increase in Trial Accrual and Supportive Regulatory Policies
  • Large Number of Clinical Trials From Institution Bring Innovation Into the Pipeline
  • Top Therapy Areas to Maintain a Grip to Lead The Market
  • Industry Sponsored Clinical Trial Trend, Oncology, Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, CNS, Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Infectious Diseases, Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Metabolic Disorder, Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Cardiovascular Disorder, Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Gastrointestinal Disorder, Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Immunological Disease , Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Respiratory Disorder , Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Musculoskeletal Disorder , Global – 2013-2018(Q3)
  • Industry Sponsored Clinical Trial Trend, Hematological Disorder, Global – 2013-2018(Q3)
  • Diabetes Outnumbers Breast Cancer when Trials Are Analyzed by Indication
  • Proper Trial Recruitment Offers a Clear Advantage Resulting in Cost and Time Savings
  • Increase in Clinical Trial Duration Benefiting the Trial Design
  • Increasing Focus on Precision Medicine Leading to Longer Trial Duration and Reduced Recruitment Size
  • Diverse Therapeutic Expertise of Top 10 Global Pharmaceutical Companies
  • Average Recruitment Size Varies Depending on focused Therapy Areas by top 10 Companies
  • Big Pharma Is Attracted To Early-stage Deal With Institutions
  • Global Migration Of Clinical Research with Increasing Focus on Asia-Pacific
  • Withdrawal Whys And Wherefores In Clinical Trials By Major Therapy Area
  • Learning Reasons From Termination Can be Efficient For Companies
  • Recent Changes in Clinical trial guidelines
  • The US Toughens Rules for Clinical Transparency: Investigators are now required to Disclose Even Unsuccessful Trials
  • Recent Changes in Clinical Trials Guidelines in Europe
  • Japan’s New Clinical Research Act will Facilitate Implementation of Clinical Research by Obligating the Researchers
  • Priority Review Has Fast-forwarded The Drug Approval Timelines in Australia
  • Significant Regulatory Changes In China is likely to Accelerate rug Approval Timelines
  • Shortening of IND & NDA Review Has Reduced The Approval Timelines in China

3. Clinical Trial registry

  • Primary National Registries for Clinical Trials
  • Why Do Recruitment Efforts Fail to Enroll Enough Participants?
  • Other Challenges in Clinical Trials
  • Novel Approach For Clinical Trial Design Helps Translate Clinical Trial Evidence To Patient Care

4. Clinical Supply chain Management

  • Meeting Clinical Trials Timelines is Important to Save on Cost
  • Clinical Supply Chain Management (CSCM) Are Helping in Speed Up R&D
  • Key Factors for Efficient Supply Chain Management in Clinical Trials
  • Key Distribution Model in Clinical Supply Chain Management is Best Idea for Executing a Successful Clinical trial
  • Outsourcing For Clinical Trials Resulted In Cost Reduction
  • Clinical Supply Chain – Case Study
  • Outsourcing-A Way towards Discovery And Development Of Drug
  • CRO Activity in 2018 (Q3)

5. Technological Advancement in Clinical Trials

  • Technological Advancement

6. Bibliography

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There has been tremendous innovation over the past decade with the emergence of new drugs with increasing adoption of targeted therapies in the pharmaceutical industry where they invest significant capital and resources into preserving the patient’s life and the subsequent profits of products which take several years to develop. The clinical trial industry has seen a tremendous increase, with major levers to reduce ineffectiveness and safety concerns.

When clinical trials are analyzed by therapy areas oncology is reportedly growing patient load and amidst that oncology is the most widely researched area with emergence of pathways, which go beyond clinical evidence to consider with the continued adoption and development of personalized medicine, immunotherapies, and ultimately cures for cancer.  Hence oncology remains the top therapy area followed by CNS and infectious diseases and henceforth.
 
High economic and social costs of  Diabetes and its rising prevalence make a compelling case for its prevention due to which it remains a top indication in terms of a large number of trials. A varied indications in Oncology, will always attain a higher attention in clinical trial development due to its innovative targets and progressing alternative therapies which will keep Oncology indications at higher pace than others Pain related indication is the second most researched indication  as the understanding of its pathophysiology and molecular level  studies has advanced resulting in a large number of trials. 
 
Phase III trials have the highest duration amongst all phases for design that Phase III must include a long run for finding efficient and safer drug into the market.
 
Asia-Pacific market share has increased for conducting the clinical trial as most Asia has a treatment-naive; skilled investigators; robust clinical infrastructure; faster patient recruitment and lower costs relative to the West; and high-quality output as factors behind the CRO and industry’s growth.
 
In recent times more of a balanced, scientific regulatory, framework for clinical trials has been implemented. These reforms have bought more transparent and economical changes across the globe. Technological advancement and engaging with CRO has helped the pharmaceutical companies to take clinical at a global level and reap the benefits of time and cost saving with proper supply chain management techniques.
 
The disruptive potential of digital technology could drive the most value in the pharmaceutical industry in the future. Pharma companies are planning to start or have already started experimenting with Artificial Intelligence (AI), mobile health (mHealth), Big Data, wearable, internet of things and remote wireless monitoring.

Note: Product cover images may vary from those shown
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