Transgenerational Epigenetics, Second Edition offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with emphasis on human disease relevance, drug discovery, and next steps in clinical translation. Here, international experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease, are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent disease before the offspring are born, or reduce the severity of disease at the very earliest stages of development in utero.
This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as well as current debates and future directions for research.
- Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer- Examines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery- Features chapter contributions from international experts
1. Generational Epigenetic Inheritance
Section I: Definitions, History and Methods of Generational Epigenetic Inheritance 2. Definition of Epigenetic Transgenerational Inheritance and Biological Impacts 3. Historical Perspective of Transgenerational Epigenetics 4. Advances in Genomics and Their Application to Epigenetic Inheritance
Section II: Germline Epigenetics 5. Epigenetics and the Maternal Germline 6. Epigenetic Changes in the Paternal Germline
Section III: Parental Epigenetic Inheritance 7. Maternal Epigenetic Inheritance and Stress During Gestation: Focus on Brain and Behavioral Disorders 8. Paternal Epigenetic Inheritance
Section IV: Epidemiology of Epigenetic Inheritance 9. Epidemiology of Transgenerational Epigenetics
Section V: Basic Mechanisms/Processes of Epigenetic Inheritance 10. Metastable Epialleles 11. Towards the Molecular Mechanisms of Transgenerational Epigenetic Inheritance: Insights from Transgenic Mice 12. Histone-mediated Transgenerational Epigenetics 13. Heritable Generational Epigenetic Effects Through Small Non-coding RNA 14. Long Non-coding RNA and Epigenetic Inheritance
Section VI. Model Organisms 15. Animal Models of Transgenerational Epigenetic Effects 16. Plant Models of Transgenerational Epigenetic Inheritance 17. Epigenetics and Heritable Phenotypic Variations in Livestock 18. Transgenerational Hormonal Imprinting in the Unicellular Tetrahymena
Section VII: Evolution of Transgenerational Epigenetics 19. Evolutionary Perspectives on Transgenerational Epigenetics 20. Inheritance of Epigenome Variants Across Generations and its Implications on the Emergence of Phenotypic Novelties During Evolution
Section VIII: Environmental Epigenetic Effects on the Offspring 21. Transgenerational Epigenetics of Endocrine Disrupting Chemicals 22. Transgenerational Effects of Perinatal Hormonal Imprinting 23. Phenotypic and Epigenetic Inheritance Across Multiple Generations in Mammals Though the Female Line
Section IX: Impact of Transgenerational Epigenetics on Aging and Disease 24. Longevity: The Impact of Epigenetic Inheritance 25. Transgenerational Epigenetic Inheritance of Type 2 Diabetes 26. Epigenetic Transgenerational Inheritance of Reproductive Disease 27. Cardiovascular Disease and Transgenerational Epigenetic Effects 28. Epigenetic Inheritance and Cancer 29. Neuroscience Aspects of Transgenerational Epigenetics
Section X: Clinical Significance of Transgenerational Epigenetics 30. Clinical Aspects of Transgenerational Epigenetics
Section XI: Controversies and Debate of Generational Epigenetic Inheritance 31. Transgenerational Epigenetics: Current Controversies and Debate