Drug Overview
Cimzia (certolizumab; UCB/Astellas [also marketed by Dermira in some approved indications]) is a PEGylated humanized monoclonal antibody fragment, with high affinity for both soluble and membrane-bound tumor necrosis factor alpha. Celltech (now UCB) used its proprietary fragments of antibody (FAb) technology to develop Cimzia for use in chronic inflammatory diseases.
Cimzia was originally approved and launched in the US for the treatment of Crohn’s disease in April 2008. In October 2013, the US Food and Drug Administration approved Cimzia for the treatment of adult patients with active ankylosing spondylitis (AS). In the same month, the drug was granted approval in the EU for the treatment of adults with severe active axial spondyloarthritis, comprising severe active AS and severe active non-radiographic axial spondyloarthritis. Cimzia is also indicated for the treatment of rheumatoid arthritis and psoriatic arthritis.
Cimzia (certolizumab; UCB/Astellas [also marketed by Dermira in some approved indications]) is a PEGylated humanized monoclonal antibody fragment, with high affinity for both soluble and membrane-bound tumor necrosis factor alpha. Celltech (now UCB) used its proprietary fragments of antibody (FAb) technology to develop Cimzia for use in chronic inflammatory diseases.
Cimzia was originally approved and launched in the US for the treatment of Crohn’s disease in April 2008. In October 2013, the US Food and Drug Administration approved Cimzia for the treatment of adult patients with active ankylosing spondylitis (AS). In the same month, the drug was granted approval in the EU for the treatment of adults with severe active axial spondyloarthritis, comprising severe active AS and severe active non-radiographic axial spondyloarthritis. Cimzia is also indicated for the treatment of rheumatoid arthritis and psoriatic arthritis.
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