Drug Overview
Seribantumab (Merrimack Pharmaceuticals) is a monoclonal antibody directed against human epidermal growth factor receptor 3 (HER3), also known as ErbB3. HER3 is a member of the epidermal growth factor receptor family of kinases and is commonly overexpressed in solid tumors, including lung cancer. In particular, seribantumab targets heregulin (HRG)-positive cancer cells, which are characterized by their ability to escape the effects of targeted, cytotoxic, and anti-endocrine therapies. Seribantumab blocks the HRG/HER3 signaling axis in order to make these cells accessible to the effects of these therapies.
Seribantumab (Merrimack Pharmaceuticals) is a monoclonal antibody directed against human epidermal growth factor receptor 3 (HER3), also known as ErbB3. HER3 is a member of the epidermal growth factor receptor family of kinases and is commonly overexpressed in solid tumors, including lung cancer. In particular, seribantumab targets heregulin (HRG)-positive cancer cells, which are characterized by their ability to escape the effects of targeted, cytotoxic, and anti-endocrine therapies. Seribantumab blocks the HRG/HER3 signaling axis in order to make these cells accessible to the effects of these therapies.
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