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Cemiplimab

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    Report

  • 17 Pages
  • August 2018
  • Region: Global
  • Citeline
  • ID: 4775207
Drug Overview
Cemiplimab (Regeneron/Sanofi) is a programmed death-1 (PD-1)-targeted monoclonal antibody. The interaction between PD-1 and its ligand PD-L1 on a T cell reduces T-cell function signals, resulting in tumor cell survival and proliferation due to immune system suppression. The disruption of this interaction reduces the ability of the tumor to evade immune system targeting and enhances antitumor immune responses.

Table of Contents

OVERVIEW
Drug Overview
Product Profiles
cemiplimab : Non-small cell lung cancer (NSCLC)
LIST OF FIGURES
Figure 45: The authors drug assessment summary for Tagrisso in non-small cell lung cancer
Figure 32: The authors drug assessment summary for Imfinzi in non-small cell lung cancer
LIST OF TABLES
Table 1: Cemiplimab drug profile
Table 2: Cemiplimab Phase III trials in non-small cell lung cancer
Table 3: Cemiplimab early-phase data in non-small cell lung cancer
Table 4: Cemiplimab sales for NSCLC across the US, Japan, and five major EU markets, by country ($m), 2017–26
Table 5: Cemiplimab patient numbers for NSCLC across the US, Japan, and five major EU markets, by country, 2017–26
Table 46: Gilotrif patient numbers for NSCLC across the US, Japan, and five major EU markets, by country, 2017–26