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Tafinlar

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    Report

  • 33 Pages
  • August 2018
  • Region: Global
  • Citeline
  • ID: 4775215
Drug Overview
Tafinlar (dabrafenib; Novartis) is an adenosine triphosphate-competitive BRAF inhibitor with more than 100-fold selectivity for mutated BRAF over wild-type. BRAF is part of the mitogen-activated protein kinase (MAPK) signal transduction pathway, which is critical in tumor cell proliferation. The MAPK pathway controls cell proliferation following growth receptor stimulation. The typical binding of the ligand to the receptor triggers a chain of events that includes the activation of a series of downstream effectors, one of these being the RAF series of serine/threonine kinases, including BRAF.

Table of Contents

OVERVIEW
Drug Overview
Product Profiles
Tafinlar : Non-small cell lung cancer (NSCLC)
Tafinlar : Melanoma
LIST OF FIGURES
Figure 1: Tafinlar for non-small cell lung cancer – SWOT analysis
Figure 2: The authors drug assessment summary for Tafinlar in non-small cell lung cancer
Figure 3: The authors drug assessment summary for Tafinlar in non-small cell lung cancer
Figure 4: Tafinlar sales for NSCLC across the US, Japan, and five major EU markets, by country, 2017–26
Figure 5: Tafinlar in melanoma – SWOT analysis
Figure 6: The authors drug assessment summary of Tafinlar for melanoma
Figure 7: The authors drug assessment summary of Tafinlar for melanoma
Figure 8: Tafinlar sales for melanoma across the US, Japan, and five major EU markets, by country, 2017–26
LIST OF TABLES
Table 1: Tafinlar drug profile
Table 2: Mekinist and Tafinlar pivotal trial data in non-small cell lung cancer
Table 3: Tafinlar sales for NSCLC across the US, Japan, and five major EU markets, by country ($m), 2017–26
Table 4: Tafinlar patient numbers for NSCLC across the US, Japan, and five major EU markets, by country, 2017–26
Table 5: Tafinlar drug profile
Table 6: Tafinlar pivotal trial data in melanoma
Table 7: Tafinlar ongoing late-phase clinical trials in melanoma
Table 8: Tafinlar sales for melanoma across the US, Japan, and five major EU markets, by country ($m), 2017–26
Table 9: Tafinlar patient numbers for melanoma across the US, Japan, and five major EU markets, by country, 2017–26