Drug Overview
Tafinlar (dabrafenib; Novartis) is an adenosine triphosphate-competitive BRAF inhibitor with more than 100-fold selectivity for mutated BRAF over wild-type. BRAF is part of the mitogen-activated protein kinase (MAPK) signal transduction pathway, which is critical in tumor cell proliferation. The MAPK pathway controls cell proliferation following growth receptor stimulation. The typical binding of the ligand to the receptor triggers a chain of events that includes the activation of a series of downstream effectors, one of these being the RAF series of serine/threonine kinases, including BRAF.
Tafinlar (dabrafenib; Novartis) is an adenosine triphosphate-competitive BRAF inhibitor with more than 100-fold selectivity for mutated BRAF over wild-type. BRAF is part of the mitogen-activated protein kinase (MAPK) signal transduction pathway, which is critical in tumor cell proliferation. The MAPK pathway controls cell proliferation following growth receptor stimulation. The typical binding of the ligand to the receptor triggers a chain of events that includes the activation of a series of downstream effectors, one of these being the RAF series of serine/threonine kinases, including BRAF.
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