Orkambi

Report
16 Pages
September 2018
Region: Global
Citeline
ID: 4775280

Drug Overview
Orkambi contains the combination of lumacaftor and ivacaftor, which has the dual mechanism of correcting and potentiating the function of CFTR protein, normalizing chloride conductance in patients with cystic fibrosis.

The drug was first approved in the US in July 2015 for the treatment of cystic fibrosis in patients aged 12 years and older with two copies of the F508del mutation, and corresponding EU approval was granted in November 2015.

It is marketed by Vertex alongside Kalydeco, which contains the single CFTR potentiator ivacaftor.

CONTENTS

OVERVIEW

Drug Overview
Product Profiles
Orkambi : Cystic fibrosis

LIST OF FIGURES

Figure 1: Orkambi for cystic fibrosis – SWOT analysis
Figure 2: The authors drug assessment summary of Orkambi for cystic fibrosis
Figure 3: The authors drug assessment summary of Orkambi for cystic fibrosis
Figure 4: Orkambi sales for cystic fibrosis across the US and five major EU markets, by country, 2016–25

LIST OF TABLES

Table 1: Orkambi drug profile
Table 2: Orkambi Phase III data in cystic fibrosis
Table 3: Orkambi sales for cystic fibrosis across the US and five major EU markets, by country ($m), 2016–25

License	Format	Properties	Price
SINGLE USER LICENSE PDF	The product is a PDF.	This is a single user license, allowing one user access to the product.	€9730EUR$10,000USD£8,335GBP
ENTERPRISE LICENSE PDF	The product is a PDF.	This is an enterprise license, allowing all employees within your organization access to the product.	€47676EUR$49,000USD£40,842GBP

Table of Contents

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