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Ozanimod

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    Report

  • 34 Pages
  • August 2018
  • Region: Global
  • Citeline
  • ID: 4775307
Drug Overview
Ozanimod (Celgene) is a sphingosine 1-phosphate (S1P) receptor agonist, with selectivity for the sphingosine 1-phosphate type 1 receptor (S1P1) and sphingosine 1-phosphate receptor 5 (S1P5).

The drug modulates the expression of S1P receptors, which is thought to reduce the overall number of circulating lymphocytes by preventing their migration from secondary lymphoid organs.

The drug is being developed in multiple sclerosis, ulcerative colitis, and Crohn’s disease.

Table of Contents

OVERVIEW
Drug Overview
Product Profiles
ozanimod: Crohn's disease
ozanimod: Multiple sclerosis
ozanimod: Ulcerative colitis
LIST OF FIGURES
Figure 29: The authors drug assessment summary of etrolizumab in Crohn’s disease
Figure 6: The authors drug assessment summary of filgotinib in Crohn’s disease
Figure 23: The authors drug assessment summary of Stelara in Crohn’s disease
Figure 23: The authors drug assessment summary of Stelara in Crohn’s disease
Figure 31: Etrolizumab for Crohn’s disease – SWOT analysis
Figure 34: Ozanimod for Crohn’s disease – SWOT analysis
Figure 6: The authors drug assessment summary of ozanimod in Crohn’s disease
Figure 27: Tysabri sales for Crohn’s disease in the US, 2016–25
LIST OF TABLES
Table 1: Ozanimod drug profile
Table 2: Ozanimod Phase III trials in Crohn’s disease
Table 3: Ozanimod Phase II data in Crohn’s disease
Table 4: Ozanimod drug profile
Table 28: Tysabri pivotal trial data in Crohn’s disease
Table 6: Ozanimod sales for multiple sclerosis across the US and five major EU markets, by country, 2016–25
Table 7: Ozanimod drug profile