A Large and Rapidly Growing Market for Stem Cells Research Products has Emerged
Stem cells are primitive cells found in all multi-cellular organisms that are characterized by self-renewal and the capacity to differentiate into mature cell types.
Several broad categories of stem cells exist, including:
- Embryonic stem cells, derived from blastocysts
- Perinatal stem cells, obtained during the period immediately before and after birth
- Adult stem cells, found in adult tissues
- Induced pluripotent stem cells, produced by genetically reprogramming adults cells
- Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body
Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. In addition, their “unspecialized” nature allows them to differentiate into a wide variety of specialized cell types. In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult organisms, stem and progenitor cells act as a repair system for the body, replenishing specialized cells.
The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease to cell therapy, tissue regeneration, bioprinting, drug discovery, toxicology testing, and more. Of interest to clinical researchers is the potential to use stem cells within regenerative medicine, and the pharmaceutical industry is integrating stem cells to conduct pharmacological testing on cell-specific tissues. There is also demand for extracellular vesicles (EVs) derived from stem cells because they can act as intercellular messengers and may be able to exert some types of therapeutic effects.
Traditionally, scientists have worked with both embryonic and adult stem cells as research tools. While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral, and spiritual controversy surrounding their use for research purposes. Although some adult stem cells do have differentiation capacity, it is often limited in nature, which results in fewer options for use. Thus, when induced pluripotent stem cells (iPSCs) were discovered in 2006 by Shinya Yamanaka of Kyoto University in Japan, they represented a promising combination of adult and embryonic stem cell characteristics.
iPSCs are adult cells that are isolated and then transformed into embryonic-like stem cells through the manipulation of gene expression and other methods. The first successful generation of iPSCs was via research and experimentation using mouse cells at Kyoto University in Japan. In 2007, a series of follow-up experiments were done at Kyoto University in which human adult cells were transformed into iPSC cells. Nearly simultaneously, a research group led by James Thomson at the University of Wisconsin-Madison accomplished the same feat of deriving iPSC lines from human somatic cells.
To facilitate research resulting from an interest in these far-ranging applications, a large and rapidly growing market for stem cell research products has emerged. Today, well over one-hundred companies produce products to support the activities of stem cell scientists worldwide. The tools commercialized by these companies include ones to isolate, expand, culture, differentiate, and characterize stem cells, as well as technologies to enable their production at any scale.
Broad categories of stem cell research products include, but are not limited to:
- Stem cell lines (such as iPSCs, MSCs, HSCs, NSCs, and ESCs)
- Stem cell culture media with supplements
- Consumables (such as antibodies, consumables in assays, cryoprotective agents and microcarriers)
- Instruments (such as freezers, bioreactors, cytometry devices, and assay systems)
- Stem cell services
Specifically, the following compose the majority of stem cell product sales:
- Primary antibodies to stem cell antigens
- Bead-based stem cell separation systems
- Fluorescent-based labeling and detection
- Stem cell protein purification and analysis tools
- Tools for DNA and RNA-based characterization of stem cells
- Isolation/characterization services
- Stem cell culture media and reagents
- Stem cell-specific growth factors and cytokines
- Tools for stem cell gene regulation
- Mechanisms for in vivo and in vitro stem cell tracking
- Expansion/differentiation services for stem cell media and RNAi
- Stem cell lines
- Done-for-you or done-with-you services
With market competition growing increasingly fierce, ten of the largest companies selling stem cell research products are:
- Thermo Fisher Scientific
- BD Biosciences, a Division of Becton Dickinson (BD)
- Merck KGaA
- Miltenyi Biotec
- STEMCELL Technologies
- Lonza Group
- Takara Bio
- GE Healthcare Life Sciences
- FUJIFILM CDI
- Sigma Aldrich
Furthermore, there are many specialty vendors of stem cell research products, such as FUJIFILM CDI, ReproCELL and Ncardia (who specialize in iPSC-related products), RoosterBio (who specializes in human MSC-specific products), and Corning (who specializes in Matrigel products to support pluripotent stem cell culture and culture-ware), for example.
Key report findings include:
- Stem cell research applications, including priorities by segment
- The relative demand for stem cell products, by stem cell type
- Analysis of stem cell manufacturing technologies, including costs, risks, and the rise of contract manufacturing organizations (CMOs)
- Analysis of market trends, including opportunities and threats
- Competitive analysis for 128 market participants composing the global market
- Market size determination, including detailed segmentation and 5-year projections
Input Sources
The content and statistics contained in this report were compiled using a broad range of sources. These input sources include:
- Interviews with Stem Cell Executives, completed by the publisher’s Founder and Analysts
- Stem Cell Grant Funding Database (Report Database, CIRM, MRC, Wellcome Trust - UK)
- Stem Cell Patent Database (United States Patent and Trade Office, World Intellectual Property Organization)
- Stem Cell Clinical Trial Database (ClinicalTrials.gov, International Clinical Trials Registry Platform, European Union Clinical Trials Register)
- Stem Cell Scientific Publication Database (PubMed, Highwire Press, Google Scholar)
- Stem Cell Product Launch Announcements (Trade Journals, Google News)
- Stem Cell Industry Events (Google News, Google Alerts)
- Stem Cell Company News (SEC Filings, Investor Publications, Historic Performance)
- Social Analytics Platforms (Google Trends, Google Adwords, BuzzSumo)
- And More
The possibilities arising from stem cells have resulted in great commercial interest. The purpose of this report is to reveal market dynamics affecting basic and translational research, clinical and commercial applications, and the rising demand for stem cell research products on a global basis. Importantly, it unveils the identities of leading market competitors and presents a market size breakdown, including detailed segmentation with 5-year projections. Use it to identify emerging market opportunities, spot new product development opportunities before your competition, and make smarter decisions, faster.
Table of Contents
Companies Mentioned
- 3D Biotek LLC
- Abbexa Ltd.
- ABclonal
- Abeomics Inc.
- Abnova
- Absolute Antibody Ltd.
- Agilent Technologies Inc.
- Alomone Labs Ltd.
- AmProtein - China Inc.
- Antigenix America Inc.
- Apceth Biopharma GmbH
- Applikon Biotechnology BV
- AS ONE INTERNATIONAL, INC.
- Assaypro
- ATCC
- Athersys, Inc.
- Atlas Antibodies AB
- ATVIO Biotech, Ltd.
- Aviva Systems Biology Corp.
- Becton, Dickinson and Company
- Bio Basic
- Bio X Cell
- Bio-Rad Laboratories, Inc.
- BioIVT
- BioLegend
- BioLife Solutions Inc.
- Biorbyt Ltd.
- BioSperix Ltd.
- Bioss Antibodies Inc
- BioVendor - Laboratorni Medicina A.S
- BioVision Inc.
- Bon Opus Biosciences
- BosterBio
- CEDARLANE
- Cell Culture Technologies LLC
- Cell Microsystems Inc.
- Cell Signaling Technology Inc.
- Cellexus Ltd.
- Celltainer Biotech
- ChromoTek GmbH
- Cognate BioServices Inc.
- Corning Life Sciences
- CUSABIO Technology LLC
- Cygnus Technologies
- Diagenode SA
- DWK Life Sciences
- EMD Millipore Corp.
- enQuire BioReagents
- Enzo Lifesciences Inc.
- EpiGentek Group Inc.
- Eppendorf AG
- Eurogentec, S.A.
- EXBIO Praha a.s
- FabGennix International Inc.
- Fitzgerald Industries International
- GE Healthcare Bio-Sciences
- GeneTex Inc.
- GenScript
- Greiner Bio-One International GmbH
- HemaCare Corporation
- HiMedia Laboratories
- HuaBio
- Hycult Biotech
- HyTest Ltd.
- ImmuQuest Ltd.
- InSphero AG
- Invent Biotechnologies Inc.
- InvivoGen
- Irvine Scientific, Inc. (FUJIFILM Irvine Scientific, Inc.)
- iXCells Biotechnologies
- Kerafast, Inc.
- LifeSpan BioSciences Inc.
- Lonza AG
- Maine Biotechnology Services (BBI Group)
- MaSTherCell S.A.
- MBL International
- MD Biosciences (Bioproducts Division)
- Miltenyi Biotec GmbH
- Minerva Biotechnologies Corporation
- Monash Antibody Technologies Facility (MATF)
- MP Biomedicals LLC
- MyBioSource Inc.
- Ncardia AG
- New England Biolabs
- Novasep Holding SAS
- NovaTeinBio
- Novus Biologicals
- NSJ Bioreagents
- Octane
- PBS Biotech Inc.
- PROGEN
- PromoCell GmbH
- ProSci Inc.
- Proteintech Group Inc.
- ProteoGenix
- QED Bioscience Inc.
- R & D Systems
- Ray Biotech
- Reddot Biotech Inc
- REPROCELL Inc.
- Rev MAb Biosciences
- RoosterBio, Inc.
- RoslinCT
- SAFC Biosciences Inc.
- Santa Cruz Biotechnology Inc.
- Sartorius AG
- ScienCell Research Laboratories
- Shanghai Korain Biotech Co., Ltd.
- Sigma-Aldrich Corp.
- Signalway Antibody LLC
- Sino Biological Inc.
- SouthernBiotech
- StemBioSys, Inc.
- STEMCELL Technologies.
- Synaptic Systems GmbH
- Synthecon Inc.
- Takara Bio Inc.
- Terumo BCT Inc.
- Thermo Fisher Scientific Inc
- United States Biological
- Vitrolife AB
- VWR International LLC
- Wuxi Donglin Sci & Tech Development Co. Ltd.
- Xcellerex (GE Healthcare)
- YposKesi, SAS (Genethon)
- Zellwerk GmbH
- Zen-Bio, Inc.
Methodology
The content and statistics contained within the publisher's reports are compiled using a broad range of sources, as described below.
Input Sources
- Clinical Trial Databases (ClinicalTrials.gov, International Clinical Trials Registry Platform, European Union Clinical Trials Register, Chinese Clinical Trial Registry, Others)
- Scientific Publication Databases (PubMed, Highwire Press, Google Scholar)
- Patent Databases (United States Patent and Trade Office, World Intellectual Property Organization, Google Patent Search)
- Grant Funding Databases (RePORT Database, CIRM, MRC, Wellcome Trust - UK, Others)
- Product Launch Announcements (Trade Journals, Google News)
- Industry Events (Google News, Google Alerts, Press Releases)
- Company News (SEC Filings, Investor Publications, Historical Performance)
- Social Analytics (Google Adwords, Google Trends, Twitter, Topsy.com, Hashtagify.me, BuzzSumo.com)
- Interviews with Stem Cell Industry Leaders
Research & Analysis Methodologies
The publisher employs the following techniques for deriving its market research:
- Historical Databases: As the first and only market research firm to specialize in the stem cell industry, the publisher has 13+ years of historical data on each segment of the stem cell the industry. This provides an extremely rare and robust database for establishing market size determinations, as well as making future market predictions.
- Prolific Interviews with Industry Leaders: As the global leader in stem cell industry data, the publisher has interviewed hundreds of leaders from across the stem cell industry, including the CEO of FUJIFILM CDI, FUJIFILM Irvine Scientific, Pluristem Therapies, Celularity, and many others.
- Industry Relationships: The research team and its President/Founder, Cade Hildreth, Chair and present at a wide range of stem cell industry events, including Phacilitate's Advanced Therapies Week, World Stem Cell Summit (WSCS), Perinatal Stem Cell Society Congress, AABB's International Cord Blood Symposium (ICBS), and other events hosted within the U.S. and worldwide.
- Global Integrated Feedback: Because the publisher maintains the world's largest stem cell industry news site that is read by nearly a million unique readers per year and the company has large social media audiences (25.7K+ followers on Linked, 21.2K+ followers on Twitter, and 4.3K+ followers on Facebook), the publisher is able to publish content relevant to the industry and receive immediate feedback/input from a global community of readers. In short, the publisher's data is crowd-sourced from market participants worldwide, including those in diverse geographic regions.
- Preliminary Research: In addition to the interviews described above, the publisher conducts market surveys, executes social media polls, and aggregates market data from stem cell industry announcements, press releases, and corporate filings/presentations.
- Secondary Research: The publisher summarizes, collects and synthesizes existing market research that is relevant to the market area of interest.
- Future Projections: Using the resources described above, the publisher is uniquely positioned to make future projections about market size, market growth by segment, market trends, technology evolution, funding activities (financing rounds, M&A, and IPOs), and importantly, market leadership (market share by company).
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