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3D Cell Cultures: Technologies and Global Markets

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    Report

  • 442 Pages
  • February 2024
  • Region: Global
  • BCC Research
  • ID: 5129922

This report aims to provide a comprehensive study of the global 3D cell culture technologies market. It provides a detailed description of the different types of healthcare interoperability solutions and their current and historical market revenues.



The scope of the report encompasses the major types of 3D cell culture which are being used by industry, academic researchers, government labs, and independent research groups. This includes the main inputs such as cell lines, media, sera, reagents, software, and instrumentation. It analyzes the current market status, examines future market drivers and presents forecasts of growth over the next five years.

The market structure has been reorganized for this edition. Also, more research was done on base case data for different product areas. The greater emphasis is on the different products used for 3D cell culture, but the report also investigates the market in terms of types of applications, end users and geographic regions.

Report Includes

  • 17 data tables and 105 additional tables
  • An overview of the global market landscape related to the 3D cell cultures technologies
  • In-depth analysis of global market trends, featuring historical revenue data for 2020-2022, estimated figures for 2023, as well as forecasts for 2028. This analysis includes projections of Compound Annual Growth Rates (CAGRs) spanning through 2028
  • Evaluation of the current market size and revenue growth prospects specific to 3D cell cultures technologies, accompanied by a comprehensive market share analysis categorized by type, end user, and geographical region
  • Information on analytical systems used in tissue and cell culture, cellomics, and human cancer model initiative (HCMI)
  • Details about assay development for mesenchymal stem cells, In Vitro testing of adventitious agents and description of assays and assay kits
  • A look at the main classes of models for researching cancer and other diseases, benefits of 3D models to cancer research and description of 3D engineered scaffolds
  • Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities and discussion on the impact of COVID-19 on the world of cell culture
  • Insights into U.S. regulatory status of bioprinted products; basic guidance for the regulation of biologics, regenerative medicine and xenotransplants
  • Relevant patent analysis, including recent activity and a list of key patents
  • Detailed profiles of leading market participants, providing a descriptive overview of their respective businesses, including Abcam PLC, Agilent Technologies Inc., Corning Inc., Merck KGAA, Beckman Coulter, and Synvivo Inc.

Table of Contents

Chapter 1 Introduction
  • Study Goals and Objectives
  • Reasons for Doing the Study
  • Scope of Report
  • What's New in This Report?
  • Methodology and Information Sources
  • Geographic Breakdown
  • Segment Breakdown
Chapter 2 Summary and Highlights
  • Market Outlook
  • Market Summary
Chapter 3 Market Overview
  • An Opening Comment on an Amazing Industry
  • Industry Issues
  • In Vitro versus In Vivo
  • Dimensionality
  • The Research Chain for 2D and 3D Cell Culture
  • Best Practices
  • Standardization
  • Regulation
  • Genomics Forcing the Hand of the FDA
  • Leachables and Extractables
  • Broad Issues
  • Research Talent Shortages
  • The Shifting International Picture
  • Pace and Diversification of Innovation
  • A Comment on the "Other" Areas of Cell Culture
  • Omics Everywhere
  • Is 2020 a Watershed Year for the Cell Culture Industry?
  • Preliminary Market Analysis
  • Cell Culture Market Growth Rate Estimates
  • Assessing Large-Scale Media Consumption Needs
  • Modeling Future Growth in Biopharmaceuticals
  • Base Case for the Cell Culture Market
  • Challenges in Projecting Sales and Growth
  • Cell Culture Media Market Estimates
  • Cell and Gene Therapy Bioprocessing Segment
  • Evaluating Media Consumption for Biosimilars
  • What About CDMOs?
  • Microfluidics
  • Bioreactors
  • Internal Cell Culture Resources
  • Is There Too Much Concentration of Ownership in Biotechnology?
  • Characterizing Innovation in 3D Cell Culture
  • Bioprinting Strategic Roadmap
Chapter 4 Market, by Type
  • Where Did Tissue and Cell Culture Start?
  • History and Early Applications
  • Invention of Tissue Culture
  • Development of Sustained Cell Lines
  • First Cell Culture Flask and Rigorous Techniques
  • Lindbergh: The Cell Culture Equipment Pioneer
  • Establishing Continuous Cell Lines
  • Key Developments in Equipment
  • Terminology and Concepts
  • Tissue and Cell Culture Industry
  • Tissue Culture and Cell Culture Definitions
  • Cell Lines
  • Care and Growth of Cell Culture Systems
  • Media, Sera, and Reagents
  • Gels and Scaffolds
  • Microplates/Microtiter Plates
  • Bioanalytical Instruments
  • Bioanalytical Imaging
  • Bioprinting
  • Bioreactors
  • Other Equipment for Cell Culture
  • Adherent Approaches
  • Traditional Roller Bottles
  • Other Systems
  • Information Technology: Software and Services for the Cell Culture Research Market
  • Software for the Research Market in Cell Culture
  • Software-Related Support Services
  • Bioprocessing Consumables for Cell Culture
  • Microcarriers for Large-Scale 3D Culture
  • Sera for Large-Scale 3D Culture
  • Media for Large-Scale 3D Culture
  • Bioreactor Bags for Large-Scale 3D Culture
  • Other
  • Bioprocessing Equipment
  • Analytical Equipment for Bioprocessing
  • Automation Systems for Bioprocessing
  • Support Equipment for Bioprocessing
  • Aspects of Large-Scale Manufacturing of Biopharmaceuticals and Vaccines
  • Suspension Proteins and Monoclonal Antibodies
  • Adherent-Cell-Based Therapies and Vaccines
  • Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues
  • Vaccines
  • Vaccine Development as a Catalyst
  • Vaccines Developed Using Human Cell Strains
  • Exosome Manufacturing
  • Viral Vector Manufacturing
  • Lentivirus Manufacturing
  • Plasmid Manufacturing
  • Cell Culture End Users
  • Pharma/Biopharma
  • Universities
  • Government
  • CROs/CDMOS
  • Other
  • Cell Culture Applications
  • Drug Discovery
  • Clinical Development
  • Toxicology
  • Basic Research
  • Bioprocessing Development
  • Other
  • Regional Markets
  • The Americas
  • Europe
  • Asia-Pacific
  • Rest of the World
Chapter 5 Assays, Imaging and Analysis
  • Assays
  • Assay Development for Mesenchymal Stem Cells
  • In Vitro Testing of Adventitious Agents
  • Assays and Assay Kits
  • Cell-Based Assays: Overview and Newer Developments
  • Cells Used in Cell-Based Assays
  • Notes on 3D Cell-Based Assays
  • Kinetic Metabolism Assays
  • Cell Proliferation
  • Viability and Cytotoxicity
  • Permeability Assays for Cell Viability and Survival
  • Cell Invasion
  • Cell Signaling and Communication
  • Cytostatic
  • Cell Death Assays
  • Imaging Technology
  • Imaging Assays
  • Fluorescence as a Driver of Screening
  • Analytical Systems Used in Tissue and Cell Culture
  • Understanding "Cellomics"
  • HCS Support of 3D Cell Culture
  • NGS Discovery Pools
  • Multiplex Assays
  • Predictive Toxicology
  • Neuro Safety
  • The Omics Invasion
  • Transcriptomics
Chapter 6 Regulation and Standardization
  • U.S. Regulatory Status of Bioprinted Products
  • Basic Guidance for the Regulation of Biologics
  • Guidance for Regenerative Medicine
  • Guidance for Xenotransplants
  • Guidance for Regenerative Medicine: Emergency Approval
  • Regulating Bioprinted Products
Chapter 7 3D Models for Cancer
  • Disease Modeling
  • Cancer
  • Main Classes of Models for Researching Cancer and Other Diseases
  • Cell Lines
  • Spheroids and Organoids
  • Genetically Engineered Mouse Model (GEMM)
  • Patient-Derived Tumor Xenografts (PDXs)
  • Overview: Cancer at the Cellular Level
  • In Vivo (Animal) Testing Standard
  • Empire of the Mouse
  • Humanized Mice
  • 2D Culture
  • 3D Requirements
  • Cell Number and Viability
  • Migration and Invasion
  • Unmet Needs: Angiogenesis and Immune System Evasion
  • Benefits of 3D Models to Cancer Research
  • Greater Distinction in Cell Morphology and Proliferation
  • Greater Gene Expression and Cell Behavior
  • Better Models of Cell Migration and Invasion
  • Cell Heterogeneity
  • Breast Cancer as a Driver of 3D Cultures
  • Structure, Polarity and Apoptosis
  • Melanoma as a Driver of 3D Cultures
  • Moving to Spheroid Configurations
  • 3D Systems in Cancer Research
  • Multicellular Tumor Spheroids
  • Multilayered Cell Cultures
  • 3D Engineered Scaffolds
  • Natural Materials
  • Synthetic Materials
  • Human Cancer Model Initiative (HCMI)
  • Next-Generation Human Cancer Models
  • Drug Sensitivity and Resistance
  • Altered Signaling and Sensitivity
  • Drug Resistance
  • Cellular Signaling
  • Cellular Signaling Mediated by Integrins
  • Drug Screening
  • Approaches and Endpoints
  • Spheroid Applications
  • Metastasis via 3D Cell Migration Model
  • Metastasis via Lung-on-Chip
  • Cancer Metabolism
  • Future Horizons
  • Metastases
  • Co-culture
  • Vascularization
  • Cancer-Associated Fibroblasts
  • Cancer Stem Cells
  • Combination Therapies
  • Biologics Development
  • Tumor Recurrence
  • Patient-Derived Cells
  • Patient-Derived Tumor Xenografts (PDXs)
  • Evolution of PDX Platforms
Chapter 8 Landscape for Toxicology and Drug Safety Testing
  • Introduction
  • Liver
  • Toxicology Background
  • Testing for Adverse Effects on the Skin
  • New Assessment Methodologies Impact on 3D Cell Culture
  • Toxicology Testing in Cosmetics
  • Updated Regulatory Requirements
  • Efficacy of Cosmetics and Cosmeceuticals
  • Aspects of Cosmetic Toxicity Testing
  • Skin Irritation
  • Skin Corrosion
  • Phototoxicity
  • Skin Sensitization
  • Eye Irritation
  • Acute Systemic Toxicity
  • Acute Toxicity Testing
  • Cytotoxicity Assays for Acute Toxicity Testing
  • Chronic and Repeated Dose Toxicity
  • Carcinogenicity and Genotoxicity
  • Overview
  • In Vitro Methods: Background and Recent Developments
  • Regulatory versus Drug Development Applications
  • Efforts to Reduce False Positives
  • Recent Innovations in Screening
  • Future Challenge: Non-genotoxic Carcinogens
  • Reproductive and Developmental Toxicity
  • Background
  • Following the Reproductive Cycle
  • Development and Reproductive Tox Testing Types
  • Zebrafish Model for Developmental Toxicity Screening
  • Combination of Zebrafish and Stem Cells
  • Biomedical Frontiers: Male Testis
  • Endocrine Disruptor Screening
  • Background
  • Environmental Toxicology Impacts In Vitro Methods
  • ToxCast and Tox 21 Initiatives
  • Future Challenge: Thyroid Disruption
  • BG1 Assay
  • Toxicokinetics and ADME
  • In Vitro Developments
  • Metabolism
  • Pharmacokinetics of Low-Turnover Compounds
  • Organotypic Models
  • 3D Models for Skin
  • 3D Corneal System
  • Absorption Barrier Models
  • Gastrointestinal
  • Lung
  • Blood-Brain Barrier
  • Real Architecture for 3D Tissue Barriers and Extracellular Matrix
  • Liver Toxicity
  • Uniqueness and Complexity of Liver
  • Liver as a Key Driver for 3D Innovation
  • In Vitro Liver Applications
  • In Vivo Liver Function and Structure
  • Liver Metabolism
  • In Vitro Liver Models
  • Co-cultures of Hepatocytes and Macrophages
  • 3D Liver Models
  • Bioprinted Liver Tissue
  • Detected Hepatosphere Structures and Functionality
  • Ideal Criteria
  • Drug Resistance
  • Transporter Studies
  • Achieving Heterotypic Cell-Cell Contacts
  • Unmet Needs and Future Drivers of Innovation
  • Morphogen Signaling
  • Multi-donor Liver Cells
  • Kidney Toxicity Applications
  • Future Challenge: Stem-Cell Derived Kidney Cells
  • Bioprinted Kidney Tissue
  • Pancreatic Toxicology Applications
  • Cardiovascular Toxicity
  • Commercial Avenue
  • Collaboration with Regulators
  • Cardiovascular Drug Discovery
  • Microelectrode Arrays (MEAs) Based on Impedance
  • Surrogate for Aortic Ring Assay via Bioprinted Magnetics
  • Vasodilator Activity
  • 3D Engineered Heart Tissues
Chapter 9 Market Breakdown by Region
  • Introduction
  • North America
  • United States
  • Canada
  • Europe
  • Germany
  • United Kingdom
  • Asia-Pacific
  • China
  • Japan
  • India
  • South Korea
  • Singapore
  • Rest of the World
Chapter 10 Stem Cell Landscape
  • A History of Stem Cells
  • Major and Minor Research Areas for Stem Cells
  • 3D Stem Cell Culture Systems
  • Plate or Culture Dish
  • Spinner Flask and Rotating Wall Vessel
  • Perfusion Bioreactor and Microcarrier Systems
  • Shortcomings
  • Microfluidics and Stem Cells
  • Short Review of Stem Cell Biology
  • Embryogenesis
  • Growth, Structure and Morphology of Stem Cells
  • Stem Cell Differentiation
  • Stem Cell Differentiation versus Proliferation
  • Extracellular Matrix and Stem Cells
  • Soluble Factors
  • Manufacturing Stem Cells
  • Controlling Embryoid Body Formation
  • Forced Aggregation Cultures
  • Hanging-Drop Approach
  • Applications
  • Stem Cell Markers for High-Throughput Screening
  • Teratomas and the Teratoma Assay
  • Fujifilm (Cellular Dynamics Inc.)
  • Stem Cell Research Breakthroughs
  • Stem Cells for Neuroscience Discovery and Development
  • Example: Alzheimer's Research
  • Background: B-Amyloid Cascade Hypothesis
  • Human iPSC-Derived Models
  • New 3D Model
  • Other Advantages of 3D
  • Envisioned Applications
  • Other 3D Neuro Applications
  • Stem Cells for Cardiovascular Discovery
  • Stem Cells for the Development of Regenerative Medicine
  • Background: Allogenic versus Autologous
  • MicroRNAs
  • Induced Pluripotent Stem Cells (IPS)
Chapter 11 Regenerative Medicine: Organ Transplants and Skin Substitutes
  • Regenerative Medicine
  • Need for Organ Transplants
  • Applications in Regenerative Medicine
  • Investments in Regenerative Medicine
  • Skin Substitutes Industry
  • Tissue Culture Allograft and Autograft Products
  • Tissue Engineering in Regenerative Medicine
Chapter 12 Company Profiles
  • 3D BIOPRINTING SOLUTIONS
  • 3D BIOTEK LLC
  • 4D TECHNOLOGY CORP.
  • ABCAM PLC
  • AKRON BIOTECH
  • AGILENT TECHNOLOGIES INC.
  • ALPCO
  • AMSBIO
  • BECKMAN COULTER INC.
  • BIOINSPIRED SOLUTIONS
  • BIOTIME INC.
  • BIOVISION INC.
  • CELL APPLICATIONS INC.
  • CELLINK
  • CORNING INC.
  • CYPROTEX
  • CYTIVA
  • CYTOO SA
  • EMD MILLIPORE / MERCK KGAA
  • EMULATE INC.
  • ENVISIONTEC INC.
  • EPITHELIX
  • EUROFINS SAS
  • GREINER BIO-ONE INTERNATIONAL GMBH
  • HAMILTON ROBOTICS
  • HUB ORGANOIDS
  • HUREL CORP.
  • INSPHERO
  • INVITROCUE
  • KIYATEC INC.
  • LIFENET HEALTH
  • LOREM VASCULAR / CYTORI THERAPEUTICS INC.
  • MATTEK
  • MIMETAS INC.
  • ORGANOVO HOLDINGS INC.
  • PERKINELMER INC.
  • PLASTICELL LTD.
  • PLURISTEM THERAPEUTICS INC.
  • POIETIS
  • PROMEGA CORP.
  • SEAHORSE BIOSCIENCE
  • STEMCELL TECHNOLOGIES
  • STRATATECH CORP.
  • SYNVIVO INC.
  • TAP BIOSYSTEMS
  • TECAN TRADING AG
  • ZEN-BIO INC.
List of Tables
Summary Table: Global Market for 3D Cell Culture, by Segment, Through 2028
Table 1: Dimensionality of Cell Culture
Table 2: WHO R&D Roadmap of Priority Infectious Diseases
Table 3: 3D Bioprinting Roadmap
Table 4: Selected Online Prices for Bioreactors
Table 5: Global Market for 3D Cell Culture, by Segment, Through 2028
Table 6: Tissue Types
Table 7: Cell Types Based on Developmental Origin
Table 8: Leading Cell Line Suppliers, April 2020
Table 9: Commonly Used Transformed Cells Lines
Table 10: Major Primary Cell Lines
Table 11: Leading Primary Cell Suppliers
Table 12: Main Types of Stem Cells
Table 13: Stem Cell Services
Table 14: Areas of Interest in 3D Spheroid Research
Table 15: Selected Nanoparticle Products Used in Life Science Research
Table 16: Results of Liver-Chip Drugs Halted in Previous Clinical Trials Based on Animal Studies
Table 17: Companies and Universities Involved in the Organ-on-a-Chip Industry
Table 18: Microfluidics Companies
Table 19: Selected Recent Patents Issued on Microfluidic Devices Related to Cell Culture Applications
Table 20: Selected Papers Published on Recent Microfluidic Advances in Cell Culture
Table 21: High-Content Screening Suppliers and Key Attributes
Table 22: Selected Patents Issued Related to Flow Cytometers
Table 23: Thermo Fisher Imaging Products
Table 24: Recent Bioprinting Company Deals and Strategic Partnerships
Table 25: Bioprinting Modalities
Table 26: Maintaining Cell Viability During Printing
Table 27: Bioprinting Instrument Industry
Table 28: Biomaterial Components
Table 29: Bioink Types
Table 30: Classes of Matrix Bioink Hydrogels
Table 31: Matrix Bioink Selection Criteria
Table 32: Selected Bioink Companies, 2020
Table 33: Projected Unit Sales of Research Bioreactors, < 10 Liters, 2020
Table 34: Leading Bioreactor Suppliers, 2020
Table 35: Label-Free Technologies and Suppliers
Table 36: Developmental Issues Facing the Commercialization of Exosomes
Table 37: Companies Working on Exosome Products
Table 38: Global Market for Cell Culture, by End User, Through 2028
Table 39: Global Market for Cell Culture, by Application, Through 2028
Table 40: Global Market for Cell Culture, by Region, Through 2028
Table 41: Typical Assay Endpoints and Tests
Table 42: U.S. Patents on Assays Systems, 2019 and 2020
Table 43: Selected U.S. Patents on Assay Imaging, 2019 and 2020
Table 44: Recently Issued U.S. Patents on Cellomics, 2019
Table 45: Toxicology Issues That Need to Be Addressed for FDA-Regulated Products
Table 46: Overview of Federal Regulation of the Cell Culture Markets
Table 47: FDA List of Cell, Biologic and Tissue Products Regulated Under CBER and CDRH
Table 48: FDA “Talking Point” Recommendations for Regenerative Medicine Advanced Therapies (RMATs)
Table 49: U.S. Regulatory Considerations for Bioprinted Biologics
Table 50: Main Types of Models for Researching Cancer and Other Diseases
Table 51: Goals of Funding Opportunity Announcement RFA-CA-19-055
Table 52: Common 3D Assays
Table 53: Summary of the Benefits and Advantages of EV3D
Table 54: ECVAM List of Current Activities, 2020
Table 55: In Vitro Testing in Cosmetics, by Test Class
Table 56: Global Market for Cell Culture by Region, Through 2028
Table 57: North American Market for Cell Culture by Country, Through 2028
Table 58: European Market for Cell Culture by Country, Through 2028
Table 59: Asia-Pacific Market for Cell Culture by Country, Through 2028
Table 60: RoW Market for Cell Culture by Region, Through 2028
Table 61: Major and Minor Research Areas in Stem Cells
Table 62: Stem Cell Usage in Research
Table 63: Recent U.S. Patents Granted on Stem Cell Technologies
Table 64: Papers Published on Selected Stem Cell Research Trends
Table 65: Comparison of the Number of Citations in the Literature on Cell Culture versus Stem Cell Culture
Table 66: Number of Organ Transplants Performed in the United States, 2018 and 2019
Table 67: Total Global Financing of Regenerative Medicine
Table 68: Total Financing of Regenerative Medicine, by Therapeutic Area
Table 69: Leading Tissue Products and Suppliers
Table 70: Printed Tissue and Organs: Commercialization Timeframe
Table 71: Tissue/Organ Complexity
Table 72: 3D Bioprinting Solutions: Company Snapshot
Table 73: 3D Biotek LLC: Company Snapshot
Table 74: 4D Technology Corp.: Company Snapshot
Table 75: Abcam Plc: Company Snapshot
Table 76: Abcam PLC: Financial Performance, 2022
Table 77: Akron Biotech: Company Snapshot
Table 78: Agilent Technologies: Company Snapshot
Table 79: Agilent Technologies Inc.: Financial Performance, 2022
Table 80: Alpco: Company Snapshot
Table 81: Amsbio: Company Snapshot
Table 82: Beckman Coulter: Company Snapshot
Table 83: Bioinspired Solutions: Company Snapshot
Table 84: BioTime Inc.: Company Snapshot
Table 85: Biovision Inc.: Company Snapshot
Table 86: Cell Applications Inc.: Company Snapshot
Table 87: Cellink: Company Snapshot
Table 88: Corning Inc.: Company Snapshot
Table 89: Corning Inc.: Financial Performance, 2022
Table 90: Cyprotex: Company Snapshot
Table 91: Cytiva: Company Snapshot
Table 92: Cytoo SA: Company Snapshot
Table 93: Merck KGAA: Company Snapshot
Table 94: Merck KGAA: Financial Performance, 2022
Table 95: Emulate Inc.: Company Snapshot
Table 96: EnvisionTec Inc.: Company Snapshot
Table 97: Epithelix: Company Snapshot
Table 98: Greiner Bio-One International GmbH: Company Snapshot
Table 99: Hamilton Robotics: Company Snapshot
Table 100: HUB Organoids: Company Snapshot
Table 101: Hurel Corp.: Company Snapshot
Table 102: Insphero: Company Snapshot
Table 103: Invitrocue: Company Snapshot
Table 104: Kiyatec Inc.: Company Snapshot
Table 105: LifeNet Health: Company Snapshot
Table 106: Cytori Therapeutics Inc.: Company Snapshot
Table 107: Mattek: Company Snapshot
Table 108: Mimetas Inc.: Company Snapshot
Table 109: Organovo Holdings Inc.: Company Snapshot
Table 110: PerkinElmer Inc.: Company Snapshot
Table 111: Plasticell Ltd.: Company Snapshot
Table 112: Pluristem Therapeutics Inc.: Company Snapshot
Table 113: Poietis: Company Snapshot
Table 114: Promega Corp.: Company Snapshot
Table 115: SeaHorse Bioscience: Company Snapshot
Table 116: Stemcell Technologies: Company Snapshot
Table 117: Stratatech Corp.: Company Snapshot
Table 118: Synvivo Inc.: Company Snapshot
Table 119: Tap Biosystems: Company Snapshot
Table 120: Tecan Trading AG: Company Snapshot
Table 121: Zen-Bio Inc.: Company Snapshot
List of Figures
Summary Figure: Global Market for 3D Cell Culture, by Segment, 2020-2028
Figure 1: Research Chain for Cell Culture
Figure 2: A Model for The Evolution of FDA Regulation
Figure 3: 3D Cell Cultures: Market Dynamics
Figure 4: An Innovation Matrix
Figure 5: Bioprinting Strategic Roadmap
Figure 6: Global Market Shares of 3D Cell Culture, by Segment, 2022
Figure 7: Gastrointestinal Organotype Cultures
Figure 8: iCELLis Nanoreactor: Example of Commercial 2D Cell Culture Systems
Figure 9: Prototype of 3D Model Lung-on-a-Chip from Wake Forest
Figure 10: Recent Photo of the HepaChip
Figure 11: Recent Photo of the HepaChip-MWP
Figure 12: University of Toronto Handheld Bioprinting Device
Figure 13: Collaborative Experiment Conducted by American, Russian and Israeli Scientists
Figure 14: Smart Marbles Concept for Quantifying Process Heterogeneity
Figure 15: Porcine Intestinal Organoids
Figure 16: Diagram of the Components of a Predictive Toxicology System
Figure 17: Gleason’s Pattern
Figure 18: Diagram of PDXs, Cell Lines and Organoid/Spheroid Xenografts
Figure 19: Cell Heterogeneity and Its Function
Figure 20: Global Market for Cell Culture by Region, 2020-2028
Figure 21: North American Market for Cell Culture by Country, 2020-2028
Figure 22: European Market for Cell Culture by Country, 2020-2028
Figure 23: Asia-Pacific Market for Cell Culture by Country, 2020-2028
Figure 24: ROW Market for Cell Culture by Region, 2020-2028
Figure 25: Electron Micrograph of Porous Microcarrier for Stem Cell Production
Figure 26: Photograph of Apligraf
Figure 27: Abcam PLC: Financial Performance, 2021 and 2022
Figure 28: Abcam PLC: Revenue Shares, by Country/Region, 2022
Figure 29: Agilent Technologies Inc.: Financial Performance, 2021 and 2022
Figure 30: Agilent Technologies Inc.: Revenue Shares, by Business Unit, 2022
Figure 31: Agilent Technologies Inc.: Revenue Shares, by Country/Region, 2022
Figure 32: Corning Inc.: Revenue Shares, by Business Unit, FY 2022
Figure 33: Corning Inc.: Revenue Shares, by Region, FY 2022
Figure 34: Merck KGAA: Revenue Shares, by Business Unit, FY 2022
Figure 35: Merck KGAA: Revenue Shares, by Region, FY 2022

Executive Summary

This chapter also offers both fundamental information and important matters in the market. These include an introduction to basic distinctions such as the differences between in vitro and in vivo and changes in the marketplace. It also deals with matters that need closer scrutiny, such as the growing calls for standardization and how innovation is taking on new and unexpected features affecting future commercialization initiatives.

3D cell culture technologies are a powerful tool for studying cell biology, disease mechanisms and drug discovery. 3D cell culture models mimic the 3D structure and cell-cell interactions that are found in real tissues, making them more accurate and predictive than traditional 2D cell culture models.

There are a variety of 3D cell culture technologies available, including -

  • Scaffold-based 3D cell culture: This approach uses a scaffold to provide a 3D support structure for cells to grow on. Scaffolds can be made from a variety of materials, including natural polymers, synthetic polymers and hydrogels.
  • Scaffold-free 3D cell culture: This approach does not use a scaffold. Instead, cells are grown in a suspension of culture medium and gel-forming agents, such as collagen or Matrigel.
  • Bioprinting: This approach uses a 3D printer to deposit cells and biomaterials layer-by-layer to create complex 3D cell culture models.

3D cell culture technologies have a wide range of applications, including -

  • Drug discovery: 3D cell culture models can be used to screen new drug candidates for safety and efficacy before they are tested in clinical trials. 3D cell culture models can also be used to study the mechanisms of drug resistance and to develop new strategies to overcome drug resistance.
  • Disease modeling: 3D cell culture models can be used to study the biology of diseases and to develop new treatments. For example, 3D cancer models can be used to study tumor growth and metastasis, and 3D neurodegenerative disease models can be used to study the progression of neurodegenerative diseases.
  • Regenerative medicine: 3D cell culture models can be used to develop new cell-based therapies for a variety of diseases. For example, 3D skin models can be used to grow new skin for patients with burns or other skin injuries, and 3D liver models can be used to grow new liver tissue for patients with liver disease.

Companies Mentioned

  • 3D Bioprinting Solutions
  • 3D Biotek Llc
  • 4D Technology Corp.
  • Abcam Plc
  • Akron Biotech
  • Agilent Technologies Inc.
  • Alpco
  • Amsbio
  • Beckman Coulter Inc.
  • Bioinspired Solutions
  • Biotime Inc.
  • Biovision Inc.
  • Cell Applications Inc.
  • Cellink
  • Corning Inc.
  • Cyprotex
  • Cytiva
  • Cytoo Sa
  • Emd Millipore / Merck Kgaa
  • Emulate Inc.
  • Envisiontec Inc.
  • Epithelix
  • Eurofins Sas
  • Greiner Bio-One International Gmbh
  • Hamilton Robotics
  • Hub Organoids
  • Hurel Corp.
  • Insphero
  • Invitrocue
  • Kiyatec Inc.
  • Lifenet Health
  • Lorem Vascular / Cytori Therapeutics Inc.
  • Mattek
  • Mimetas Inc.
  • Organovo Holdings Inc.
  • Perkinelmer Inc.
  • Plasticell Ltd.
  • Pluristem Therapeutics Inc.
  • Poietis
  • Promega Corp.
  • Seahorse Bioscience
  • Stemcell Technologies
  • Stratatech Corp.
  • Synvivo Inc.
  • Tap Biosystems
  • Tecan Trading Ag
  • Zen-Bio Inc.

Table Information