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Non-muscle Invasive Bladder Cancer (NMIBC) - Epidemiology Forecast - 2034

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    Report

  • 107 Pages
  • January 2024
  • Region: Global
  • DelveInsight
  • ID: 5144517

Key Highlights

  • In 2023, in the 7MM there were around 1,500,000 diagnosed prevalent cases of NMIBC.
  • In 2023, the highest cases of NMIBC were at stage Ta, followed by T1, while the least prevalent cases were at stage Tis with 12,000 cases in the United States.
  • NMIBC is an age-associated malignancy, with a median age at diagnosis of 73 years and individuals aged 70-90 years accounting for the largest percentage
  • In Japan, stage-specific cases of NMIBC were highest in the Ta stage, accounting for approximately 60% in 2023.
This “Non-muscle Invasive Bladder Cancer - Epidemiology Forecast - 2034” report delivers an in-depth understanding of Non-muscle Invasive Bladder Cancer, historical and forecasted epidemiology trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

Geography Covered

  • The United States
  • EU4 (Germany, France, Italy, and Spain) and the United Kingdom
  • Japan
Study Period: 2020-2034

Non-muscle Invasive Bladder Cancer Disease Understanding

Non-muscle Invasive Bladder Cancer Overview

Non-muscle-invasive bladder cancer represents a category of bladder cancer where the tumor is confined to the innermost layer of the bladder lining without invading the muscle. This early-stage form accounts for a significant proportion of bladder cancer cases. NMIBC is often characterized by superficial tumor growth and typically presents with papillary tumors or carcinoma in situ. Due to its propensity for recurrence and progression, NMIBC requires vigilant management, involving transurethral resection of the tumor (TURBT) and subsequent intravesical therapies like Bacillus Calmette-Guérin (BCG) immunotherapy or chemotherapy. Surveillance through regular cystoscopies and adherence to guidelines are essential to monitor and manage this condition effectively.

Non-muscle Invasive Bladder Cancer Diagnosis

The diagnosis of NMIBC relies upon cystoscopy and tissue sampling. Initial cystoscopic evaluation is often performed in the office setting with or without biopsies of visualized tumors(s). Flexible cystoscopy in conjunction with topical intraurethral anesthetic lubricant decreases patient discomfort during the procedure, particularly in men. Most cases of NMIBC are initially treated with transurethral resection, but careful cystoscopic examination of the entire urethra and bladder should precede resection. However, surgeons may proceed directly to TURBT should CT or MRI reveal a bladder lesion during the evaluation of hematuria. During resection, tumors of significant size should be resected and labeled. The anatomic location of tumors with respect to the bladder neck and ureteral orifices, tumor configuration (papillary or sessile), as well as both the size and number of tumors should be documented in some consistent manner (e.g., diagram, text description) to inform future follow-up and evaluate treatment response.

Further details related to diagnosis are provided in the report.

Non-muscle Invasive Bladder Cancer Epidemiology

The Non-muscle invasive bladder cancer (NMIBC) epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by the total prevalent cases of NMIBC, stage-specific cases of NMIBC, grade-specific cases of NMIBC, risk-specific cases of NMIBC, and age-specific cases of NMIBC in the 7MM covering the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2020 to 2034.
  • Among the 7MM, the US accounted for the highest number of cases in 2023, with around 600,000 prevalent cases, these cases are expected to increase during the forecast period.
  • Among EU4 and the UK, the total prevalent cases of NMIBC was maximum in Italy, while the lowest number of cases were in France, in 2023.
  • Among cases categorized by risk level, the highest number belonged to the intermediate-risk category, whereas the lowest number was associated with the high-risk category.
  • According to the estimates, in Japan, it is observed that NMIBC was most prevalent in the 70-89 age group, accounting for approximately 60% of total cases in 2023.

Scope of the Report

  • The report covers a segment of key events, an executive summary, descriptive overview of short bowel syndrome, explaining its causes, signs and symptoms, pathogenesis, and diagnostic approaches.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of diagnosis rate, and disease progression.
  • A detailed review of the short bowel syndrome epidemiology, detailed assumptions, and rationale behind our approach is included in the report.
  • A detailed review of current challenges in establishing the diagnosis.

Non-muscle Invasive Bladder Cancer Report Insights

  • Patient Population
  • Country-wise Epidemiology Distribution
  • Age-specific Cases of Non-muscle Invasive Bladder Cancer
  • Stage-specific Cases of Non-muscle Invasive Bladder Cancer

Non-muscle Invasive Bladder Cancer Report Key Strengths

  • Eleven Years Forecast
  • The 7MM Coverage
  • Non-muscle Invasive Bladder Cancer Epidemiology Segmentation

Non-muscle Invasive Bladder Cancer Report Assessment

  • Epidemiology Segmentation
  • Current Diagnostic Practices

Epidemiology Insights

  • What are the disease risks, burdens, and unmet needs of Non-muscle Invasive Bladder Cancer? What will be the growth opportunities across the 7MM concerning the patient population with Non-muscle Invasive Bladder Cancer?
  • What is the historical and forecasted Non-muscle Invasive Bladder Cancer patient pool in the United States, EU4 (Germany, France, Italy, and Spain) the United Kingdom, and Japan?
  • Which stage-specific cases of Non-muscle Invasive Bladder Cancer is the largest contributor?
  • What is the diagnosis rate of Non-muscle Invasive Bladder Cancer?

Reasons to Buy

  • Insights on patient burden/disease, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • To understand the age-specific Non-muscle Invasive Bladder Cancer prevalent cases in varying geographies over the coming years.
  • A detailed overview of grade-specific and gender-specific cases of Non-muscle Invasive Bladder Cancer is an inclusion.
  • To understand the perspective of key opinion leaders around the current challenges with establishing the diagnosis and insights on the recurrent and treatment-eligible patient pool.
  • Detailed insights on various factors hampering disease diagnosis and other existing diagnostic challenges.

Table of Contents

1. Key Insights2. Report Introduction3. Executive Summary of NMIBC
4. NMIBC Epidemiology Overview at a Glance
4.1. Patient Share (%) of NMIBC in 2020 in the 7MM
4.2. Patient Share (%) of NMIBC in 2034 in the 7MM
5. Epidemiology Methodology
6. Disease Background and Overview: Non-muscle Invasive Bladder Cancer (NMIBC)
6.1. Introduction
6.2. Sign and Symptoms
6.3. Clinical Stages of NMIBC
6.4. Grading
6.5. The Risk Stratification of NMIBC
6.6. Diagnosis of NMIBC
6.6.1. Cystoscopy
6.6.2. Urinary Cytology - Urinary Molecular Marker Tests
6.6.3. Rigid Cystoscopy
6.6.3.1. Transurethral resection of bladder tumors (TURBT)
6.6.3.2. Blue light cystoscopy
6.7. American Urological Association Guidelines for NMIBC: 2020
6.8. European Association of Urology (EAU) Guidelines for Diagnosis of NMIBC
6.8.1. Signs and symptoms
6.8.2. Imaging
6.8.2.1. Computed Tomography Urography and Intravenous Urography
6.8.2.2. Ultrasound
6.8.2.3. Multi-parametric Magnetic Resonance Imaging
6.8.3. Urinary Cytology
6.8.4. Urinary Molecular Marker Tests
6.8.5. Potential Application of Urinary Cytology and Markers
6.8.5.1. Screening of the population at risk of bladder cancer
6.8.5.2. Exploration of patients after hematuria or other symptoms suggestive of bladder cancer (primary detection)
6.8.5.3. Surveillance of non-muscle-invasive bladder cancer
6.8.6. Cystoscopy
6.8.7. Transurethral Resection of TaT1 Bladder Tumors
6.8.7.1. The Strategy of the Procedure
6.8.7.2. Surgical and Technical Aspects of Tumor Resection
6.8.7.3. Endoscopic biopsies
6.8.8. New Methods of Tumor Visualization
6.8.8.1. Photodynamic diagnosis (fluorescence cystoscopy)
6.8.8.2. Narrow-band imaging
6.8.9. Second Resection
6.8.10. Pathology Report
6.8.11. EAU Evidence and Recommendations for Transurethral Resection of the Bladder, Biopsies and Pathology Report
7. Epidemiology and Patient Population
7.1. Key Findings
7.2. Assumptions and Rationale
7.3. Total Prevalent Cases of Bladder Cancer in the 7MM
7.4. Total Prevalent Cases of NMIBC in the 7MM
7.5. The United States
7.5.1. Total Prevalent Cases of NMIBC in the United States
7.5.2. Stage-specific Cases of NMIBC in the United States
7.5.3. Grade-specific Cases of NMIBC in the United States
7.5.4. Risk-specific Cases of NMIBC in the United States
7.5.5. Age-specific Cases of NMIBC in the United States
7.6. EU4 and the UK
7.6.1. Total Prevalent Cases of NMIBC in EU4 and the UK
7.6.2. Stage-specific Cases of NMIBC in EU4 and the UK
7.6.3. Grade-specific Cases of NMIBC in EU4 and the UK
7.6.4. Risk-specific Cases of NMIBC in EU4 and the UK
7.6.5. Age-specific Cases of NMIBC in EU4 and the UK
7.7. Japan
7.7.1. Total Prevalent Cases of NMIBC in Japan
7.7.2. Stage-specific Cases of NMIBC in Japan
7.7.3. Grade-specific Cases of NMIBC in Japan
7.7.4. Risk-specific Cases of NMIBC in Japan
7.7.5. Age-specific Cases of NMIBC in Japan
8. Patient Journey
9. Appendix
9.1. Abbreviations
9.2. Bibliography
9.3. Report Methodology
10. Publisher Capabilities11. Disclaimer12. About the Publisher
List of Tables
Table 1: Summary of NMIBC Epidemiology (2020-2034)
Table 2: WHO grading in 1973 and in 2004
Table 3: Risk stratification of NMIBC according to EAU and NICE guidelines
Table 4: Summary of Evidence And Guidelines for Transurethral Resection of the Bladder, Biopsies, And Pathology Report
Table 5: Recommendations for Transurethral Resection of The Bladder, Biopsies, And Pathology Report
Table 6: Total Prevalent Cases of Bladder Cancer in the 7MM in Thousand (2020-2034)
Table 7: Total Prevalent Cases of NMIBC in the 7MM in Thousand (2020-2034)
Table 8: Total Prevalent Cases of NMIBC in the United States (2020-2034)
Table 9: Stage-specific Cases of NMIBC in the United States (2020-2034)
Table 10: Grade-specific Cases of NMIBC in the United States (2020-2034)
Table 11: Risk-specific Cases of NMIBC in the United States (2020-2034)
Table 12: Age-specific Cases of NMIBC in the United States (2020-2034)
Table 13: Total Prevalent Cases of NMIBC in EU4 and the UK (2020-2034)
Table 14: Stage-specific Cases of NMIBC in EU4 and the UK (2020-2034)
Table 15: Grade-specific Cases of NMIBC in EU4 and the UK (2020-2034)
Table 16: Risk-specific Cases of NMIBC in EU4 and the UK (2020-2034)
Table 17: Age-specific Cases of NMIBC in EU4 and the UK (2020-2034)
Table 18: Total Prevalent Cases of NMIBC in Japan (2020-2034)
Table 19: Stage-specific Cases of NMIBC in Japan (2020-2034)
Table 20: Grade-specific Cases of NMIBC in Japan (2020-2034)
Table 21: Risk-specific Cases of NMIBC in Japan (2020-2034)
Table 22: Age-specific Cases of NMIBC in Japan (2020-2034)
List of Figures
Figure 1: Different Stages of NMIBC
Figure 2: Risk Stratification of NMIBC
Figure 3: Management per NMIBC risk group
Figure 4: Total Prevalent Cases of Bladder Cancer in the 7MM (2020-2034)
Figure 5: Total Prevalent Cases of NMIBC in the 7MM (2020-2034)
Figure 6: Total Prevalent Cases of NMIBC in the United States (2020-2034)
Figure 7: Stage-specific Cases of NMIBC in the United States (2020-2034)
Figure 8: Grade-specific Cases of NMIBC in the United States (2020-2034)
Figure 9: Risk-specific Cases of NMIBC in the United States (2020-2034)
Figure 10: Age-specific Cases of NMIBC in the United States (2020-2034)
Figure 11: Total Prevalent Cases of NMIBC in EU4 and the UK (2020-2034)
Figure 12: Stage-specific Cases of NMIBC in EU4 and the UK (2020-2034)
Figure 13: Grade-specific cases of NMIBC in EU4 and the UK (2020-2034)
Figure 14: Risk-specific cases of NMIBC in EU4 and the UK (2020-2034)
Figure 15: Age-specific cases of NMIBC in EU4 and the UK (2020-2034)
Figure 16: Total Prevalent Cases of NMIBC in Japan (2020-2034)
Figure 17: Stage-specific Cases of NMIBC in Japan (2020-2034)
Figure 18: Grade-specific Cases of NMIBC in Japan (2020-2034)
Figure 19: Risk-specific cases of NMIBC in Japan (2020-2034)
Figure 20: Age-specific cases of NMIBC in Japan (2020-2034)