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Total Chemical Synthesis of Proteins. Edition No. 1

  • ID: 5185547
  • Book
  • March 2021
  • 600 Pages
  • John Wiley and Sons Ltd
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How to synthesize any native or modified protein in the test tube 

With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins in the test tube.   

Comprehensive in scope, this important reference explores the three main ligation methods: native chemical ligation, sugar-assisted ligation, and ketoacid-hydroxylamine ligation. It includes information on synthetic strategies for various protein types, including glycoproteins, sulfoproteins, and membrane proteins. The most important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research.  The authors also provide insight on the challenges that remain to be unravelled. This unmatched resource: 

  • Contains valuable insights from the pioneers in the field of native chemical ligation 
  • Presents proven synthetic approaches for a wide range of different protein types 
  • Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics 

Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.   

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Characterization of synthetic proteins
Native chemical ligation
N to S acyl shifts in protein synthesis
Hydrazide-based protein synthesis
Chemical ubiquitination
Glycoprotein synthesis
Expediting protein synthesis
Synthesis of membrane proteins
Sugar-assisted ligation in protein synthesis
Protein semisynthesis
Expanding native chemical ligation via novel amino acid derivatives
Oxime ligation
Synthesis of selenoproteins
Purification-free ligations
Controlling segment solubility in large protein synthesis
Total chemical synthesis of proteins in neurodegenerative diseases
Solid phase chemical ligation
Auxiliaries in chemical protein synthesis
Peptide ligations at sterically demanding sites
Protein synthesis applied for backbone protein engineering
Histone synthesis
Cylic peptide and protein synthesis via ligation methods
Synthesis of proteins with post-translational modification mimics
Deciphering protein folding using chemical protein synthesis
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Lei Liu
Ashraf Brik
Philip Dawson
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