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Successful Drug Discovery, Volume 5. Edition No. 1

  • ID: 5185672
  • Book
  • March 2021
  • 320 Pages
  • John Wiley and Sons Ltd
Filled with unique insights into current drugs that have made it to the marketplace

In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drugÂs discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the bookÂs nine chapters provide a representative cross-section of the present-day drug development effort.

The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume:
- Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references
- Contains information and insight that is new and often not even available from the primary literature
- Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market
- Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC)

Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process.
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GENERAL ASPECTS
Drug Discovery in Academia
Intracellular Degraders and Other Small Molecules Targeting Protein-Protein Interactions

DRUG CLASS STUDIES
CGRP Blockers for Migraine Treatment
GLP-1 Agonists
Oligonucleotide Therapeutics
CART-T Therapy
SGLT2 Inhibitors

CASE STUDIES
Emicizumab
Ivosidenib
Ribociclib
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Janos Fischer
Christian Klein
Wayne E. Childers
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