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Melanocortin Receptor 4 - Pipeline Review, H2 2020

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    Drug Pipelines

  • 83 Pages
  • October 2020
  • Region: Global
  • Global Markets Direct
  • ID: 5189168
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Summary

Melanocortin Receptor 4 (MC4R) pipeline Target constitutes close to 12 molecules. Out of which approximately 10 molecules are developed by companies and remaining by the universities/institutes. The latest report Melanocortin Receptor 4 - Pipeline Review, H2 2020, outlays comprehensive information on the Melanocortin Receptor 4 (MC4R) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Melanocortin Receptor 4 (MC4R) - Melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in the hypothalamic leptin-melanocortin signaling pathway. MC4R is encoded by the MC4R gene. Activation of the MC4R plays a key role in the maintenance of energy homeostasis and is associated with suppression of food intake. The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I and Preclinical stages are 1, 1, 1, 2 and 5 respectively. Similarly, the universities portfolio in Discovery stages comprises 2 molecules, respectively. Report covers products from therapy areas Metabolic Disorders, Genetic Disorders, Musculoskeletal Disorders, Central Nervous System, Genito Urinary System And Sex Hormones and Immunology which include indications Obesity, Type 2 Diabetes, Cachexia, Gouty Arthritis (Gout), IgA Nephropathy (Berger's Disease), Infantile Spasm (West Syndrome), Lipodystrophy (Lipoatrophy), Metabolic Syndrome, Multiple Sclerosis, Prader-Willi Syndrome (PWS), Rheumatoid Arthritis and Smith-Magenis Syndrome (Chromosome 17p11.2 Deletion Syndrome).

Furthermore, this report also reviews key players involved in Melanocortin Receptor 4 (MC4R) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope
  • The report provides a snapshot of the global therapeutic landscape for Melanocortin Receptor 4 (MC4R)
  • The report reviews Melanocortin Receptor 4 (MC4R) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Melanocortin Receptor 4 (MC4R) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Melanocortin Receptor 4 (MC4R) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Melanocortin Receptor 4 (MC4R) targeted therapeutics

Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Melanocortin Receptor 4 (MC4R)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Melanocortin Receptor 4 (MC4R) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

Introduction
  • Report Coverage

Melanocortin Receptor 4 (MC4R) - Overview
Melanocortin Receptor 4 (MC4R) - Therapeutics Development
  • Products under Development by Stage of Development
  • Products under Development by Therapy Area
  • Products under Development by Indication
  • Products under Development by Companies
  • Products under Development by Universities/Institutes

Melanocortin Receptor 4 (MC4R) - Therapeutics Assessment
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type

Melanocortin Receptor 4 (MC4R) - Companies Involved in Therapeutics Development
  • Aequus BioPharma Inc
  • Eton Pharmaceuticals Inc
  • LG Chem Ltd
  • Mallinckrodt Plc
  • Palatin Technologies Inc
  • Rhythm Pharmaceuticals Inc

Melanocortin Receptor 4 (MC4R) - Drug Profiles
(liraglutide + setmelanotide hydrochloride) - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

AQB-565 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

bremelanotide acetate - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

corticotropin - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

corticotropin - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

LB-54640 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

LR-19021 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

PL-8905 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

PL-9610 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

setmelanotide hydrochloride - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

setmelanotide hydrochloride ER - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Small Molecules to Agonize MC4-R for Obesity - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Small Molecules to Antagonize Melanocortin-4 Receptor for Cachexia - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Melanocortin Receptor 4 (MC4R) - Dormant ProductsMelanocortin Receptor 4 (MC4R) - Discontinued Products
Melanocortin Receptor 4 (MC4R) - Product Development Milestones
  • Featured News & Press Releases
  • Oct 20, 2020: City of Rockford $10 billion lawsuit against pharmaceutical giant Mallinckrodt threatened by bankruptcy
  • Sep 28, 2020: LG Chem's obesity treatment wins ODD status in US
  • Jul 16, 2020: Rhythm Pharmaceuticals announces publication of results from phase 2 study of Setmelanotide in Bardet-Biedl Syndrome in diabetes, obesity and metabolism
  • Jul 06, 2020: MC4R agonist (LB54640) Poster Presentation at ADA 2020
  • Jul 01, 2020: Rhythm Pharmaceuticals announces submission of Marketing Authorization Application to the European Medicines Agency for setmelanotide in POMC and LEPR deficiency obesities
  • Jul 01, 2020: Rhythm Pharmaceuticals receives rare pediatric disease designation from U.S. Food and Drug Administration for setmelanotide for treatment of POMC and LEPR deficiency obesities
  • Jun 24, 2020: Positive results from Phase 2 study of once-weekly FluidCrystal formulation of setmelanotide in healthy volunteers with obesity
  • Jun 24, 2020: Rhythm Pharmaceuticals announces positive results from phase 2 study of once-weekly formulation of setmelanotide in healthy obese volunteers
  • Jun 15, 2020: Mallinckrodt to proceed with appeal despite appellate court decision denying temporary injunction in ongoing Acthar Gel medicaid drug rebate dispute with the Centers for Medicare and Medicaid Services (CMS)
  • Jun 15, 2020: Mallinckrodt to proceed with appeal despite appellate court decision denying temporary injunction in ongoing Acthar Gel medicaid drug rebate dispute with the Centers for Medicare and Medicaid Services (CMS)
  • Jun 01, 2020: Mallinckrodt will appeal District Court ruling in case involving ongoing Acthar medicaid drug rebate dispute with the Centers for Medicare and Medicaid Services (CMS)
  • Jun 01, 2020: LG Chem Life Sciences Company receives FDA approval for IND application of LB54640 for the treatment of genetic disorders of obesity
  • May 13, 2020: Rhythm Pharmaceuticals announces FDA acceptance of new drug application for Setmelanotide for the treatment of POMC and LEPR deficiency obesities
  • Apr 15, 2020: Mallinckrodt announces publication of data on Acthar Gel (Repository Corticotropin Injection) from its randomized, double-blind, placebo-controlled phase 4 study in rheumatoid arthritis (RA) in Rheumatology and Therapy
  • Mar 30, 2020: Rhythm Pharmaceuticals completes rolling submission of New Drug Application to U.S. Food and Drug Administration for Setmelanotide in POMC and LEPR deficiency obesities

Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact
  • Disclaimer

List of Tables
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Indication, H2 2020
  • Number of Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020 (Contd..1), H2 2020
  • Number of Products under Investigation by Universities/Institutes, H2 2020
  • Products under Investigation by Universities/Institutes, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Stage and Route of Administration, H2 2020
  • Number of Products by Stage and Molecule Type, H2 2020
  • Pipeline by Aequus BioPharma Inc, H2 2020
  • Pipeline by Eton Pharmaceuticals Inc, H2 2020
  • Pipeline by LG Chem Ltd, H2 2020
  • Pipeline by Mallinckrodt Plc, H2 2020
  • Pipeline by Palatin Technologies Inc, H2 2020
  • Pipeline by Rhythm Pharmaceuticals Inc, H2 2020
  • Dormant Products, H2 2020
  • Dormant Products, H2 2020 (Contd..1), H2 2020
  • Discontinued Products, H2 2020

List of Figures
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Top 10 Indications, H2 2020
  • Number of Products by Mechanism of Actions, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Routes of Administration, H2 2020
  • Number of Products by Stage and Routes of Administration, H2 2020
  • Number of Products by Molecule Types, H2 2020
  • Number of Products by Stage and Molecule Types, H2 2020

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Aequus BioPharma Inc
  • Eton Pharmaceuticals Inc
  • LG Chem Ltd
  • Mallinckrodt Plc
  • Palatin Technologies Inc
  • Rhythm Pharmaceuticals Inc