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Global Refractory Status Epilepticus (RSE) - Patient & Segmentation, Historical and Forecast to 2029

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    Report

  • 98 Pages
  • December 2019
  • Region: Global
  • Quintana Research and Consulting
  • ID: 5206198
The report titled “Global Refractory Status Epilepticus (RSE) - Patient & Segmentation, Historical and Forecast to 2029” offers strategic insights into the global RSE patient population along with the Patient Segmentation and estimates for the duration 2018 to 2029.

Refractory status epilepticus is defined as persistent seizures despite appropriate use of two intravenous medications, one of which is a benzodiazepine. It can be seen in up to 40% of cases of status epilepticus with an acute symptomatic etiology as the most likely cause. New-onset refractory status epilepticus (NORSE) is a recently coined term for refractory status epilepticus where no apparent cause is found after initial testing

The seven major incidence of Refractory Status Epilepticus (RSE) is expected to grow at a CAGR of around 0.55% during 2018-2029. It has been observed that approximately 30-40% of status epilepticus patient are refractory to first and second line treatment (known as refractory status epilepticus) throughout the seven major market. The United States have the majority of the patient population

Historical & Forecast Period
  • Base Year: 2018
  • Historical Period: 2018-2019
  • Forecast Period: 2020-2029

Report’s Scope

The purpose of this strategic research study titled “Global Refractory Status Epilepticus (RSE) - Patient & Segmentation, Historical and Forecast to 2029” is to offer industry investors, company executives, and industry participants with in-depth insights to enable them make informed strategic decisions related to the opportunities in the global refractory status epilepticus (RSE) market. The said research study covers in-depth analysis of affected patient population and its segmentation by geography. The report covers the patient population by gender as well as by age along with all the assumptions considered in different geographies.

Patient Segmentation
  • Patient Population of Status Epilepticus (SE)
  • Patient Population of Status Epilepticus (SE) by Type
  • Patient Population of Status Epilepticus (SE) by Age
  • Number of Status Epilepticus (SE) Patients on First Line Treatment
  • Number of Established Status Epilepticus Patients on Second Line Treatment

Regional Segmentation
  • Europe
  • Germany
  • Italy
  • France
  • United Kingdom
  • Spain
  • North America
  • United States
  • Asia Pacific
  • Japan

Table of Contents

1.Table of Contents
1.1. List of Tables
1.2. List of Figures
2. Preface
2.1. Report Description
2.1.1. Objective of the Report
2.1.2. Target Audience
2.1.3. USP & Key Offerings
2.2. Report’s Scope
2.3. Research Methodology
2.3.1. Phase I- Secondary Research
2.3.2. Phase II- Primary Research
2.3.3. Expert Interviews
2.3.4. Assumptions
3. Executive Summary
3.1. Epidemiology Snapshot
3.1.1. Refractory Status Epilepticus (RSE) Patient Population in 2018
3.1.2. Refractory Status Epilepticus (RSE) Patient Population in 2029
4. Key Insights
4.1. Epidemiology of Refractory Status Epilepticus (RSE) in the Seven Major Markets, 2018
4.2. Market Definition & Methodology
5. Refractory Status Epilepticus (RSE)
5.1. Refractory Status Epilepticus (RSE) Definition
5.2. Changing Definition
5.3. Signs and Symptoms -NORSE
5.4. Cause
5.5. Types of Status Epilepticus
5.6. Diagnosis
5.6.1. Electroencephalography
5.6.2. Imaging
5.6.3. Neuroimaging
5.7. Pathophysiology
5.8. Management
5.8.1. Initial Management of Status Epilepticus
6. Current Unmet Need and Opportunities
7. Seven Major Markets Epidemiology and Segmentation
7.1. Key Findings/Summary
7.2. Refractory Status Epilepticus (RSE) Definition
7.3. Epidemiology Forecast Methodology
7.4. Assumptions & Sources Used
7.5. Incidence of Status Epilepticus (SE) in the Seven Major Market
7.6. Incidence of Refractory Status Epilepticus (RSE) in the Seven Major Markets
8. Epidemiology by Countries
8.1. North America
8.2. United States
8.2.1. Incidence of Status Epilepticus (SE) in the United States
8.2.2. Incidence of Status Epilepticus (SE) by Type in the United States
8.2.3. Incidence of Status Epilepticus (SE) by Age in the United States
8.2.4. Number of Status Epilepticus (SE) Patients on First Line Treatment in the United States
8.2.5. Number of Established Status Epilepticus Patients on Second Line Treatment in the United States
8.3. 5-Europe
8.3.1. United Kingdom
8.3.1.1. Incidence of Status Epilepticus (SE) in the United Kingdom
8.3.1.2. Incidence of Status Epilepticus (SE) by Type in the United Kingdom
8.3.1.3. Incidence of Status Epilepticus (SE) by Age in the United Kingdom
8.3.1.4. Number of Status Epilepticus (SE) Patients on First Line Treatment in the United Kingdom
8.3.1.5. Number of Established Status Epilepticus Patients on Second Line Treatment in the United Kingdom
8.3.2. Germany
8.3.2.1. Incidence of Status Epilepticus (SE) in Germany
8.3.2.2. Incidence of Status Epilepticus (SE) by Type in Germany
8.3.2.3. Incidence of Status Epilepticus (SE) by Age in Germany
8.3.2.4. Number of Status Epilepticus (SE) Patients on First Line Treatment in Germany
8.3.2.5. Number of Established Status Epilepticus Patients on Second Line Treatment in Germany
8.3.3. Italy
8.3.3.1. Incidence of Status Epilepticus (SE) in Italy
8.3.3.2. Incidence of Status Epilepticus (SE) by Type in Italy
8.3.3.3. Incidence of Status Epilepticus (SE) by Age in Italy
8.3.3.4. Number of Status Epilepticus (SE) Patients on First Line Treatment in Italy
8.3.3.5. Number of Established Status Epilepticus Patients on Second Line Treatment in Italy
8.3.4. France
8.3.4.1. Incidence of Status Epilepticus (SE) in France
8.3.4.2. Incidence of Status Epilepticus (SE) by Type in France
8.3.4.3. Incidence of Status Epilepticus (SE) by Age in France
8.3.4.4. Number of Status Epilepticus (SE) Patients on First Line Treatment in France
8.3.4.5. Number of Established Status Epilepticus Patients on Second Line Treatment in France
8.3.5. Spain
8.3.5.1. Incidence of Status Epilepticus (SE) in Spain
8.3.5.2. Incidence of Status Epilepticus (SE) by Type in Spain
8.3.5.3. Incidence of Status Epilepticus (SE) by Age in Spain
8.3.5.4. Number of Status Epilepticus (SE) Patients on First Line Treatment in Spain
8.3.5.5. Number of Established Status Epilepticus Patients on Second Line Treatment in Spain
8.4. Asia: Japan
8.4.1. Incidence of Status Epilepticus (SE) in Japan
8.4.2. Incidence of Status Epilepticus (SE) by Type in Japan
8.4.3. Incidence of Status Epilepticus (SE) by Age in Japan
8.4.4. Number of Status Epilepticus (SE) Patients on First Line Treatment in Japan
8.4.5. Number of Established Status Epilepticus Patients on Second Line Treatment in Japan
9. What do physicians think?
9.1. Key Opinion Leader Views
10. Conclusion
10.1. Patient Population in 2018 and 2029
10.2. Epidemiology Forecast 2019-2029
11. Disclaimer
List of Tables
Table 1 Diagnostic Investigations in Refractory status epilepticus; Basic workup for causes of RSE
Table 2 Second-line Antiepileptic Drugs
Table 3 Continuous Infusions for Refractory Status Epilepticus
Table 4 Prognosis
Table 5 Suggested Treatment Algorithm for Status Epilepticus Stages I and IIa
Table 6 Stage III Refractory Status Epilepticus
Table 7 Treatment recommendations for SE
Table 8 Proposed roadmap for future collaborative research investigating new-onset refractory status epilepticus (NORSE)
Table 9 Incidence of Status Epilepticus (SE) in the Seven Major Market (2018-2029)
Table 10 Number of Status Epilepticus (SE) Patients on First Line Treatment in the Seven Major Market (2018-2029)
Table 11 Incidence of Status Epilepticus (SE) in the United States (2018-2029)
Table 12 Incidence of Status Epilepticus (SE) by type in the United States (2018-2029)
Table 13 Incidence of Status Epilepticus (SE) by age in the United States (2018-2029)
Table 14 Number of Status Epilepticus (SE) Patients on First Line Treatment in the United States (2018-2029)
Table 15 Number of Established Status Epilepticus Patients on Second Line Treatment in the United States (2018-2029)
Table 16 Incidence of Status Epilepticus (SE) in the United Kingdom (2018-2029)
Table 17 Incidence of Status Epilepticus (SE) by type in the United Kingdom (2018-2029)
Table 18 Incidence of Status Epilepticus (SE) by age in the United Kingdom (2018-2029)
Table 19 Number of Status Epilepticus (SE) Patients on First Line Treatment in the United Kingdom (2018-2029)
Table 20 Number of Established Status Epilepticus Patients on Second Line Treatment in the United Kingdom (2018-2029)
Table 21 Incidence of Status Epilepticus (SE) in Germany (2018-2029)
Table 22 Incidence of Status Epilepticus (SE) by type in Germany (2018-2029)
Table 23 Incidence of Status Epilepticus (SE) by age in Germany (2018-2029)
Table 24 Number of Status Epilepticus (SE) Patients on First Line Treatment in Germany (2018-2029)
Table 25 Number of Established Status Epilepticus Patients on Second Line Treatment in Germany (2018-2029)
Table 26 Incidence of Status Epilepticus (SE) in Italy (2018-2029)
Table 27 Incidence of Status Epilepticus (SE) by type in Italy (2018-2029)
Table 28 Incidence of Status Epilepticus (SE) by age in Italy (2018-2029)
Table 29 Number of Status Epilepticus (SE) Patients on First Line Treatment in Italy (2018-2029)
Table 30 Number of Established Status Epilepticus Patients on Second Line Treatment in Italy (2018-2029)
Table 31 Incidence of Status Epilepticus (SE) in France (2018-2029)
Table 32 Incidence of Status Epilepticus (SE) by type in France (2018-2029)
Table 33 Incidence of Status Epilepticus (SE) by age in France (2018-2029)
Table 34 Number of Status Epilepticus (SE) Patients on First Line Treatment in France (2018-2029)
Table 35 Number of Established Status Epilepticus Patients on Second Line Treatment in France (2018-2029)
Table 36 Incidence of Status Epilepticus (SE) in Spain (2018-2029)
Table 37 Incidence of Status Epilepticus (SE) by type in Spain (2018-2029)
Table 38 Incidence of Status Epilepticus (SE) by age in Spain (2018-2029)
Table 39 Number of Status Epilepticus (SE) Patients on First Line Treatment in Spain (2018-2029)
Table 40 Number of Established Status Epilepticus Patients on Second Line Treatment in Spain (2018-2029)
Table 41 Incidence of Status Epilepticus (SE) in Japan (2018-2029)
Table 42 Incidence of Status Epilepticus (SE) by type in Japan (2018-2029)
Table 43 Incidence of Status Epilepticus (SE) by age in Japan (2018-2029)
Table 44 Number of Status Epilepticus (SE) Patients on First Line Treatment in Japan (2018-2029)
Table 45 Number of Established Status Epilepticus Patients on Second Line Treatment in Japan (2018-2029)
Table 46 Patient Population in 2018 and 2029
Table 47 Key Opinion Leader Views
List of Figures
Figure 1 Possible Triggers of Status Epilepticus
Figure 2 Acute Causes of Status Epilepticus
Figure 3 Receptor Changes in Prolonged status epilepticus
Figure 4 Current Unmet Need of RSE
Figure 5 Incidence of Status Epilepticus (SE) in the Seven Major Market (2018-2029)
Figure 6 Number of Status Epilepticus (SE) Patients on First Line Treatment in the Seven Major Market (2018-2029)
Figure 7 Incidence of Status Epilepticus (SE) in the United States (2018-2029)
Figure 8 Incidence of Status Epilepticus (SE) by type in the United States (2018-2029)
Figure 9 Incidence of Status Epilepticus (SE) by age in the United States (2018-2029)
Figure 10 Number of Status Epilepticus (SE) Patients on First Line Treatment in the United States (2018-2029)
Figure 11 Number of Established Status Epilepticus Patients on Second Line Treatment in the United States (2018-2029)
Figure 12 Incidence of Status Epilepticus (SE) in the United Kingdom (2018-2029)
Figure 13 Incidence of Status Epilepticus (SE) by type in the United Kingdom (2018-2029)
Figure 14 Incidence of Status Epilepticus (SE) by age in the United Kingdom (2018-2029)
Figure 15 Number of Status Epilepticus (SE) Patients on First Line Treatment in the United Kingdom (2018-2029)
Figure 16 Number of Established Status Epilepticus Patients on Second Line Treatment in the United Kingdom (2018-2029)
Figure 17 Incidence of Status Epilepticus (SE) in Germany (2018-2029)
Figure 18 Incidence of Status Epilepticus (SE) by type in Germany (2018-2029)
Figure 19 Incidence of Status Epilepticus (SE) by age in Germany (2018-2029)
Figure 20 Number of Status Epilepticus (SE) Patients on First Line Treatment in Germany (2018-2029)
Figure 21 Number of Established Status Epilepticus Patients on Second Line Treatment in Germany (2018-2029)
Figure 22 Incidence of Status Epilepticus (SE) in Italy (2018-2029)
Figure 23 Incidence of Status Epilepticus (SE) by type in Italy (2018-2029)
Figure 24 Incidence of Status Epilepticus (SE) by age in Italy (2018-2029)
Figure 25 Number of Status Epilepticus (SE) Patients on First Line Treatment in Italy (2018-2029)
Figure 26 Number of Established Status Epilepticus Patients on Second Line Treatment in Italy (2018-2029)
Figure 27 Incidence of Status Epilepticus (SE) in France (2018-2029)
Figure 28 Incidence of Status Epilepticus (SE) by type in France (2018-2029)
Figure 29 Incidence of Status Epilepticus (SE) by age in France (2018-2029)
Figure 30 Number of Status Epilepticus (SE) Patients on First Line Treatment in France (2018-2029)
Figure 31 Number of Established Status Epilepticus Patients on Second Line Treatment in France (2018-2029)
Figure 32 Incidence of Status Epilepticus (SE) in Spain (2018-2029)
Figure 33 Incidence of Status Epilepticus (SE) by type in Spain (2018-2029)
Figure 34 Incidence of Status Epilepticus (SE) by age in Spain (2018-2029)
Figure 35 Number of Status Epilepticus (SE) Patients on First Line Treatment in Spain (2018-2029)
Figure 36 Number of Established Status Epilepticus Patients on Second Line Treatment in Spain (2018-2029)
Figure 37 Incidence of Status Epilepticus (SE) in Japan (2018-2029)
Figure 38 Incidence of Status Epilepticus (SE) by type in Japan (2018-2029)
Figure 39 Incidence of Status Epilepticus (SE) by age in Japan (2018-2029)
Figure 40 Number of Status Epilepticus (SE) Patients on First Line Treatment in Japan (2018-2029)
Figure 41 Number of Established Status Epilepticus Patients on Second Line Treatment in Japan (2018-2029)
Figure 42 Patient Population in 2018 and 2029

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