A 3D cell culture is an in-vitro technique wherein the cells can grow in an artificially created environment. These environments closely resemble the architecture and functioning of the native tissue. 3D cell culture technique helps stimulate cell differentiation, proliferation, and migration by interacting with their three-dimensional surroundings as they would in the in-vivo environment. As 3D cell cultures can mimic the structure, activity, and microenvironment of the in-vivo tissues, this technique has varied applications in the fields of drug screening, regenerative medicine, stem cell therapies, cancer research and cell biology. The extracellular matrix in 3D cell cultures enables cell-cell communication by direct contact as in in-vivo environment by secreting cytokines and trophic factors. These factors are changed in a 2D environment that can significantly affect the cell-cell communication, which in turn can alter the cell morphology and proliferation. As 2D cultures cannot recapitulate the architecture and complex cellular matrices as in 3D cultures, this technique is gaining popularity in healthcare research sector. In addition, 3D cell cultures can provide results with improved efficiency and reduce the cost of overall R&D process.
Based on product, the 3D cell culture market can be categorized into scaffold-based platforms, scaffold-free platforms, gels, bioreactors, microchips, and services. Scaffold-based platforms are used to alter the cell culture procedure by providing a surface on which the cells can easily impart 3D growth. Scaffolds are used in drug discovery and cell expansion, owing to the availability of a variety of materials and structural choices. In addition, there are other advantages related to the use of scaffold-based platforms such as ease of imaging and simple assay protocol. Moreover, the mechanical and biochemical properties of the scaffold can easily be modified as per the need of the application. Thus, this segment is expected to dominate the product segment throughout the forecast period as there is a high demand for scaffold-based platforms for creating 3D cell cultures. Nevertheless, scaffold-based platforms can adsorb test compounds, limit downstream endpoints for analysis, and introduce different biological substances, thereby obstructing the segment growth.
Based on application, the 3D cell culture market is segmented into cancer research, stem cell research, drug discovery, and regenerative medicine. Cancer research segment is anticipated to be the largest growing segment over the analysis period. This is majorly attributed to the advantages offered by 3D cell culture in cancer research, these include ease of altering cell proliferation and morphology, revealing realistic drug response, capturing phenotypic heterogeneity, allowing experimental manipulation in gene expression & cell behavior and representing the tumor microenvironment. Preclinical studies that utilize the benefits of 3D cell culture early on can critically improvise the understanding of cancer biology. These include elimination of poor drug candidates and identification of physiologically relevant targets that were previously inaccessible in 2D cultures. This can largely contribute toward the segment growth.
Based on end user, the global 3D cell culture market is segmented into biotechnology & pharmaceutical companies, contract research laboratories, and academic institutes. The academic institutes segment held a dominant position in the end user segment throughout the analysis period. This growth is due to rise in collaborations between several companies with research institutes and clinical laboratories owing to the rise in demand of 3D cell cultures for various healthcare applications. For instance, Procter & Gamble (P&G) and Durham University based in the UK have collaborated for engineering 3D skin substitutes with the help of tissue-mimetic 2D platforms for studying the process of ageing in-vitro. In addition, many academic institutes have focused their R&D activities toward 3D culture models for developing novel approaches for treating different medical conditions. This surge in research activities across academic institutes and universities is predicted to propel the growth of the segment over the analysis period.
North America is expected to maintain its dominance during the forecast period due to the presence of several pharmaceutical and biotechnology companies that use 3D culture technology in collaboration with research institutes and clinical laboratories for developing regenerative medicines and drug discovery & development. Furthermore, rise in demand for organ transplantation and upsurge in R&D activities focused on technologically advanced solutions is predicted to fuel the adoption of 3D cell culture practices in the region. In addition, surge in incidences of cancer has led the government to increase the funding and grants for R&D in the field of cancer, which may have a positive impact on the 3D cell culture market growth. Moreover, the strategic expansion of biotechnological and pharmaceutical companies has led to launch of advanced products, which are expected to augment the market growth in coming years.
The market research is offered along with information related to key drivers, restraints, and opportunities.
Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
In-depth analysis of the 3d cell culture market segmentation assists to determine the prevailing market opportunities.
Major countries in each region are mapped according to their revenue contribution to the global market.
Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
The report includes the analysis of the regional as well as global 3d cell culture market trends, key players, market segments, application areas, and market growth strategies.
Based on product, the 3D cell culture market can be categorized into scaffold-based platforms, scaffold-free platforms, gels, bioreactors, microchips, and services. Scaffold-based platforms are used to alter the cell culture procedure by providing a surface on which the cells can easily impart 3D growth. Scaffolds are used in drug discovery and cell expansion, owing to the availability of a variety of materials and structural choices. In addition, there are other advantages related to the use of scaffold-based platforms such as ease of imaging and simple assay protocol. Moreover, the mechanical and biochemical properties of the scaffold can easily be modified as per the need of the application. Thus, this segment is expected to dominate the product segment throughout the forecast period as there is a high demand for scaffold-based platforms for creating 3D cell cultures. Nevertheless, scaffold-based platforms can adsorb test compounds, limit downstream endpoints for analysis, and introduce different biological substances, thereby obstructing the segment growth.
Based on application, the 3D cell culture market is segmented into cancer research, stem cell research, drug discovery, and regenerative medicine. Cancer research segment is anticipated to be the largest growing segment over the analysis period. This is majorly attributed to the advantages offered by 3D cell culture in cancer research, these include ease of altering cell proliferation and morphology, revealing realistic drug response, capturing phenotypic heterogeneity, allowing experimental manipulation in gene expression & cell behavior and representing the tumor microenvironment. Preclinical studies that utilize the benefits of 3D cell culture early on can critically improvise the understanding of cancer biology. These include elimination of poor drug candidates and identification of physiologically relevant targets that were previously inaccessible in 2D cultures. This can largely contribute toward the segment growth.
Based on end user, the global 3D cell culture market is segmented into biotechnology & pharmaceutical companies, contract research laboratories, and academic institutes. The academic institutes segment held a dominant position in the end user segment throughout the analysis period. This growth is due to rise in collaborations between several companies with research institutes and clinical laboratories owing to the rise in demand of 3D cell cultures for various healthcare applications. For instance, Procter & Gamble (P&G) and Durham University based in the UK have collaborated for engineering 3D skin substitutes with the help of tissue-mimetic 2D platforms for studying the process of ageing in-vitro. In addition, many academic institutes have focused their R&D activities toward 3D culture models for developing novel approaches for treating different medical conditions. This surge in research activities across academic institutes and universities is predicted to propel the growth of the segment over the analysis period.
North America is expected to maintain its dominance during the forecast period due to the presence of several pharmaceutical and biotechnology companies that use 3D culture technology in collaboration with research institutes and clinical laboratories for developing regenerative medicines and drug discovery & development. Furthermore, rise in demand for organ transplantation and upsurge in R&D activities focused on technologically advanced solutions is predicted to fuel the adoption of 3D cell culture practices in the region. In addition, surge in incidences of cancer has led the government to increase the funding and grants for R&D in the field of cancer, which may have a positive impact on the 3D cell culture market growth. Moreover, the strategic expansion of biotechnological and pharmaceutical companies has led to launch of advanced products, which are expected to augment the market growth in coming years.
Key Benefits For Stakeholders
This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the 3d cell culture market analysis from 2021 to 2031 to identify the prevailing 3d cell culture market opportunities.The market research is offered along with information related to key drivers, restraints, and opportunities.
Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
In-depth analysis of the 3d cell culture market segmentation assists to determine the prevailing market opportunities.
Major countries in each region are mapped according to their revenue contribution to the global market.
Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
The report includes the analysis of the regional as well as global 3d cell culture market trends, key players, market segments, application areas, and market growth strategies.
Key Market Segments
By Product
- Scaffold Free Platforms
- Gels
- Bioreactors
- Microchips
- Services
- Scaffold Based Platforms
- Macro-scale
- Micro-scale
- Nano-scale
- Solid Scaffolds
By Application
- Cancer Research
- Stem Cell Research
- Drug Discovery
- Regenerative medicine
By End User
- Biotechnology and Pharmaceutical Companies
- Contract Research Laboratories
- Academic Institutes
By Region
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- France
- UK
- Rest of Europe
- Asia-Pacific
- Australia
- Rest of Asia-Pacific
- Japan
- China
- India
- LAMEA
- Brazil
- Saudi Arabia
- South Africa
- Rest of LAMEA
Key Market Players
- 3d Biotek LLC
- Advanced Biomatrix, Inc.
- Avantor, Inc.
- Becton, Dickinson And Company
- Corning Incorporated
- Insphero AG
- Lonza Group LTD.
- Merck & Co., Inc.
- Synthecon, Incorporated
- Thermo Fisher Scientific Inc.
Table of Contents
Chapter 1: Introduction
Chapter 2: Executive Summary
Chapter 3: Market Overview
Chapter 4: 3D Cell Culture Market, by Product
Chapter 5: 3D Cell Culture Market, by Application
Chapter 6: 3D Cell Culture Market, by End-user
Chapter 7: 3D Cell Culture Market, by Region
Chapter 8: Company Profiles
List of Tables
List of Figures
Executive Summary
According to the report, “3D Cell Culture Market," the 3d cell culture market was valued at $1.6 billion in 2021, and is estimated to reach $8.3 billion by 2031, growing at a CAGR of 18.2% from 2022 to 2031.A 3D cell culture is defined as an assembly of biological cells in in-vitro environment in a particular pattern that resembles the in-vivo conditions present inside the human body. 3D cell cultures are mainly categorized into three types namely, standard cultures, organ-on-chip models, and tissue bioengineering. The use of 3D cell culture technology is recognized as an essential tool in drug discovery, toxicology testing, tissue engineering, and basic research. Cell culturing in 3D allows the expression of extracellular matrix (ECM) components and enhanced interactions with the culture environment.
These characteristics play an important role in replicating in-vivo processes such as cell adherence, differentiation and proliferation in in-vitro conditions. The implementation of these approaches for developing predictive in-vitro screening assays resembling physiological environment for preclinical drug development is facilitating the use of 3D cell cultures in research.
The global 3D cell culture market size has witnessed exponential growth in the past few years due to shift in preferences of the researchers toward the use of these cultures, especially in cancer research. The cells in these cultures grow three dimensionally with zones of oxygen & nutrient gradients and cellular heterogeneity that closely reflects in-vivo microenvironment. As a result, several cellular functional differences such as alterations in protein expressions and responsiveness to inhibitor molecules are observed when cells are grown in 3D cell cultures in comparison to 2D.
Thus, these cultures provide a competitive edge over the monolayer cultured cells notably in drug discovery and development. Therefore, these factors are expected to impel the growth of the market during the forecast period. Moreover, global rise in the demand for organ transplantation owing to prevalence in lifestyle and chronic diseases is predicted to supplement the market growth further. On the contrary, costs associated with implantation of 3D cell cultures in contrast to 2D and irregularity in outcomes due to lack of standardized protocols are anticipated to restrict the growth of the market.
However, the emergence of advanced and innovative 3D cell culture technologies in coming years is expected to fuel the market growth. Furthermore, the impact of COVID-19 pandemic is expected to remain moderate for pharmaceutical and biotechnological companies in the 3D cell culture industry. The prominent players in the market are facing a set-back, due to the lockdowns, which has led to a drop in the manufacturing and use of 3D cell culture among the researchers across universities & academic institutes. However, this deleterious impact is being compensated by a rapid development in stem cell therapy research and increase in R&D for developing regenerative medicines for treating COVID-19 patients.
The 3D cell culture market size is segmented on the basis of product, application, end user, and region. By product, the market is classified into scaffold-based platforms, scaffold-free platforms, gels, bioreactors, microchips, and services. The scaffold-based platforms segment dominated the 3D cell culture market share in 2021, and is estimated to register a CAGR of 18.8% from 2022-2031.
By application, the 3D cell culture market is divided into cancer research, stem cell research, drug discovery, and regenerative medicine. The cancer research segment dominated the global 3D cell culture market trends in 2021, and is estimated to register a CAGR of 17.3% from 2022 to 2031.
By end user, the market is categorized into biotechnology & pharmaceutical companies, contract research laboratories, and academic institutes. The academic institutes segment dominated the 3D cell culture market analysis in 2021, and is expected to grow with a significant growth rate of 18.45% from 2022 to 2031.
Region wise, the market has been analyzed across four regions namely, North America, Europe, Asia-Pacific, and LAMEA. The North America 3D cell culture market accounted for a major share of the global market registering an estimated CAGR of 16.3% during the forecast period. The growth trend in the North America market is characterized by the maturity of the market, in terms of penetration and availability of advanced 3D cell culture products.
Key Findings of the Study
- By product, microchips segment is expected to grow at the highest CAGR of 21.3% during the forecast period.
- By end user, the academic institutes segment accounted for nearly half of the share of the global 3D Cell Culture industry in 2020.
- Region-wise, Asia Pacific is expected to experience growth at the highest rate, registering a CAGR of 19.8% during the 3D cell culture market forecast period.
Companies Mentioned
- 3d Biotek LLC
- Advanced Biomatrix, Inc.
- Avantor, Inc.
- Becton, Dickinson And Company
- Corning Incorporated
- Insphero AG
- Lonza Group LTD.
- Merck & Co., Inc.
- Synthecon, Incorporated
- Thermo Fisher Scientific Inc.
Methodology
The analyst offers exhaustive research and analysis based on a wide variety of factual inputs, which largely include interviews with industry participants, reliable statistics, and regional intelligence. The in-house industry experts play an instrumental role in designing analytic tools and models, tailored to the requirements of a particular industry segment. The primary research efforts include reaching out participants through mail, tele-conversations, referrals, professional networks, and face-to-face interactions.
They are also in professional corporate relations with various companies that allow them greater flexibility for reaching out to industry participants and commentators for interviews and discussions.
They also refer to a broad array of industry sources for their secondary research, which typically include; however, not limited to:
- Company SEC filings, annual reports, company websites, broker & financial reports, and investor presentations for competitive scenario and shape of the industry
- Scientific and technical writings for product information and related preemptions
- Regional government and statistical databases for macro analysis
- Authentic news articles and other related releases for market evaluation
- Internal and external proprietary databases, key market indicators, and relevant press releases for market estimates and forecast
Furthermore, the accuracy of the data will be analyzed and validated by conducting additional primaries with various industry experts and KOLs. They also provide robust post-sales support to clients.
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