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Biological Safety. Principles and Practices. Edition No. 5. ASM Books

  • ID: 5226740
  • Book
  • February 2017
  • John Wiley and Sons Ltd

Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk - no matter how small - must be considered, assessed, and properly mitigated. If the science isn't safe, it isn't good. Now in its fifth edition, Biological safety: Principles and Practices remains the most comprehensive biosafety reference.

Led by editors Karen Byers and Dawn Wooley, a team of expert contributors have outlined the technical nuts and bolts of biosafety and biosecurity within these pages. This book presents the guiding principles of laboratory safety, including: the identification, assessment, and control of the broad variety of risks encountered in the lab; the production facility; and, the classroom.

Specifically, Biological Safety covers

  • protection and control elements - from biosafety level cabinets and personal protection systems to strategies and decontamination methods
  • administrative concerns in biorisk management, including regulations, guidelines, and compliance
  • various aspects of risk assessment covering bacterial pathogens, viral agents, mycotic agents, protozoa and helminths, gene transfer vectors, zooonotic agents, allergens, toxins, and molecular agents as well as decontamination, aerobiology, occupational medicine, and training

A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological safety is also a critical reference for laboratory managers, and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.

Note: Product cover images may vary from those shown


Contributors ix

Foreword - Caryl P. Griffin and James Welch xiii

Preface xv

Section I. Hazard identification

1. The Microbiota of Humans and Microbial Virulence Factors 3
Paul A. Granato

2. Indigenous Zoonotic Agents of Research Animals 19
Lon V. Kendall

3. Biological Safety Considerations for Plant Pathogens and Plant-Associated Microorganisms of Significance to Human Health 39
Anne K. Vidaver, Sue A. Tolin, and Patricia Lambrecht

4. Laboratory-Associated Infections 59
Karen Brandt Byers and A. Lynn Harding

Section II. Hazard assessment

5. Risk Assessment of Biological Hazards 95
Dawn P. Wooley and Diane O. Fleming

6. Protozoa and Helminths 105
Barbara L. Herwaldt

7. Mycotic Agents 147
Wiley A. Schell

8. Bacterial Pathogens 163
Travis R. McCarthy, Ami A. Patel, Paul E. Anderson, and Deborah M. Anderson

9. Viral Agents of Human Disease: Biosafety Concerns 187
Michelle Rozo, James Lawler, and Jason Paragas

10. Emerging Considerations in Virus-Based Gene Transfer Systems 221
J. Patrick Condreay, Thomas A. Kost, and Claudia A. Mickelson

11. Biological Toxins: Safety and Science 247
Joseph P. Kozlovac and Robert J. Hawley

12. Molecular Agents 269
Dawn P. Wooley

13. Biosafety for Microorganisms Transmitted by the Airborne Route 285
Michael A. Pentella

14. Cell Lines: Applications and Biosafety 299
Glyn N. Stacey and J. Ross Hawkins

15. Allergens of Animal and Biological Systems 327
Wanda Phipatanakul and Robert A. Wood

Section III. Hazard Control

16. Design of Biomedical Laboratory and Specialized Biocontainment Facilities 343
Jonathan T. Crane and Jonathan Y. Richmond

17. Primary Barriers and Equipment-Associated Hazards 367
Elizabeth Gilman Duane and Richard C. Fink

18. Primary Barriers: Biological Safety Cabinets, Fume Hoods, and Glove Boxes 375
David C. Eagleson, Kara F. Held, Lance Gaudette, Charles W. Quint, Jr., and David G. Stuart

19. Arthropod Vector Biocontainment 399
Dana L. Vanlandingham, Stephen Higgs, and Yan-Jang S. Huang

20. Aerosols in the Microbiology Laboratory 411
Clare Shieber, Simon Parks, and Allan Bennett

21. Personal Respiratory Protection 425
Nicole Vars McCullough

22. Standard Precautions for Handling Human Fluids, Tissues, and Cells 443
Debra L. Hunt

23. Decontamination in the Microbiology Laboratory 463
Matthew J. Arduino

24. Packing and Shipping Biological Materials 475
Ryan F. Relich and James W. Snyder

Section IV. Administrative Control

25. Developing a Biorisk Management Program to Support Biorisk Management Culture 495
LouAnn C. Burnett

26. Occupational Medicine in a Biomedical Research Setting 511
James M. Schmitt

27. Measuring Biosafety Program Effectiveness 519
Janet S. Peterson and Melissa A. Morland

28. A ""One-Safe"" Approach: Continuous Safety Training Initiatives 537
Sean G. Kaufman

29. Biosafety and Biosecurity: Regulatory Impact 551
Robert J. Hawley and Theresa D. Bell Toms

Section V. Special Environments

30. Biological Safety and Security in Teaching Laboratories 565
Christopher J. Woolverton and Abbey K. Woolverton

31. Biosafety in the Pharmaceutical Industry 585
Brian R. Petuch

32. Biosafety Considerations for Large-Scale Processes 597
Mary L. Cipriano, Marian Downing, and Brian R. Petuch

33. Veterinary Diagnostic Laboratories and Necropsy 619
Timothy Baszler and Tanya Graham

34. Special Considerations for Animal Agriculture Pathogen Biosafety 647
Robert A. Heckert, Joseph P. Kozlovac, and John T. Balog

35. Biosafety of Plant Research in Greenhouses and Other Specialized Containment Facilities 665
Dann Adair, Sue Tolin, Anne K. Vidaver, and Ruth Irwin

36. Biosafety Guidelines for Working with Small Mammals in a Field Environment 679
Darin S. Carroll, Danielle Tack, and Charles H. Calisher

37. Components of a Biosafety Program for a Clinical Laboratory 687
Michael A. Pentella

38. Safety Considerations in the Biosafety Level 4 Maximum-Containment Laboratory 695
David S. Bressler and Robert J. Hawley

Index 719

Note: Product cover images may vary from those shown
Karen B. Byers
Dawn P. Wooley
Note: Product cover images may vary from those shown