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Antibodies for Infectious Diseases. Edition No. 1. ASM Books

  • ID: 5227521
  • Book
  • May 2015
  • 457 Pages
  • John Wiley and Sons Ltd
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State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseases

The connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source.

Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book

  • presents general features pertaining to structure, function, isotype, and the role of complement in antibody function
  • examines the role of antibodies in antimicrobial immunity with specific targets
  • details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects

Antibodies for Infectious Diseases is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students.

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1 History and Practice: Antibodies in Infectious Diseases

General Features of Immunoglobulins

2 Functions of Antibodies

3 Antibody Structure

4 The Role of Complement in Antibody Therapy for Infectious Diseases

5 Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment

Antibody Discovery Approaches

6 Phage and Yeast Display

7 Efficient Methods To Isolate Human Monoclonal Antibodies from Memory B Cells and Plasma Cells

8 Use of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies

9 Humanized Mice for Studying Human Immune Responses and Generating Human Monoclonal Antibodies

10 Antibodies: Computer-Aided Prediction of Structure and Design of Function

Pathogen-Specific Antibodies

11 Antibodies Targeting the Envelope of HIV-1

12 Committing the Oldest Sins in the Newest Kind of Ways - Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head

13 Prevention of Respiratory Syncytial Virus Infection: From Vaccine to Antibody

14 Human Metapneumovirus

15 Dengue Antibody-Dependent Enhancement: Knowns and Unknowns

16 Immunotherapeutic Approaches To Prevent Cytomegalovirus-Mediated Disease

17 Rotavirus

18 Bacterial Toxins - Staphylococcal Enterotoxin B

Technical Advances

19 Antibody Engineering

20 High-Throughput DNA Sequencing Analysis of Antibody Repertoires

21 Antibody Informatics: IMGT, the International ImMunoGeneTics Information System Strains

22 Probing Antibody-Antigen Interactions

23 Radiolabeled Antibodies for Therapy of Infectious Diseases

Alternate Systems for Expression

24 Plant-Derived Monoclonal Antibodies for Prevention and Treatment of Infectious Disease

25 Vector-Mediated In Vivo Antibody Expression


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Diana Boraschi CNR Institute of Protein Biochemistry.

Rino Rappuoli IRIS, Siena, Italy.

James E. Crowe, Jr. Humabs BioMed SA.
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