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Remote C-H Bond Functionalizations. Methods and Strategies in Organic Synthesis. Edition No. 1

  • ID: 5229255
  • Book
  • February 2021
  • 448 Pages
  • John Wiley and Sons Ltd
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A guide to contemporary advancements in the field of distal C?H functionalization

Remote C?H Bond Functionalizations provides a comprehensive overview on the most recent developments in the field of distal C?H functionalization. The text explores how distal C?H functionalization can be applied in various pharmaceutical and agrochemical industries. With contributions from a noted panel of experts on the topic, the book offers a coherent and comprehensive discussion about different strategies.

The contributors cover a broad range of topics including C?H functionalization of palladium/norbornene catalysis, ruthenium-catalyzed remote functionalization, the non-directed distal C(sp2)?H, functionalization, transition metal catalyzed distal para-selective C?H functionalization, and much more. The book also includes information on effective strategies as well as the engineering of templates. Throughout the book, the authors lay the foundations for future research. This important book: - Contains the most recent research on one of the most important topics in organic synthesis - Provides a broad overview on contemporary advancements in the field of distal C?H functionalization - Includes deep insights into distal C?H functionalizations - Offers information on applications in various industries

Written for organic chemists, chemists working with organometallics, and industrial chemists, Remote C?H Bond Functionalizations presents a systematic compilation of the field.
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Transition Metal Catalyzed (Pd, Rh, Cu) Meta C-H Functionalization of Arenes by Directing Group Approach
Norbornene Mediated Distal C-H Functionalization of Haloarenes
Directing Group Assisted Meta C-H Functionalization by Catellani Reaction
Ruthenium Catalyzed Remote C-H Functionalization
Carboxylic Group as a Traceless Directing Group for Distal C(sp2)-H Functionalization
Harnessing Non-Covalent Interaction for Distal C(sp2)-H Functionalization by Ir and Pd
Non-Directed Distal C(sp2)-H Functionalization
Transition Metal Catalyzed Para C-H Functionalization of Arenes
Functionalization of Indoles and Related Heterocycles at Distal Positions (other than C2 and C3)
Mechanistic Perspective for Distal C(sp2)-H Activation
Directing Group Assisted Distal C(sp3)-H Functionalization of Acid, Amine, Ketone, Alcohol, and Thiol.
Radically Initiated Distal C(sp3)-H Functionalization
The Enzymatic Distal C(sp2)-H and C(sp3)-H Activation
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Debabrata Maiti
Srimanta Guin
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