+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

PRINTER FRIENDLY

Methodologies in Amine Synthesis. Challenges and Applications. Edition No. 1

  • ID: 5229411
  • Book
  • February 2021
  • 480 Pages
  • John Wiley and Sons Ltd
1 of 3

Provides a unique overview of efficient synthetic routes to one of the most important compound classes in organic and pharmaceutical chemistry!

Amines are among the most important compounds in organic chemistry due to their wide occurrence in natural products, drugs, crop protection compounds, and advanced materials. For example, the majority of drugs are amines or contain functional groups derived from amines. Powerful and efficient methods for the introduction of the amino group are therefore of great importance to synthetic chemists in academia and industry.

Methodologies in Amine Synthesis: Challenges and Applications presents powerful and state-of-the-art methods for the efficient preparation of amines. It summarizes recent advances in the electrophilic amination reaction, hydroamination, C?H amination as well as newly developed photocatalytic approaches. It further describes organocatalytic and enzymatic routes to the generation of amines under mild and environmentally friendly conditions. In addition, it highlights the relevance of the amino function in bioactive molecules, drugs, and in the engineering of smart materials. Finally, the application of palladium-catalyzed aromatic amination in industrial context is critically discussed.

  • Only up-to-date and comprehensive book on the preparation of amines ? one of the most frequently occurring compound classes found in natural products, bioactive molecules, and advanced materials.
  • Presents efficient and useful synthetic methods, highlights opportunities / challenges as well as applications in pharmaceutical chemistry and materials science.
  • Chapters are compiled by well-known experts in the field. One of them edited the previous books Modern Amination Methods (2001) and Amino Group Chemistry (2007).

The book Methodologies in Amine Synthesis: Challenges and Applications is a musthave for chemists in academia and industry working in the field of organic synthesis and catalysis, natural product chemistry, drug synthesis and pharmaceutical chemistry, as well as materials science.

Note: Product cover images may vary from those shown
2 of 3

Preface xi

1 Substitution-type Electrophilic Amination Using Hydroxylamine-Derived Reagents 1
Zhe Zhou and László Kürti

1.1 Introduction 1

1.2 Cu-Catalyzed Reactions 2

1.3 Electrophilic Amination Reactions Catalyzed by Other Transition Metals 15

1.4 Electrophilic Amination with Hydroxylamine-derived Metallanitrenes 18

1.5 Transition-Metal-Free Electrophilic Amination Reactions 22

1.6 Conclusion 28

2 Remote Functionalizations Using Nitrogen Radicals in H-Atom Transfer (HAT) Reactions 31
Ji Hye Kim, Elizabeth M. Dauncey and Daniele Leonori

2.1 Introduction 31

2.2 Intramolecular 1,5-H-Atom Transfer (1,5-HAT) 31

2.3 Photoinduced Strategies 34

2.4 Thermal Strategies 46

2.5 Summary and Conclusions 50

3 Radical-Based C-N Bond Formation in Photo/Electrochemistry 53
Binbin Huang, Yating Zhao and Wujiong Xia

3.1 Introduction 53

3.2 C-N Bond Formation via N-radical Species Addition 54

3.3 Amination via N-atom Nucleophilic Addition 77

3.4 Amination via Radical Cross-coupling 90

3.5 Summary and Conclusions 98

4 Propargylamines: Recent Advances in Asymmetric Synthesis and Use as Chemical Tools in Organic Chemistry 103
Fei Zhao, Seong-Heun Kim and Daniele Castagnolo

4.1 Introduction 103

4.2 Metal-Catalyzed Asymmetric Synthesis of Propargylamines 104

4.3 Enzymatic Synthesis of Propargylamines 126

4.4 Photoredox Synthesis of Propargylamines 130

4.5 Organocatalyzed Asymmetric Synthesis of Propargylamines 134

4.6 Propargylamines as Building Blocks in the Synthesis of Heterocycles 137

4.7 Conclusions 150

5 Transition-Metal-Catalyzed Chiral Amines Synthesis 155
Anton Cunillera, Carmen Claver, Cyril Godard, Martine Urrutigoïty and Philippe Kalck

5.1 Introduction 155

5.2 Asymmetric Reductive Amination 156

5.3 Asymmetric Hydroamination 162

5.4 Asymmetric Hydroaminoalkylation 168

5.5 Asymmetric Hydroaminomethylation 171

5.6 Coupling on a Chiral Metal Center 176

5.7 Conclusion 177

6 Industrial Relevance of Asymmetric Organocatalysis in the Preparation of Chiral Amine Derivatives 187
Luca Bernardi, Armando Carlone and Francesco Fini

6.1 Introduction 187

6.2 Organocatalysis in Manufacture: Representative Examples 189

6.3 Case Studies 200

6.4 Summary and Conclusions 230

7 Biocatalytic Synthesis of Chiral Amines Using Oxidoreductases 243
Sebastian C. Cosgrove, Jeremy I. Ramsden, Juan Mangas-Sanchez and Nicholas J. Turner

7.1 Introduction 243

7.2 Amine Oxidases 243

7.3 Amine Dehydrogenases 252

7.4 Imine Reductases 262

7.5 Engineered Cytochrome P450s 270

7.6 Conclusions and Perspectives 274

8 Engineering Functional Nanomaterials Through the Amino Group 285
Giacomo Filippini, Paolo Pengo, Susanna Bosi, Giulio Ragazzon, Lucia Pasquato and Maurizio Prato

8.1 Abbreviations 285

8.1 Introduction 287

8.2 Quantification of Nanomaterial-Bound Amino Groups 288

8.3 Exploiting Amino Compounds for the Functionalization of Carbon-Based Nanomaterials 290

8.4 Amines in the Synthesis and Functionalization of Carbon Dots 309

8.5 Amines for the Engineering of Hybrid Organic-Inorganic Nanomaterials 316

9 Recent Advances in the Synthesis of Nitrogen Compounds from Biomass Derivatives 341
Ana C. Fernandes

9.1 Introduction 341

9.2 Synthesis of Nitrogen Compounds from Chitin and Its Derivatives 341

9.3 Synthesis of Amines and Formamides from Alpha-Amino Acids 345

9.4 Synthesis of Nitrogen Compounds from Cellulosic Biomass Derivatives 348

9.5 Synthesis of Nitrogen Compounds from Lignin Derivatives 366

9.6 Synthesis of Nitrogen Compounds from Triglycerides and Fatty Alcohols 370

9.7 Conclusion 373

10 Recent Advances in the Synthesis of Arylamines in the Light of Application in Pharmaceutical and Chemical Industry 377
Dino Berthold, Alexander M. Haydl, Joyce C. Leung, Ulrich Scholz, Qing Xiao and Zhibin Zhu

10.1 Modern Approaches to Transition-Metal-Catalyzed C-N Coupling in Industry 377

10.2 New Methodologies in the Synthesis of Arylamines on the Brink of Industrial Application 388

10.3 Advances to Arylamine Formation Using Intensified and More Sustainable Process Technologies 424

10.4 Miscellaneous Aspects of Aromatic Amination Reactions in theWorld of Active Pharmaceutical Ingredients 431

References 435

Index 445

Note: Product cover images may vary from those shown
3 of 3
Alfredo Ricci Universita di Bologna, Italy.

Luca Bernardi
Note: Product cover images may vary from those shown
Adroll
adroll