The global single cell technology (SCT) market has emerged since 2014. There are over 43 companies with various 49 SCT products commercialized worldwide, and over 15 pre-commerce-stage startups are lined up and keep increasing. The market size is over $800 M in 2019, at a CAGR of ~24%.
The market is expected to grow significantly by the growing awareness of the single cell projects among biology communities, the growth of precision medicine and diagnostic industry, the antibody therapeutic drug development, the entry of new players, etc.
However, the high cost of the equipment, the requirement of in-person demo, various remaining technical challenges & defaults of the products that rushed into the market too early, and lack of interdisciplinary expertise on the customer sides could limit the market growth rates. Acquisitions and partnerships are actively seen as for most of the competitive technology industry.
The majority (~60%) of the market players are small-sized startup companies with under 100 employees, however, the market share is highly concentrated on four major companies (BD, 10x genomics, Fluidigm, and Berkeley light), yet this market share can change as the market is expanding and more new players are entering, more differentiation among players is expected.
Primarily, the SCT market has a complex market structure characterized by its wide range of technology mixtures and various types of users across various life science research fields. The general functionalities of the SCT are: single cell (SC) isolation, SC-sequencing, SC-protein analysis, or SC-focused manipulation. Among those, the first two category products (SC-isolation and SC-sequencing) account for ~72% of the market.
SCT can be applied in most of the life science application as it is defined by any biological science experimentation that handles and generate single cell resolution data. Stem cell research and cancer research are the fields of studies that have adapted SCT the most, and immunology and neurobiology also have a growing need in SCT. The market is categorized by the core technologies (11 categories) and by the applications (5 categories).
The core technology categories include conventional cell picking, limited dilution, FACS, and laser capture microdissection (LCM) technologies, but also novel technologies for automatic single cell picking, automatic single cell dispensing, microwell-based single cell isolation/analysis, microfluidic chip based-single cell analysis, droplet microfluidics-based, novel cytometry, and cell manipulation. The five market application categories include SC-isolation, SC-DNA/RNA sequencing, cell line development, protein or functional analysis, and drug discovery & diagnostics.
Important Features of the Report
People tend to be confused with a clear definition of what single cell technology is. Here, SCT is defined as all biology research instruments that generate single cell level data set, which then exclude general sequencing reagents, cell population sorting, or high-resolution processing solutions, and include single cell phenotypic research tools, like patch clamp.
This report introduces you all the single cell resolution commercial technology available in the world.
Biotechnology development involves the understanding of the three different fields: the market’s financial aspect, biological use cases (application) aspect, and technological aspect. Therefore, this report contains not only the financial side of the market information but also biological and technological information to complete the whole picture.
- Part one looks at the market from the global perspective asking questions like who are the key players, what are the revenues generated by them, what is the growth potentials and what strategic moves were made by current players.
- Part two looks at the market from the customers' perspective: why single cell biology is important, which fields are demanding single cell technologies, and what are the customers’ needs.
- Part three looks at the market by the different SCT technologies and target applications, and provides information on comprehensive single cell resolution enabling technologies, including pre-commercial stage startup companies entering the market.
The report aims to help biotechnology industry leaders who are already in the single cell technology field or intend to develop such technology as well as investors who are interested in learning more on the whole market technology landscape.
Part One: the Market and Strategy Perspectives
Chapter 1 Market Structure and Market Size
1.1 Market Structure
- The Complexity of the SCT Market
- Market Players
1.2 Market Size
- Market Size by Revenue
- Market Share
- Market Forecast
1.3 Market's Dynamic Growth & Restraint Factors
- External Influencers
- The Time is Now: a Paradigm Shift in Biology Research
Chapter 2 Projecting Strategic Plans
2.1 Strategic Moves by Current SCT Companies
- R & D Expenditures
- Recent Partnerships and Acquisitions
- Marketing Channels
2.2 Market Innovating Strategy
- The Core Concept of Strategy and a Concept of Trade-Off
Part Two: Biology and Its Evolution- Market from the Customers Perspective
Chapter 3 Single Cell Biology by -Omics and Field of Study
3.1 Single Cell Biology: Physics and Engineering Meet Biology
- Why Single Cell
- Remained Challenges in SC Studies
3.2 Single Cell Biology by -Omics Fields
- What is Inside of a Cell?
- Intro to Genomics, Epi-Genomics, and Transcriptomics (=Sequencing Omics)
- Introduction to Proteomics
- Other Omics That Complete Phenomics, Integrated Omics
3.3 Single Cell Biology by Field of Studies
- SCT Can be Applied in Almost Every Life Science Domain
- Popular Fields of Study
Chapter 4 Understanding the Customer and Their Workflow
4.1 Understand the Customer's Workflow
- Single-Cell Analysis Workflow
4.2 Understand the Customer Experience Cycle
- The Cost vs the Value Before Making a Purchase Decision
Part Three: Market from the Technology Providers Perspective
Chapter 5 Market Segments by Technology
5.2 Manual Picking
5.3 Limited Dilution
5.4 FACS: Fluorescence Activated Cell Sorter
- Limitation of FACS
- Market Trends for Facs and Emergence of Microfluidic Chip-Based Cell Sorter
5.5 Laser Capture Microdissection (LCM)
5.6 Automatic Single Cell Pickers
5.7 Single Cell Dispensing
5.8 Microwell Based Single Cell Isolation
5.9 Microfluidics Chip-Based Single Cell Analysis
5.10 Droplet Microfluidics
5.11 New Type of Cytometry and Spectroscopy
5.12 Fluidics and Cell Manipulation
Chapter 6 Market Segments by Applications
6.2 SC-Dna and Rna Sequencing
6.3 Cell Line Development
6.4 Protein or Functional Analysis
6.5 Drug Discovery and Diagnostics
Chapter 7 Emerging Early Stage SCT Startup Companies
7.1 Emerging Early Stage SCT Startup Companies
About the Author
List of Figures
Figure 1.1 The Complexity of the SCT Market is Caused by Various Purposes and Various Customers.
Figure 1.2 A Surge of SCT Products Released Since 2014.
Figure 1.3 Current Single Cell Biotechnology Market Space by Their Main Functionalities and the Number of Products in Each Category.
Figure 1.4 Life Cycle of a Novel Biotech Product Moving from Monopoly to Monopolistic Competition.
Figure 1.5 The Porter's Five Forces.
Figure 1.6 The Size of the SCT Companies by Number of Employees
Figure 1.7 The Size of the SCT Companies by Their Revenues (Unit: Millions USD)
Figure 1.8 The Location of the SCT Companies on the World Map.
Figure 1.9 Revenue and Net Income Trajectories of the Fluidigm, 10X Genomics, Berkeley Light.
Figure 1.10 the SCT Market Size Grouped by Company Sizes and by the 4 Companies’ Market Share.
Figure 1.11 Market Share of the Top 4 Players
Figure 1.12 Questions Around Market Size by Volume
Figure 1.13 Global Enterprise Expenditure on R&D in 2017, Source: Oecd Stat.
Figure 1.14 Propagation of Single Cell Biology in the Entire Life Science Biology Space.
Figure 1.15 Single Cell Technology Market Revenue (Us$ Mn) and Market Growth Y-O-Y (%) 2017~2025
Figure 1.16 Strategic Planning Requires Both Internal and External Perspectives. the Four Layers of External Influences.
Figure 1.17 Long Term Growth Factors and Short-Term Restraints
Figure 1.18 Life Cycle of Technology Product in the Timeline
Figure 2.1 Various Competitive Advantages That a Company Can Choose to Focus on to Grow.
Figure 2.2 The Flow of the Value Chain Until It Reaches the Customers.
Figure 2.3 Marketing Channels to Communicate with the Customers and the Public.
Figure 2.4 A Poster by Blue Ocean Strategy
Figure 2.5 Core Concept of Strategy.
Figure 2.6 The Eliminate-Reduce-Raise-Create Grid
Figure 2.7 Reasons of Non-Customers
Figure 3.1 The Comparison of Bulk Assay and Single Cell Assay.
Figure 3.2 The Intrinsic Challenges Surrounding High Throughput Single Cell Studies.
Figure 3.3 The Purpose and Definition of Single Cell Biology
Figure 3.4 Towards Understanding Cell Types and Cell State
Figure 3.5 The History of Technology Breakthroughs That Are Relevant to Sc Biology.
Figure 3.6 What is Inside of a Cell?
Figure 3.7 What is -Omics in Biology?
Figure 3.8 The Layer of Eight Different Omics in Biology.
Figure 3.9 Evolution of Dna Sequencing Technology.
Figure 3.10 Workflows of Mass Spectrometry
Figure 3.11 Multi-Omics That Complete Phenomics.
Figure 3.12. Things to Study When Looking at a Cell.
Figure 3.13 the Four Popular Fields of Study That Actively Use SCT + the Rest of Biology.
Figure 3.14 Mesh Search Query of “Single-Cell Analysis” vs “Cytological Techniques”.
Figure 3.15 the Number of Papers Count Comparison of the Four Major Fields for Mesh Search Query
Figure 4.1 The Overview of the Workflow of Conventional Bulk Cell Experiments vs Single Cell Experiments
Figure 4.2 In Various Sc-Omics Workflow, the First Step is Single Cell Isolation.
Figure 4.3 The Process of Deciding Sc Research Projects
Figure 4.4 The Criteria That Researchers Look for When Purchasing a Biotech Equipment
Figure 4.5 A Typical Sale Cycle for Biotech Instruments.
Figure 5.1 the Eleven Single Cell Biotechnologies Classified in this Report.
Figure 5.2 Technology Add-On Towards Current FACS.
Figure 5.3 Strategic Canvas of Facs vs Microfluidics Single Cell Sorter.
Figure 5.4 The Three Technology Units Enabling Automatic Single Cell Picking Solution.
Figure 5.5 The Two Variables to Perfect Single Cell Dispensing Technology.
Figure 5.6 Micro-Fabrication Microwells That Are Applied for Various Single Cell Bioassays.
Figure 5.7 The Technology Add-On to Reach Droplet Single Cell Sequencing Technology.
Figure 5.8 The SCT Market Landscape by 43 Company Counts (With Company Logos)
Figure 5.9 The SCT Market Space by 43 Company Counts
Figure 5.10 The SCT Market Space by 49 Product Counts
Figure 6.1 Two Factors in Deciding the Application Solution.
Figure 6.2 the Five Categories of the SCT Applications
Figure 6.3 Pricing Map (For Reagent Cost) of the Four Technologies Against the Level of Throughput.
Figure 6.4 Mammalian Cell Line Development Workflow.
Figure 6.5 Important Criteria of CLD Applications.
Figure 6.6 Affinity Based Fluorescence Assay
Figure 6.7 Pioneer, Migrator, Settler Map of Single Cell Protein Analysis Products
Figure 7.1 Map of Technology and Market Landscape of the 15 Emerging SCT Startups.
List of Tables
Table 1.1 Four Market Structures in the Order of Competitiveness from High to Low
Table 1.2 Revenues of the 8-Medium Size (By Employee Number) Market Players
Table 1.3 Estimated Revenues of the 25 Small Size Startup Companies
Table 1.4 Revenues of the 10 Big Biotech Companies with SCT Products (Million Usd)
Table 1.5 SCT Market Shares by Functional Categories
Table 1.6 Global Research Budgets for Life Science Academic Institutes (The Year 2018 or 2019)
Table 1.7 Other Market Reports Analysis on SCT Markets
Table 1.8 A List of Market Growth Drivers and Restraints.
Table 2.1 R & D Expenses of the Major SCT Biotech Companies. Units: Million Usd.
Table 2.2 Recent Partnerships of the SCT Companies
Table 2.3 Recent 10 Acquisitions by SCT Companies
Table 3.1 The Five Cellular Elements Composition Per (Human) Cell.
Table 3.2 Types of Sequencing Omics and Its Use Cases in Single Cell Approaches
Table 3.3 List of Methodologies Used in Proteomics with Single Cell Resolution
Table 3.4 Erc Life Science Domain Panel Structure
Table 4.1 The Research Articles Comparing Rna Sequencing Single Cell Biotechnologies.
Table 4.2 SCT Market Segmentation and the Customers' Point of View
Table 5.1 List of Limited Dilution Protocols
Table 5.2 List of 2 Facs Instruments to Sort Single Cells with the Price and Install Base.
Table 5.3 List of 4 Laser Capture Microdissection (Lcm) Instruments with the Price
Table 5.4 List of 5 Automatic Single Cell Picking Instruments with the Price and Install Base
Table 5.5 List of 9 Single Cell Dispensing Products with Price and Install Base
Table 5.6 The Single Cell Dispensing Technology Comparison Chart
Table 5.7 List of 8 Microwell Based Sc- Isolation/Analysis Instruments with the Price and Install Base
Table 5.8 List of 4 Microfluidics Chip Based Single Cell Analysis Instruments with Price and Install Base
Table 5.9 List of 6 Droplet Microfluidics-Based Instruments with Price and Install Base.
Table 5.10 List of 5 Novel Cytometry with the Price and Install Base
Table 5.11 List of the 5 Fluidics and Cell Manipulation Products with Price and Install Base
Table 6.1 List of the Current Single Cell Applications and the Number of Products in Each Segment.
Table 6.2 List of the 8+22 SCT Instrument Products Targeting Sc-Sequencing Application Market
Table 6.3 List of the 21 Single Cell Isolation/Dispensing Technology Products
Table 6.4 The Reagent Products for the Sc-Sequencing Application
Table 6.5 Comparisons of Four Sc-Rna-Seq Technologies
Table 6.6 List of the Companies Positioned in Cell Line Development (Cld) Market.
Table 6.7 List of the 14 SCT Instrument Products That Can be Used for Protein Analysis.
Table 6.8 Medical Application Targeting Products
Table 7.1 List of 15 the Early Stage SCT Startup Companies
- 10x genomics
- Becton Dickinson (BD)
- Berkeley lights
- Carl Zeiss
- Dolomite bio
- Leica Microsystems
- Menarini Silicon Biosystems
- Perkin Elmer
- Sony biotechnology
- TaKaRa Bio
+ a complete list of over 40 startup companies in single cell technology market